3KVN,3QQ2


Conserved Protein Domain Family
Autotransporter

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pfam03797: Autotransporter 
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Autotransporter beta-domain
Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.
Statistics
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PSSM-Id: 397736
Aligned: 596 rows
Threshold Bit Score: 47.7581
Threshold Setting Gi: 14195040
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3KVN_A          359 GFVGGGGQRLDfDSQDSAASGDGNGYNLTLGGSYRIDEAWRAGVAAGFYRQKLEa--gAKDSDYRMNSYMASAFVQYQ-- 434  Pseudomonas...
CAM96166        602 VWVKGLYSDADqGSRDGVAGYNAYSSGIVIGADGKLTPDLTLGLAYSYINSKVn----GLYNKTDVDAYALTAYGSWN-- 675  Pseudomonas...
WP_044623173    458 AWTSLIVGYGS-QSSGDIHGYDLNTYGINIGIDRVFDSEKLFGVSIAYARSNSDi--kDTGNSKDIDSLQGMIYTGWF-- 532  Photobacter...
WP_012210402    464 FWAQTLYTHGRqGNEADIFGYQTNAYGINIGMDRRFRDEALFGVAFGYQNSHINi--nGYGNTKDVNSYEAMAYTGWF-- 539  Salmonella ...
Q0WIL1          450 FWAQTLYAHSRqSSGTYTPGYQTNGYGINVGVDRRFNDESLFGVSLGYQNANINi--hSYGNEKDVDSYELMAYTGWF-- 525  Yersinia pe...
WP_012368257    444 SWANILYGYGTqSQQGGINGYNTYRTGIQIGTDYEINQDALIGISLAYNYAKADa--kQRNASKEISHFEFMPYAGWY-- 519  Proteus mir...
EJM97463        436 LWGQLLGNKASmNGTGQAGGFHSSGYGLILGADRQLGPQVVLGGALAWLHNDLKgegsNTGSDVKLDSYQLAAYGSWRp- 514  Herbaspiril...
WP_008997073    365 LWGQLLFNAAKrDVSPGASAYSANSTGIIAGVDLNGTSNLALGAALSWVHSKANgkgdTTGSNTRLDSFQATGYFTWQpg 444  Novosphingo...
jgi:Ent638_3385 695 VWGQPFGGYARqDSTVEVSGYSAKFGGLIMGADRSLGDDWRLGAAVNYSNTSVHgkgnLNGNTSTADNYGVIGYAGFT-- 772  Enterobacte...
WP_011906540    662 AWGQVFGGHANqGMVDSVSGYKANYSGLVLGVDRAMGDAWRVGGALTYSYTSVHgednLSGNKTGVDSYGLIGYASYT-- 739  Enterobacte...
3KVN_A          435 ---ENRWWADAALTGGYLDYdDLKRKfalg---ggerSEKGDTNGHLWAFSARLGYDIAQqadSPWHLSPFVSADYARVE 508  Pseudomonas...
CAM96166        676 ---QGPAFVDGSVTIGKNEN-TSKRDiad-------tvAKGDYDSDLFGINVLGGYGFNFd--NGFLVEPRAALRYSNLK 742  Pseudomonas...
WP_044623173    533 ---NERYFIDGNVNIGTNTI-NSTRSigtstgyegntQAKAEYDANQVGYQVMAGMKFDL---DVVKVEPRVAYNYQWLR 605  Photobacter...
WP_012210402    540 ---NDRYFINGNINMGYNKNsSTRNIgslng-yqgntKAEADYNSLQMGYQASAGITFDL---DIVKLQPRVEYNYQWFR 612  Salmonella ...
Q0WIL1          526 ---DDRYFFNGNVNMGYNSN-SSTRNigentgyqgntKATADYNSLQMGYQVKAGMTFDL---DVVKLQPSVAYNYQWLR 598  Yersinia pe...
WP_012368257    520 ---SDTLFLNGNLNIGYYTV-DSERDiggntgwqgntKAKGDYSGVQLGYQINAGTYLDF---DFIHIKPMLTYQYQWLN 592  Proteus mir...
EJM97463        515 --rGGQGYLSGIASVARNNY-DQARAvdf------lgTASASYRGWQAQAKLETGYDLPMs--AGLTVTPLLSLQAARIS 583  Herbaspiril...
WP_008997073    445 dadKAGLTIDGQLGFGYNHY-KQQRRidf-----lgrTASASFDGQQYLGNLRIGYTIPVs--KTASFTPFAGLRAVHLS 516  Novosphingo...
jgi:Ent638_3385 773 ---GDPWYLNLSAGVNRQNY-TSVRRadft---gfsgAAQGKFNGQSVTLQTEFGYPLTLq--AGVVLTPLASLTYGYQH 843  Enterobacte...
WP_011906540    740 ---GDPWYVNLSASVTQQRY-DTSRKvnmt---gysdSAWGKFNGQQYVTKAEFGYPLAVa--DTTTLTPLANLSYSYQT 810  Enterobacte...
3KVN_A          509 VDGYSEKGa-SATALDYDDQKRSSKRLGAGLQGKYAFGS---DTQLFAEYAHERE-YEDDTQDLTMSLNSlPGNRFtleg 583  Pseudomonas...
CAM96166        743 IDGYTEKN--SSAALSVGGQRIEVGEIGGGVRVAKDFSFmngTLKPSATAMAYHD-FIGDKANTTSTYTLgGS--Pf--v 815  Pseudomonas...
WP_044623173    606 VEDYNETG--SPASLKYDRTSYSVKQLGAGVTAFNTYDMaygQFTPLFSLMAYFD-MDDDERIRESAALTmDTSTDrf-v 681  Photobacter...
WP_012210402    613 VEDYAESG--SPASLEVDRQSYSVKHLGAGFTAFNTYDLafgKFTPSLSLMGYRDlNDSEVITETAGLVMdQGKGKgrft 690  Salmonella ...
Q0WIL1          599 VDDYAEFG--SPASLEVDRQSYSVKHLGAGLTAFNTYELgmgLLTPSLTLMGYRDlNDTEIIVKKAGLTTdQGKGKgrfi 676  Yersinia pe...
WP_012368257    593 IDSWEETGstLSMRTYGQRYAVNQLGGSVALWNDYQTSYg--KLTPSLNLRYIKDiAGNNDINQRHSLTYfNTGGStf-d 669  Proteus mir...
EJM97463        584 NDGYSESGl-GAASLNVQRQGFSNLDSELGVRLSSYTDTgwgRLTGDWQTGWVHS-FSNDAIATTSS----MGGVSf--v 655  Herbaspiril...
WP_008997073    517 NNGYTETGg-GAANLEVRKLKVDTVGHELGIQGSAIFDSapgRFMPSLKIGWAHN-YVNGPIPLSAVLGGvAFt------ 588  Novosphingo...
jgi:Ent638_3385 844 VDGYKETGg-NGMALDVGSSHAQSVVSDIGARIEKTFATglgNLTPFAQVTWLHQ-YDDRQVSSRASYAAdTVGETsf-t 920  Enterobacte...
WP_011906540    811 LDSYKESSg-NGSALSVESSHNNAFRSGLGAKLEKSFQTgigDIVPYVQAVWTHQ-YDSKQSTTNASYAAdTIGETsf-t 887  Enterobacte...
3KVN_A          584 Y---TPQDHLNRVSLGFSQKLAPELSLRGGYN 612  Pseudomonas aeruginosa
CAM96166        816 SsgaSSARNSLELGLGADYSI-GAVTVGASYS 846  Pseudomonas fluorescens SBW25
WP_044623173    682 IygdAVGGDIIEAKFNANLNMGNGLSASTGLT 713  Photobacterium gaetbulicola
WP_012210402    691 ItgdSIGNDIFEAALKSSLTLKNNIILDGNLN 722  Salmonella enterica
Q0WIL1          677 VegdSVGNNIFEAKMNSNLQLKNNLSLDGNIN 708  Yersinia pestis
WP_012368257    670 IkgnTVGGDIISAELGANLDITQSLNLGTTMG 701  Proteus mirabilis
EJM97463        656 StaeRLPKDGAHIVLRGTLQRSNNLSYAVGYE 687  Herbaspirillum sp. YR522
WP_008997073    589 StssRGGRDGATVGAGLAFMRDDQIKIGVQYD 620  Novosphingobium sp. Rr 2-17
jgi:Ent638_3385 921 TkgaSPVEDMAGVAIGSTLYEANELNLDARYD 952  Enterobacter sp. 638
WP_011906540    888 TfgaSPVEDTADLSLGTTVLNSDTLSVTARYT 919  Enterobacter sp. 638
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