1J3L,3C8O,1VI4,3K4I,1NXJ


Conserved Protein Domain Family
RraA-like

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pfam03737: RraA-like 
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Aldolase/RraA
Members of this family include regulator of ribonuclease E activity A (RraA) and 4-hydroxy-4-methyl-2-oxoglutarate (HMG)/4-carboxy- 4-hydroxy-2-oxoadipate (CHA) aldolase, also known as RraA-like protein. RraA acts as a trans-acting modulator of RNA turnover, binding essential endonuclease RNase E and inhibiting RNA processing. RraA-like proteins seem to contain aldolase and/or decarboxylase activity either in place of or in addition to the RNase E inhibitor functions.
Statistics
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PSSM-Id: 397690
Aligned: 381 rows
Threshold Bit Score: 65.9971
Threshold Setting Gi: 502713539
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1J3L_A         6 TDLSDLypege------------alpxvFKSFGGRAR----------------FA-GRVRTLRVf-------------eD 43  Thermus thermop...
WP_004249461  24 VDILDSlgktivln-------sqlksinLENF---------------------YSvGQAYTVQWklirkqksilnkqp-- 73  Proteus
EOR01754       7 TTISDAlyklcpaa------dtggylpdLKLFAGSHC----------------LS-GPVFPVQF---------------E 48  Wallemia ichthy...
Q75AA2        13 cDVADGl---------------------LNFCGIDDGgflgnltq-wsgseqgTLvGPAYTVLFdkvenvd--eevnyiD 68  Eremothecium go...
CCK72706      16 CDISDGl---------------------LNLYDIPTGgyfpnlvqrsksgsdkTTvGKAYTVLFapvddpr--dtvnfiD 72  Kazachstania na...
CCC71739      14 sDIADGl---------------------LNLHKDGTGgflpnlt---rrsgkgTTcGIAYTVLFvpiddpr--ptinyiD 67  Naumovozyma cas...
CCD22986      17 CDIADAl---------------------LNLYKIKGGsyipnlt--rqsaftePLvGPISTVLFvpiddpr--painyiD 71  Naumovozyma dai...
Q6FRC7        16 cDVSDGl---------------------LHYCKIDDGgffpdli--qrsgphkTIvGPAYTVLFasvddpr--pevnyiD 70  [Candida] glabrata
Q6CQX7        14 CDISDGl---------------------LNLYGITNGgyfpnlv---rrsgsgTIvGRAFPVLFghknatqdkpsvnyiD 69  Kluyveromyces l...
WP_011729832  14 ADIVDAmgrlhrhrchlldlvsptpgrrLF--------------------------GPAVTISYfpacsaalppdch--- 64  Mycolicibacteri...
1J3L_A        44 Nalvrk------vleeEGAGQVLFVdg----------ggSLRTALlGGNLARRAWEKGWAGVVVHGAVRDTEELREVPIG 107 Thermus thermop...
WP_004249461  74 ---stweqvssflvpeiTDAKGLFYiagg-------helITEAALaGGMSCTYFEKLGFEGVILGGAVRDKKDLTNLTIP 143 Proteus
EOR01754      49 YkwsnpapmaehfvdaCPPGSVLLLcp----------psDATNACfGGLLASSAKTKSIAGVVANGRVRDLEELESSGMS 118 Wallemia ichthy...
Q75AA2        69 S---------------LPRGVVLVIglpleqqlptaphvIVSQALyGGLMSTRAQYLGSRGTIVFGRVRDVDEHRQLNYP 133 Eremothecium go...
CCK72706      73 E---------------VPAGSVMVIaltpplqrdvapyvKPTVAVfGGLMATRAQHQACRGCIVFGRVRDMSEFRDLSFP 137 Kazachstania na...
CCC71739      68 V---------------IPADSMLVLalpvsmqkayapfvTTTQAMyGGLMSTRAQYQGCKGTVVFGRIRDVEEHKNLNYS 132 Naumovozyma cas...
CCD22986      72 N---------------LKPGSVLMLgfplefqlkyapyvTMSEAIyGGLMSKRAQYQGCNGTIVFGRIRDVDEHIALKFP 136 Naumovozyma dai...
Q6FRC7        71 N---------------IPAGAFMIIaleksl---qekpeQITQALyGGLMANRAQYQNSAGTIVFGRVRDLGEHKECGQP 132 [Candida] glabrata
Q6CQX7        70 N---------------VPAESIVTIgmtedlqlssapytKPIQGMyGGLMSTRAKYLGSHGTVVFGRIRDIEEHKALDHS 134 Kluyveromyces l...
WP_011729832  65 ----nfrrlfyqaierGGEGCVLVLasn----------gftEVSLgGGTKLSRAENHRLAGVLADGRLRDFAELEQYDLA 130 Mycolicibacteri...
1J3L_A       108 LLALAA-----TPKKSAKEgk----geVDVPLKVl-----gVE-------VLPGSFLLADEDGLL 151 Thermus thermophilus
WP_004249461 144 VIATNL-----TP---TDTqgayfvseTGTQCTIe-----hAT-------ICSGDLVISDPNGTV 188 Proteus
EOR01754     119 IFAKGTsvcgqSPFLVPVK--------AGEPVQIehenghtMS-------VKPGDQLFADRNGVI 168 Wallemia ichthyophaga EXF-994
Q75AA2       134 VFSHALgvcapRMAVKPAK--------IGVALPI-------LMpdgsvrhLNPGDYVVADENGVV 183 Eremothecium gossypii
CCK72706     138 VHSYGVgacasKLTVKPVA--------VNVDLDM-------LCsdsavqtIKPNDLIAADEHGVV 187 Kazachstania naganishii CBS 8797
CCC71739     133 VYSYGVgacapKAAVKPVL--------TNTPLQI-------LTsdgevrvINPGDIVVADDQGIT 182 Naumovozyma castellii CBS 4309
CCD22986     137 VFSYGVsacsaNGRFKPIL--------MDGLLKI-------VNfdnkpmeLSSSGYVICDKNGAV 186 Naumovozyma dairenensis CBS 421
Q6FRC7       133 LFSLGVgtcapKKAVKPVA--------TNVSLPI-------LLpngctsaISPGDVLVADENGVV 182 [Candida] glabrata
Q6CQX7       135 VFSYGIgtcapKAVLKPIS--------YNCELKI-------KIsdgttetINPGDYLVCDDHGMV 184 Kluyveromyces lactis
WP_011729832 131 VYCRGE-----TTRWGGDTvtp---feANHPVVIg-----gVA-------VFPGDYIFADTSGAa 175 Mycolicibacterium smegmatis
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