Conserved Protein Domain Family
YIF1

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pfam03878: YIF1 
YIF1
YIF1 (Yip1 interacting factor) is an integral membrane protein that is required for membrane fusion of ER derived vesicles. It also plays a role in the biogenesis of ER derived COPII transport vesicles.
Statistics
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PSSM-Id: 397797
Aligned: 106 rows
Threshold Bit Score: 173.509
Threshold Setting Gi: 307107856
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EHY57539      73 ND----P-AAQMGF-------QVGQTAMKA--GQEYMEQ--NLNRYIS--VSALKHYFNVSNSYVVRKLLLVLFPWRH-- 132 Exophiala derma...
XP_656389     29 NNiatnP-LASAGL-------SVAQNYLNQ--GDQLLKS--QLGGIFS--FDAWRYYFNVNTSFVLKKILMIIMPYPFl- 93  Entamoeba histo...
CDS41232      89 VN----QfAQNVAM-------QYGSEAIGQ--GRQLVQE--KVGKYFS--LSKLKHYFAVDNAYVAGKLGILLFPFFH-- 149 Echinococcus mu...
XP_001942801 131 SN----PlLAGVTV-------RYGQKILGQ-----VVDE--NVGKYTSgiSSEIKRYFAVDTRYVISKLGLLLFPFVH-- 190 pea aphid
Q20913        96 SD----P-MLNAAK-------QFGGQFAEQ--QKE------KLTKYLG--TFNLKYYFAVDNAYVGKKLGILFFPFFH-- 151 Caenorhabditis ...
XP_015787835  40 NQ----QlGNHMAQifqdqvsQYSDNLVSK--SKTWVGN--N-----------LKYYFAVDTGYVLKKILLIFFPFTH-- 98  two-spotted spi...
Q54XV4       133 SQisdnP-LTQAGLty---glNYGQTLFSG--GKQYVDS--NFGKYFS--FSTLKSYFNVNNSYVFNKIKLLIFPYTQ-- 200 Dictyostelium d...
EFA81589      87 SNfssnP-LAQASLsy---giNYGQTLFNG--GKQYVDS--NLGKYIS--FSSLKGYFNVNTSYVFNKIKLILFPFRQ-- 154 Heterostelium a...
XP_004361058  90 SSissnP-LAQVGF-------SYGQSLFND--GKQYVDS--NIGKYFS--FSSLKSYFNVNTSYVFNKIKLIIFPFPQ-- 153 Cavenderia fasc...
EFC49411      92 QN----P-TADFMI-------NMGVNQLYGsvGEKTNEVtsRYWQWFDg----LKCYFNVTNSYVSRKLLLVLFPFKKfd 155 Naegleria gruberi
EHY57539     133 KPWTRQQARMTTsSTaadgtmsqqtysfNYLPPRDDLNSPDMYIPIMALITYILLSTVLAGIRGSFHPELLGSITSTAIA 212 Exophiala derma...
XP_656389     94 GTWERKYVIGEDqSK-------------LYNVPQEDIYAPDLYIPLMGFISYVLAIGFYYGSKGTFTPETLSMTTTLCLI 160 Entamoeba histo...
CDS41232     150 TRWDLQYDAMGV------------------VSPRRDINSPDLYIPAMAFITYVVAAGVSLGVEGRFAPDLLGILSSQSFF 211 Echinococcus mu...
XP_001942801 191 TDWSIMLESTEQsDDr-----------rR-ARPKTDVNAPDLYIPTVAFVTYLLFLGLILGKHGQFSPELLSVQASRVLA 258 pea aphid
Q20913       152 KDWSLKFAGSADp-----------------APAREDVNAPDLYIPLMSFLTYILVSGFVLGTQGRFSPEILGILTSNALI 214 Caenorhabditis ...
XP_015787835  99 KDWSLKYRNDEQ------------------IAPRDDLNAPDLYIPWMAFVTYILVAGYLLGVNDRFSPEQLGIQASSALA 160 two-spotted spi...
Q54XV4       201 KTWKRRIGRTSDvDS--------------YLPPRDDINAPDLYIPLMAFITYFLLYGFQMGMEKKFSPDYLGACITKGIV 266 Dictyostelium d...
EFA81589     155 KLWKRRILKQGDnDH--------------YLPPRDDINAPDLYIPMMAFVTYFLLFGFQMGMKNSFSPDKLGASISKGII 220 Heterostelium a...
XP_004361058 154 KTWKRRIYRVGDvDS--------------YLPPRDDINAPDLYIPLMAFVTYYLLYGFQLGMGREFSPDKLGTAISKGIV 219 Cavenderia fasc...
EFC49411     156 TSYEYNNNNQNQtQE-------------------RHLSDPDLYIPLMGYITYVLLVCFIMGAHKEFKPELLYSIGMKGFI 216 Naegleria gruberi
EHY57539     213 VVIFEIIVLKLAMYML-SISnD-SQLLDLVAYSGYKFVGVIVTLFLSEVltggrGTNNwVGWTLFLYTWYANAFFLLRSL 290 Exophiala derma...
XP_656389    161 LISLEVMILKFLEYMLfNYS-SdFRI--YLSYVSYVFVPVLMCTFVGSL-----QIPY-LTYIALLFFGTSYAFFLYKTF 231 Entamoeba histo...
CDS41232     212 WLILEVCMLTLALYLL-NIQ-SsLGYLDLLAYCGYKFVHMITVVLVALV-----LSAP-GYYFALVWTGLAFAFFQIRSL 283 Echinococcus mu...
XP_001942801 259 WEVIVVLVEIMALYVT-NIQ-SsLRAFDLTAYSGYKYFGIISCIPIGLL-----FGET-AFYLALLYIGIAFMYFLLFSM 330 pea aphid
Q20913       215 WVILENIVIFISKYIL-NIS-QsLSVWHSLAYSTYKFAHMIVCLLLFMV-----GDKT-FYYGALAYSSLALVIFLLRSV 286 Caenorhabditis ...
XP_015787835 161 WLIFEVLATMIILYSF-NLM-SaFGFFHVLSLSGYKFVPMIAALLIALP-----FSSM-GYYISLAYGSLALCYFLIRNI 232 two-spotted spi...
Q54XV4       267 FWAIELLIFKCGFFFS-NSNs--IPFYDMISYSGYKYVLMVIFQIATIL-----LGSY-VSYIIKCVLSVSIAFFMLKTL 337 Dictyostelium d...
EFA81589     221 FWLLEIGFFKLGFFFT-NSYs--IPMYDMIAYSGYKYVLLVLTMVATML-----AGGA-VSLFVRLYTIACIGWFMICTL 291 Heterostelium a...
XP_004361058 220 GWLIEIGIFRLGSFFS-NSYs--IPIYDMIAYSGYKYVLMVITIISSIL-----TGGY-ISFFVKIYLVACLGVFILKTL 290 Cavenderia fasc...
EFC49411     217 TSLLEIAIVKFGFYAL-GVQ-SsLGVLDVAAFSGYKYIGIIITLVLSLL-----FGNY-AYYPSLLILGIMMVTFMIKSL 288 Naegleria gruberi
EHY57539     291 KYVLLPDSSSDptamrggsSYTvaraqKNRRTYFLALYAfLIQMLFMWILS 341 Exophiala dermatitidis NIH/UT8656
XP_656389    232 FGSLASIQT------------------EENKKRIYSICVgVFQIILIFFMM 264 Entamoeba histolytica HM-1:IMSS
CDS41232     284 KLQVLPQADRQa-------SLS------PRRGVYFLVCAaLFQPFIIWWLT 321 Echinococcus multilocularis
XP_001942801 331 RWQLNSIATVAnvgqpvvmVEY-----KRKRTLYFLILAvAIQPITAWYLI 376 pea aphid
Q20913       287 SHFMFDSSGSYg-------SEE-----GRKRKLILVAFVvITQPLIMWWLT 325 Caenorhabditis elegans
XP_015787835 233 HMAIETSPAT----------QG-----GGRQSTIKVIFFcLVQPLLMYHLT 268 two-spotted spider mite
Q54XV4       338 RLVFSSVSGAHdhis-pdyHES-----GKIKNYFVFGFS-VAQALLCFLV- 380 Dictyostelium discoideum AX4
EFA81589     292 RVVLLNDNNMHsdm---hhFEG-----TTKRKYFVFAVA-ILQVVLILLYS 333 Heterostelium album PN500
XP_004361058 291 RVVMVSDNSANshhdmhqqHEG-----SAMRNYFVFGVA-MLQCVILFFFN 335 Cavenderia fasciculata
EFC49411     289 RRSSVHSSDNSmrl---rlDTN-----TAKRNYFIFIVA-ILQIPLFFFLT 330 Naegleria gruberi
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