3H0G,1GO3,4QJF,3HKZ,6HLR,3AYH


Conserved Protein Domain Family
SHS2_Rpb7-N

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pfam03876: SHS2_Rpb7-N 
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SHS2 domain found in N-terminus of Rpb7p/Rpc25p/MJ0397
Rpb7 bind to Rpb4 to form a heterodimer. This complex is thought to interact with the nascent RNA strand during RNA polymerase II elongation. This family includes the homologs from RNA polymerase I and III. In RNA polymerase I, Rpa43 is at least one of the subunits contacted by the transcription factor TIF-IA. The N-terminus of Rpb7p/Rpc25p/MJ0397 has a SHS2 domain that is involved in protein-protein interaction.
Statistics
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PSSM-Id: 397796
Aligned: 122 rows
Threshold Bit Score: 30.5574
Threshold Setting Gi: 159113447
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3H0G_G         9 SLTISLHPSYFGPRMQDYLK---AKLLADVEGTCsgqYGYIICVLDSntIDIDK-GRV--V-PG-QG 67  Schizosaccharomyces pombe 972h-
XP_001613017  68 SCVAQLQPRYLNNVKDGLSVy-lSNFMLKANHDV---EGFTICFNGI--KLKEKePRV--I-NGdPS 125 malaria parasite P. vivax
Q8I662        68 SCVAQLQPKYLNKIDDGISVy-lSNFMLKANHDV---EGFCLCFNKI--KLKEKeSRV--MnND-PS 125 Plasmodium falciparum 3D7
Q5CSR5        84 KGTVQLLPNSIGNIEDSIKKy-lCCFLFHYIAEF---QGVWICFHKI--STVNTyGYVpdC-EP-NG 142 Cryptosporidium parvum
XP_001609052  79 LGVVQIHPSFLGNPLKGVYAy-lSNFLMQYNEDI---GGIWLTCGKI--TQLDQyGYV--TdGDcFG 137 Babesia bovis T2Bo
Q4N4D0        79 TGVVQIHPSYLGNVNSGIYAy-lSNFLMHYNDDF---SGVWISCGDI--VPLDSlGYL--TtGDyQG 137 Theileria parva
Q7PV20        32 NEILSLRPRDCEHIVKGVKRc-vTDKIGRYHAKL---NGIVLGYAKI--RVDNAlSAL--R-LD-SP 88  Anopheles gambiae str. PEST
Q16XZ3        34 TNLVSVLPKYLGDICEGVKAc-lTQKIGKYDRTV---DGIILAFKNT--KILSPlSAI--R-PN-SV 90  yellow fever mosquito
Q29JY4        33 DMHLSMGPYGMASFKHALHElliRTKVGIYDANL---SAIVLGIKKI--KVLGQtAAL--R-AD-DP 90  Drosophila pseudoobscura
XP_001303523  10 KVTVDIPVWRMGGLKDATKLillNKLL-TYDDTL---EGVILGIKNT--NPESPySKF--Y-AD-TP 66  Trichomonas vaginalis G3
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