6R2N,3B8A,4JAX,5ZQT,1BDG,3HM8


Conserved Protein Domain Family
Hexokinase_2

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pfam03727: Hexokinase_2 
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Hexokinase
Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.
Statistics
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PSSM-Id: 397683
Aligned: 420 rows
Threshold Bit Score: 86.8185
Threshold Setting Gi: 378754919
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6R2N_B                 223 VIGCIFGTGTNGCYMEKLENIHKLDPASreellsQGKTHM------------CINTEWGSFDNelnhLP--TTSYDIKID 288 Kluyv...
Q73JR5                 206 HIGFVLGTGLNSAYIEYG-KIEKLKTTEf-----YDKPQI-------------IVCESGKSNKi------pQSKFDKILS 260 Trepo...
SLUandSVAtrep:TPE_0072 207 FIGFVLGTGLNSCYIEYG-NIEKIKDTPf-----YGKPQM-------------VVCESGKSCKi------kQSEFDKELS 261 Trepo...
WP_013968453           224 VIGFILGTGMNVAYPETR---------------------IpkigfdapkspqIVVCETGSFHPr------yLGRLDEEFD 276 Trepo...
WP_015708748           223 MIGFILGTGFNTAYPEKS---------------------IpkigfesetapqIVVCETGGFMPr------yLGYLDKEYD 275 Trepo...
WP_015710875           222 VVGFILGTGFNTAYPESS---------------------IpkikfesktnpqIVVCESGTFASr------yVGFLDKEYD 274 Trepo...
EEA05954               328 VIGIVIGTGINACYIEPMSLFYGYK------------GV-------------IINTECGDFTC----SNlpITDCDLVLD 378 Crypt...
ESS33670               247 RVGLIIGTGFNACYVEPEASNYGYT------------GT-------------VVNMEAGNFH-----KDlpRNEIDVEVD 296 Toxop...
XP_966222              261 YIGIILGTGSNGCYYEPEWKKYKYA------------GK-------------IINIEFGNFD-----KDlpTSPIDLVMD 310 Plasm...
Q4N9S1                 282 RVGVILGTGFNICYEEDEYERFGYV------------GR-------------VINIECGNFD-----NElpQTPVDYEID 331 Theil...
6R2N_B                 289 QQfSTNPGFHLFEKRVSGLYLGEILRNILLDLEK----QeLFDlkesvlknNPFI-L-TTETLSHIE---IDtvENDLQD 359 Kluyv...
Q73JR5                 261 EN-SNLKNEYFLERMCSGRYLGELCSIALRAGSAe-----GIF-----------S-PrVNKMLLNSC---------DFST 313 Trepo...
SLUandSVAtrep:TPE_0072 262 ET-SNLKDEYFLERMCSGRYVGQVCSIALRTAARf-----GIF-----------S-EkANKDMINLP---------DFTT 314 Trepo...
WP_013968453           277 AT-LKNPGKYTFEKTMAGAYLGPLTLYMLKKAVQd-----GVL-----------V-FrKSGELLAMQ---------NLQT 329 Trepo...
WP_015708748           276 NT-TKNPGTYAQEKASAGAYLGPLSFHILKQAVRe-----GVL-----------S-FnRSDEFLAWP---------TLQT 328 Trepo...
WP_015710875           275 ST-TKNPGGYTLEKATAGAYLGPLTFHILKRAVKd-----GLV-----------K-FaKSKEFLDWP---------ALQT 327 Trepo...
EEA05954               379 WF-SDNRGDQQFEKMISGTYLGELCRLLFIRVLQdkapS-IFF--------Q--SkIiTTEDIANIAsfdEDntSINIDK 446 Crypt...
ESS33670               297 EK-THNRGKQQFEKLVSGYYIGEIVRVAAVRVFGarapEka---------sVRHS-I-HGETASTIR---DDh-SQDKAA 360 Toxop...
XP_966222              311 WY-SANRSRQLFEKMISGAYLGEIVRRFMVNVLQsacsKkm---------wISDS-F-NSESGSVVL---NDt-SKNFED 374 Plasm...
Q4N9S1                 332 FY-TSNRGRGKLEKLVAGAYLGEIIRRFMILYLReqapPkm---------wEIGT-F-TSVDASEIL---NDn-SEDLVI 395 Theil...
6R2N_B                 360 TRDALLK-AaD-------LET------TFE-ERVLIQKLVRAIS-RRAAFLAAVPIAAILIK--TNAlnqsyhcqVE--- 418 Kluyv...
Q73JR5                 314 EE--ISLfLkEqnhdkniFSGiieahsVSE-DYVKIYSICKCFF-ERAGRLSAAVIAAACIKtgKGKs-------PDkpi 382 Trepo...
SLUandSVAtrep:TPE_0072 315 EE--ISVfLkEqnnekniFSSfilkngISL-DYIKIYYICNAFF-ERAARLSAAVFAAAAIKtgKGKs-------PEkpl 383 Trepo...
WP_013968453           330 KD--LNAfMhNplagegpIGSlf---dRDErDALATLVFLTSIItERAALFAAAAVAAAVEKtgAGYd-------PFvpv 397 Trepo...
WP_015708748           329 KD--LNSfLrAplamegpIGElf---gKDErDALASFVYLCSIVtERGALLSAAILAATVERmdAGYd-------PFapi 396 Trepo...
WP_015710875           328 KD--LNAfMhAplamegpIGAlf---eKDEiDALRSFVYITSIItERAALLSAGVVAGAVLKssEGFd-------PFvpv 395 Trepo...
EEA05954               447 IQRF--------------IKSkynvilDTS-SCNTIKTMAIFVL-KRAAGLVATVIAALIKKienf------qngIT--- 501 Crypt...
ESS33670               361 SIQAIKE-C---------W-Gvt---mDLD-DIKCIWEICRLVF-DRSAAFAATLAVALCYR--TGrld----tgST--- 415 Toxop...
XP_966222              375 SRKVAKA-A---------W-Dmd---fTDE-QIYVLRKICEAVY-NRSAALAAGTIAAIAKR--IKiie---hskFT--- 430 Plasm...
Q4N9S1                 396 SKQVAKR-S---------W-Dve---lPKE-SLIALRKISEAAF-GRSAGFAAASICATARK--AKayv---tskTT--- 451 Theil...
6R2N_B                 419 -VGCDGSVVEHYPGFRSMMRHALALSpigpEGeRDVHLRISKDGSGVGAALCALH 472 Kluyveromyces lactis
Q73JR5                 383 cISADGSMFLKGFLIKERIFKSLHTClt-eKRgIYFVLKTNDEAVTLGTALAAFL 436 Treponema denticola
SLUandSVAtrep:TPE_0072 384 cIMGNGSVFSHGFLMKERIFKFLYEFlt-eKTgVHFVLKTSDNSVSLGTAIAGI- 436 Treponema pedis str. T A4
WP_013968453           398 rVAVEGTTYMVYKGMRPALESYLHTIls-aKApRSIVVSPVEQASLFGAAVAALS 451 Treponema caldarium
WP_015708748           397 rIAVEGTTYVRYKGMREALESYLHVMln-aGKpRSYVISPVEQASLFGAAVAALT 450 Treponema primitia
WP_015710875           396 rIAVEGTTYMIYKGMRTALEAWLHIMlt-kGKpRSYVIGPVEQASLFGAAVAALT 449 Treponema azotonutricium
EEA05954               502 -VAVDGSVWTRVPKFQNYTKENLNLIlg-eQVsQFIQFYEADDGSGKGAAILAAT 554 Cryptosporidium muris RN66
ESS33670               416 -VGIDGALYVKNQWYREAVEYYT-KLva-gDAaKNIHYCIADDGSGKGAALIADV 467 Toxoplasma gondii VEG
XP_966222              431 -CGVDGSLFVKNAWYCKRLQEHL-KVil-aDKaENLIIIPADDGSGKGAAITAAV 482 Plasmodium falciparum 3D7
Q4N9S1                 452 -VAIDGSLYVKNEWYRNKLQYYIDNVtr-pDLvGNVVLLSSDDGSGKGAAIAAAM 504 Theileria parva
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