4M5D


Conserved Protein Domain Family
Nrap

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pfam03813: Nrap 
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Nrap protein domain 1
Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.
Statistics
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PSSM-Id: 397747
Aligned: 136 rows
Threshold Bit Score: 79.1476
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4M5D_A               203 IDTLLTMPKELFEKKDFLNFRCLHKRSVYLAYLTHHLLILLKKDkld--sflQLEYSYFDNDPLLPI--LRISCSkptgd 278  Saccha...
XP_004232410          99 VDLFLHLPKECFYEKDYLNYRYHAKRFLYLCKIKEQLTKSPLIK--------AVRWSSFQNEARKPI--LLVYPA----- 163  tomato
XP_003516574          99 VDLIIRLPKECFHEKDYLNYRYYAKRCLYLCLMKNYLEKSPSID--------RVEWSTLQNEARKPL--LVVYPA----- 163  soybean
2_pfamImport           1 VDLAVEMPQDCFLPKDFANYRYTDKRNLYVGVLAAELQAHGdl-------fqDVTLQAWHGDYEKPValLKVSAAfl--- 70  
Q54EN2               238 VDLMIEIPKSVFDSKDANDFKYFNKRNLYMLKIFNSVSKVSRFS--------DISFKNFNGDSNKQI--IVIRPKed--- 304  Dictyo...
EDO07370             140 IDLSIELPSSIFNPKDYINYRYLNKRNAWLCKLYDDMQSLLCADdfrkqfgeNITSSLd-yDNYKVKihLIFSVN----- 213  Babesi...
WGS:AATM:SJAG_03156  165 IDLLIEIPGDLFTDKDYLNLRYFHKRAYYLAKIAGKVTK--SLKds-----cEISFTFLNDDTRKPI--LEIVPKdq--- 232  Schizo...
O94676               163 YDLFLEIPESIFTQKDYLNGRYFRKRAFYLTCIAKHLLE--NLGne-----vKLEFVAFNDDIRRPI--LAILPEsk--- 230  Schizo...
WGS:AFWA:PNEG_03274  162 IDLAVEIPEKIFQKKDYMNYRYFYKRSYYLACLAEGIKKSPEFRg-------KLSFQLFNRDQLKPI--IVISYik---- 228  Pneumo...
XP_003290102         239 VDMTIEIPLSSLSSKDANDFKYFTKRNLYLLKVANELKKHPRFS--------DLSFKNFNDDSNKQI--IVIKPKed--- 305  Dictyo...
4M5D_A               279 slsdYNfYKTR-FSINLLIGFPYKVF-EPKKLLPN---------RNCIRIAQe--------------------------S 321  Saccha...
XP_004232410         164 ----VKlIGNAeFVVRIIPAATS-LF-SPTKLRLE---------RNNIHt----------------------------lK 200  tomato
XP_003516574         164 ----AKlVEVPgFFVRIIPSAKA-IF-SIAKLNLK---------RSNIHn----------------------------lS 200  soybean
2_pfamImport          71 --aeNGlKGAN-VCVRVIPVATPELF-KLAKLAPS---------RNNVRhep------------------------nmtE 113 
Q54EN2               305 ---pKTgARTK-FQIRIIPTIPNDLFnIYTKFHPNmscl--ffeRNNFKIETfkeddskeinnlnnnniidsknkkksfD 378  Dictyo...
EDO07370             214 --------NIR-FLIRIGAHIPSNTF-KISPLEIN---------RNNVRIPTttlvd------------------inesE 256  Babesi...
WGS:AATM:SJAG_03156  233 ----tGsAKKH-YRVRLLPYVNE-RF-RIQKLLPH---------KNGIRTVEst-------------------------- 270  Schizo...
O94676               231 ---gFAaTGKR-FTVFLIPTVRQ-IF-PVSKLLPH---------KNAIRDFMeh-------------------------- 269  Schizo...
WGS:AFWA:PNEG_03274  229 --dnEThNHKK-WNIFIIPSISQNVF-QSSKLSPN---------KSCI-------------------------------- 263  Pneumo...
XP_003290102         306 ---pKTgSKTK-FQIRIIPTIPKELFnIYTKFNPNiscifleseKDNIKIQTfkendsiyenneskkveddsktkkkrsF 381  Dictyo...
4M5D_A               322 KEQSLpaTPLYNFSVLSSSTHENYLKYLYKTKKQ 355  Saccharomyces cerevisiae S288C
XP_004232410         201 QGDALqaTPRYNNSILEDLFLEDNAEFVKRTFSG 234  tomato
XP_003516574         201 DGTALlaTPKYNSSILEDMFI-EDVEFINNYFLG 233  soybean
2_pfamImport         114 QEMKQcsTPMYNNSILEDMMVRRHTRELHAALKE 147 
Q54EN2               379 EIKR---TPFYNNSILEDIFINDHMQLINEKCEN 409  Dictyostelium discoideum AX4
EDO07370             257 QSNTLwpTPTYNSSISEDLQRDAIESRITETNHK 290  Babesia bovis
WGS:AATM:SJAG_03156  271 eDHSLlpTPKYNYSILEDTSLGYYAKCVKEVASS 304  Schizosaccharomyces japonicus yFS275
O94676               270 eE--LkpTPFYNNSVLEEQNLLFYRDLVKKYSVN 301  Schizosaccharomyces pombe 972h-
WGS:AFWA:PNEG_03274  264 -ASVDcpTPNYNFSILSDCTINQHHTVQYTCLQS 296  Pneumocystis murina B123
XP_003290102         382 DEIKR--SPFYNNSILEDILLNDHMQLINEKCEN 413  Dictyostelium purpureum
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