Conserved Protein Domain Family
Competence

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pfam03772: Competence 
Competence protein
Members of this family are integral membrane proteins with 6 predicted transmembrane helices. Some members of this family have been shown to be essential for bacterial competence in uptake of extracellular DNA. These proteins may transport DNA across the cell membrane. These proteins contain a highly conserved motif in the amino terminal transmembrane region that has two histidines that may form a metal binding site.
Statistics
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PSSM-Id: 397716
Aligned: 76 rows
Threshold Bit Score: 65.319
Threshold Setting Gi: 81600312
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q080T1         205 LIFGDKSALTSQRWQQLQQTGAGHLVAISGLHLSVVFGlfygILIGISRYAfs-wQHLGKIQlaMVFAAVFTLGYGYLSG 283 Shewanella fr...
O83356         289 LLSADSVFLSDEMRVAFRHAGLAHVLALSGMHLSLVGA----SATFLGRFI-----GTRHRG--MQGAFFAMLVFVWFAG 357 Treponema pal...
CAJ54920       105 LLFGDRFFLSHTLNAVTCYTGLAHSLALSGQHLAVISIasitIIIILIKILpcffLSLPRYKaiPLFSLPFALLYLWIGG 184 Lawsonia intr...
Q5WHH2         211 LTLGERFYVEEDVIEAYSTLGIIHLLAISGLHVGLVTG----AAFFICIRI----GLTRERA--ALFMLILLPIFAILAG 280 Bacillus clau...
P39695         208 LTVGDRFYVEDEVLTAYQKLGVVHLLAISGLHVGILTA----GLFYIMIRL----GITREKA--SILLLLFLPLYVMLTG 277 Bacillus subt...
WP_022544211   212 LVFGERGLMDTSLLEDYQKLGIVHLLAISGLHVGLLAA----MILYIGKRA----GVPSKRM--KFLLLLFLPVYAVLTG 281 Bacillus infa...
tigr:GBAA_4551 207 LLFGDRQQMTFEVEGQYQQFGLVHLLAISGSHIVLLMV----IVYFILLRS----GVTREIA--TVCLIFFIPIYMILAG 276 Bacillus anth...
Q8Y740         195 LISGEKSGFSPEMYEVYQQMGVVHLLAISGLHVNLLIG----AIYFLLLKF----GVTRERA--ITFLLVFLPFYVILTG 264 Listeria mono...
Q8F8Z2         132 LIFGESKQLSQEFKTKAKEGGILHLFAASGLHLGVLMG----VQFRLLSLIp---SLGYNTP--RIIPLLTGFLYLSALG 202 Leptospira in...
CDE20771       178 ILLGEKSGMDQEMKELYQVNGIGHILAISGLHLSFAGL----GVYRIARRM----TGSYKTG--GITGGILLCLYVMMIG 247 Dorea longica...
Q080T1         284 FAIATQRALLMLFLLLIFSFI---KQFSHHWDRLAYALFFVMLVDPFASLGAGLWLSFGALVIILLSVkpdsvdqpSNLD 360 Shewanella fr...
O83356         358 ISPSLARALGMTLVLMGGQMA---YVRVGLFSVLCAVLSIHMLIAPHDVQTLSFMLSYGALAGIVLLG--------SEIT 426 Treponema pal...
CAJ54920       185 APPSLLRATIMLFIWSIYLIQ---NKPICFLDIAIIALICLILFDPQGIYHIGIQLSFLAVLSISFFN--------PLLQ 253 Lawsonia intr...
Q5WHH2         281 AAPPVVRASAMAFVFFLFALR---KWRIHPLFGFATIYFLYLLLDPYKLFQLGFQLSFLVSFALIFSA--------KTIQ 349 Bacillus clau...
P39695         278 AAPSVLRAALMSGVYLAGSLV---KWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAVSFSLILSS--------SIFQ 346 Bacillus subt...
WP_022544211   282 GAPSVTRAVLMLMCMLIYSLAargKKKLQPIDAVSSVFAVCLFFSPHIVYEPGFQLSFCVSFALIISA--------PSIF 353 Bacillus infa...
tigr:GBAA_4551 277 ASPSVIRASITGVLMLIAFMC---SIRLSSLDALSITAICMLIFDPYLVFNIGFQFSFVGSFALLLSA--------PLLL 345 Bacillus anth...
Q8Y740         265 ANPPVIRAATMTALLLLSEKY---TTKWSSFSAICLSFILFFLLQPYVMKEVGFQLSYTVSFGIILSS--------RQIL 333 Listeria mono...
Q8F8Z2         203 YPTSLARAWIFAGMLLFQGLF---FRKLRPVDLLLGSAWILWLLDPIRFYSVSFCLSFGAVTGIFFFS--------YPIR 271 Leptospira in...
CDE20771       248 MTVSVIRAWVMFVFRIGADIT---GRHYDMPTALAASAVLTVGIHPLYLYDGGFWLSFGAVFAVCTVI--------PVLE 316 Dorea longica...
Q080T1         361 PVLVNRSIDVPELTLtdrciekvmllkdnilhglgilwsIQWRLALLLGILQGILFGGIAPHSIWLNMLLVPWFSLVVIP 440 Shewanella fr...
O83356         427 EMMSGLIPRPLASLLg-----------------------TSCSAQFFTAPIVLSVIGYFAPIGVLASCVVSPLIALFLIG 483 Treponema pal...
CAJ54920       254 KCWKAIHKRISTTITseilystitt----sikiiiftigTTLIVQICTLPLCLYVFGYIP-IWFPLNIIWLPILGIFVLP 328 Lawsonia intr...
Q5WHH2         350 TANGGYLRQMCT---------------------------VTTIAQFAGLPLIFFHFYEWSPFSLLLNLVYIPLVSFIVLP 402 Bacillus clau...
P39695         347 QVKTSLGQLTI----------------------------VSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFYTFCILP 398 Bacillus subt...
WP_022544211   354 KNLNHWISQSVA---------------------------VSLAAQLASAPIILFFFYEISLFALFANLLYIPFFSFILLP 406 Bacillus infa...
tigr:GBAA_4551 346 ESGNGVIRNSIY---------------------------ISLISQLVSTPILLYHFGYYSPYSIFLNILYVPFLSLIVLP 398 Bacillus anth...
Q8Y740         334 AQQQNAFTKSLS---------------------------ISFISTIMSSVVMMYHFYSFSWVGIFFNLIYVPIFTIIILP 386 Listeria mono...
Q8F8Z2         272 IACNFLSDENKISYFlke------------------nlsISFSAGLGTMPVLLLAFESYSFGSILLNLIMVPLAGIL-LP 332 Leptospira in...
CDE20771       317 NEMRCKSLC------------------------------AGLGINVLLWPVILYNFFEIPVYSILLNLIILPLMSVVLTC 366 Dorea longica...
Q080T1         441 LTLLSFCIWLLAlwilwvlgidtasLQSFSLMIFQwaNLS-----LEPFAWLL-QLSDDLPLnqLVL--TEKELAGGMFF 512 Shewanella fr...
O83356         484 GSVALCCSLAVP-------------AVAPFLSW----GVYffgegLCAVVRFF-ACAPL-----VYV--QSACGHVCAAL 538 Treponema pal...
CAJ54920       329 LAFVSLLFCSLQc-----------tSIGILCINLA--QIP-----CEILIRLLlSLKNTEIIspIWL--PRPSWTMLLGC 388 Lawsonia intr...
Q5WHH2         403 FSFLSLIAFVWLp-----------eQVNLFIGL------------LESLLTFVhPTLLKLSEstFQLvlGKPPVWLVVAM 459 Bacillus clau...
P39695         399 GAVAGVLLLSLSa------------SFGRLFFSWF--DLL-----ISWINRLI-TNIADVDVftIMI--AHPAPVLLFLF 456 Bacillus subt...
WP_022544211   407 GILLGFLLHILSg------------GNAGLILQVL--EWS-----AGMANLAA-GKLGSLPGavLVL--GKPSGPALAMY 464 Bacillus infa...
tigr:GBAA_4551 399 CSIIILICLPIIp------------FLAKSFANVL--SIG-----LNLSNDFL-SYCESLPFtrLNF--GQTPILLVALY 456 Bacillus anth...
Q8Y740         387 GCLTVFVLSFFSae---------ifHFPEVVL-----TFF-----IQLVEKLT-YIFAKIPHqtIVT--GRPNILILMLI 444 Listeria mono...
Q8F8Z2         333 ILYFSLLIQKTKl-----------iLLTEPIWSIT--EFL-----IQILIYLS-ENLSK-PLgfYKE--MKGSVWIGITG 390 Leptospira in...
CDE20771       367 GMIGSFIKMAGW-------------IPGKWILWIC--RCI-----LWVYDKCC-VFTIKLPMarWVA--GRPDKRRIFIY 423 Dorea longica...
Q080T1         513 VLALMLLVLRRYVP 526 Shewanella frigidimarina NCIMB 400
O83356         539 FSFLLGGGLLEAAR 552 Treponema pallidum
CAJ54920       389 YLILLSIGIKLGRT 402 Lawsonia intracellularis PHE/MN1-00
Q5WHH2         460 YGALAFAFVHWQEQ 473 Bacillus clausii KSM-K16
P39695         457 TVTIILLLMAIEKR 470 Bacillus subtilis subsp. subtilis str. 168
WP_022544211   465 ITGVPALLIIWERK 478 Bacillus infantis
tigr:GBAA_4551 457 CVSIISVLMVWERR 470 Bacillus anthracis str. 'Ames Ancestor'
Q8Y740         445 IITIIIFFNQWQKk 458 Listeria monocytogenes
Q8F8Z2         391 WILLCIKILYysyf 404 Leptospira interrogans
CDE20771       424 YLVLMTVILILKfk 437 Dorea longicatena CAG:42
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