3H0G,6HLR,3AYH,1GO3,4QJF,3HKZ


Conserved Protein Domain Family
SHS2_Rpb7-N
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pfam03876: SHS2_Rpb7-N 
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SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
Rpb7 bind to Rpb4 to form a heterodimer. This complex is thought to interact with the nascent RNA strand during RNA polymerase II elongation. This family includes the homologs from RNA polymerase I and III. In RNA polymerase I, Rpa43 is at least one of the subunits contacted by the transcription factor TIF-IA. The N terminus of Rpb7p/Rpc25p/MJ0397 has a SHS2 domain that is involved in protein-protein interaction.
Links
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Statistics
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PSSM-Id: 427560
Aligned: 120 rows
Threshold Bit Score: 31.3386
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3H0G_G         9 SLTISLHPSYFGPRMQDYLK---AKLLADVEGTCsgqYGYIICVLDsntIDIDK-GRV--V-PG-QG 67  Schizosaccharomyces pombe 972h-
XP_001613017  68 SCVAQLQPRYLNNVKDGLSVy-lSNFMLKANHDV---EGFTICFNGi--KLKEKePRV--I-NGdPS 125
Q8I662        68 SCVAQLQPKYLNKIDDGISVy-lSNFMLKANHDV---EGFCLCFNKi--KLKEKeSRV--MnND-PS 125 Plasmodium falciparum 3D7
Q5CSR5        84 KGTVQLLPNSIGNIEDSIKKy-lCCFLFHYIAEF---QGVWICFHKi--STVNTyGYVpdC-EP-NG 142 Cryptosporidium parvum
XP_001609052  79 LGVVQIHPSFLGNPLKGVYAy-lSNFLMQYNEDI---GGIWLTCGKi--TQLDQyGYV--TdGDcFG 137
Q4N4D0        79 TGVVQIHPSYLGNVNSGIYAy-lSNFLMHYNDDF---SGVWISCGDi--VPLDSlGYL--TtGDyQG 137 Theileria parva
XP_001303523  10 KVTVDIPVWRMGGLKDATKLillNKLL-TYDDTL---EGVILGIKNt--NPESPySKF--Y-AD-TP 66 
Q22DC8        19 EELIPLYPCDLRNLKNSLKNf-vQKKLFKWDQKH---QGIVLQCKNi--KKSSEkASI--H-DE-SP 75  Tetrahymena thermophila SB210
Q7PV20        32 NEILSLRPRDCEHIVKGVKRc-vTDKIGRYHAKL---NGIVLGYAKi--RVDNAlSAL--R-LD-SP 88  Anopheles gambiae str. PEST
Q29JY4        33 DMHLSMGPYGMASFKHALHElliRTKVGIYDANL---SAIVLGIKKi--KVLGQtAAL--R-AD-DP 90  Drosophila pseudoobscura
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