5Y31,5Y31,5Y31,5Y31,5Y2Z,5Y2Z


Conserved Protein Domain Family
EPTP

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pfam03736: EPTP 
EPTP domain
Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.
Statistics
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PSSM-Id: 397689
Aligned: 215 rows
Threshold Bit Score: 29.3279
Threshold Setting Gi: 260828093
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5Y31_B       490 KFVKFQELNVQaPRSFTHVSINKRNFL-FASSfKGNTQIYK 529
ROL42204     225 DFIPLHSVPTE-SLSVDTFSHKNDVYVaIAAPnAESCMVLQ 264 Anabarilius grahami
XP_029311039  99 DFVLHQSVASE-SLSVDTFSYKNDVYVtIAAPsAESCMVFQ 138 Cottoperca gobio
XP_006629880 242 DFVLHQSLAFQ-SLSVDTFHYKNDVFAaIAAPnTENCMVMQ 281 spotted gar
TKS68233     140 DFVRHQSIPIQ-SMSADIFSFKEDIYVaMAAPnSNSCVVME 179 big head croaker
XP_005997930 196 DFVAHQILPYQ-SVSVDTFTYKDDVYVaIAQPsMENCMVLE 235 coelacanth
KAE8629285   236 DFTVHQVLSYH-SVSVDTFQYKNDVFVaIAQPsMENCMILE 275 tropical clawed frog
XP_003224986 217 DLVLFDTLPEQ-SLSVETFTYNGEQNLvVAQPfTGRCSFLE 256 green anole
XP_010406656 119 DFVMHQVLPFQ-AVSAEPFTYASDLYVaLAQPsASSCSILK 158 Corvus cornix cornix
VTJ77143     118 DFVLYQTLSFP-AVSAEPFLYSSDLYLaLAQPgASACTILK 157 woodchuck
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