6OM8,1MFZ


Conserved Protein Domain Family
UDPG_MGDP_dh_N

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pfam03721: UDPG_MGDP_dh_N 
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UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.
Statistics
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PSSM-Id: 397677
Aligned: 19 rows
Threshold Bit Score: 222.123
Threshold Setting Gi: 2495978
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6OM8_A  10 SKVVCVGAGYVGGPTCAMIAHKCphITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAAR-GRNLFFSSDIPKAIAEAD 88  Caenorhabditis elegans
O05973   1 MNITFIGSGYVGLVSGIIMGYLG--HNVTCLDNDDVKISKLNKKILPIYEAKLDEYLKHALeSDRLKFTNIYSNEFRNFD 78  Rickettsia prowazekii...
O26924   4 QRIAVFGLGHIGLPTAALFARAG--FKVTGVDINPETVEKVNIGRSPVLEPGLDELVAEVVgTGNLGATMDGERAAAESE 81  Methanothermobacter t...
Q2G1J4   1 MKLTVVGLGYIGLPTSIMFAKHG--VDVLGVDINQQTIDKLQSGQISIEEPGLQEVYEEVL----SSGKLKVSTTPDASD 74  Staphylococcus aureus...
Q57871  11 KRICVIGLGYIGLPTASMLAIQG--FDVIGVDINEKRVKEIKELSFKTTEKDLMTLVKGAI----NSGNLKVQTKPEKAD 84  Methanocaldococcus ja...
P27829   4 ATISVIGLGYIGLPTAAAFASRQ--KQVIGVDINQHAVDTINRGEIHIVEPDLASVVKTAVe----GGFLRASTTPVEAD 77  Escherichia coli K-12
P58591  10 rTISVVGLGYIGLPTATVLASRQ--REVIGVDINQHAVDTINQGRIHIVEPDLDMLVRAAV----SQGYLRATTEPEPAD 83  Ralstonia solanacearu...
1MFZ_A   1 xRISIFGLGYVGAVCAGCLSARG--HEVIGVDVSSTKIDLINQGKSPIVEPGLEALLQQGRqTGRLSGTTDFKKAVLDSD 78  Pseudomonas aeruginosa
O29659  43 MKIAILGSGYVGIVTGIGFAELG--HEIVFIDVDERKVEMLNSSKPPIYERGLEELMKKNR--GKYRATTDYREALESSE 118 Archaeoglobus fulgidus
O07248   1 MRCSVFGTGYLGATHAVGMAQLG--HEVVGVDIDPGKVAKLAGGDIPFYEPGLRKLLTDNLaAGRLRFTTDYDMAADFAD 78  Mycobacterium tubercu...
6OM8_A  89 LIFISVNTPTKMygrgKGMApDLKYVESVSRTIAQYAGG---PKIVVEKSTVPVKAAE-SIGCILREAQKNNe------n 158 Caenorhabditis elegans
O05973  79 AIFITVGTPSKE----LGEA-DLKYVYDAVDKVSKHINK---DCLIVIKSTVPPGSC---N-NIIAYLKAKG-------- 138 Rickettsia prowazekii...
O26924  82 VMIIVVPTPVNS-----ENTsDLSAVISAAETISRGLKK---GDLVIVESTVPPGACQnVVLPILEKTGLKVs------- 146 Methanothermobacter t...
Q2G1J4  75 VFIIAVPTPNNDd---QYRScDISLVMRALDSILSFLEK---GNTIIVESTIAPKTMDdFVKPVIENLGF-Ti------g 141 Staphylococcus aureus...
Q57871  85 VFIICVPTPCIEc--dGEKKcDLTYLNKAIESIKPYLEN---GNLIIIESTIPPGTTDdIYKKLSKd------------- 146 Methanocaldococcus ja...
P27829  78 AWLIAVPTPFKG-----DHEpDMTYVESAARSIAPVLKK---GALVILESTSPVGSTEkMAEWLAEMRPDLTfpqqvgeq 149 Escherichia coli K-12
P58591  84 AFLIAVPTPFLD-----NKQpDLSYIEAAARAIAPVLKR---GDLVVLESTSPVGATEqLSDWLSAQRPDLSfphqqgee 155 Ralstonia solanacearu...
1MFZ_A  79 VSFICVGTPSKK----NGDL-DLGYIETVCREIGFAIREkseRHTVVVRSTVLPGTVNnVVIPLIEDCSGKKa------g 147 Pseudomonas aeruginosa
O29659 119 LTFICVGTPSKG-----DGSiDLKYAESASKEIGKALKNndnFHVVVVKSTVVPGTTEdKIKPIIEKESGKKa------f 187 Archaeoglobus fulgidus
O07248  79 VHFLGVGTPQKI----GEYGaDLRHVHAVIDALVPRLVR---ASILVGKSTVPVGTAAeLGHRAGALAPRG--------- 142 Mycobacterium tubercu...
6OM8_A 159 LKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGlqavAELVRI 205 Caenorhabditis elegans
O05973 139 FSFNVASNPEFLREGSAVEDFLYPDRIVVGVNNKESE----ALLRKI 181 Rickettsia prowazekii str. Madrid E
O26924 147 EDFGLAYTPERALPNNTLHEMQNNARVIGGADPESAR-----RAAAL 188 Methanothermobacter thermautotrophicus str. Delta H
Q2G1J4 142 EDIYLVHCPERVLPGKILEELVHNNRIIGGVTEACIE-----Agkrv 183 Staphylococcus aureus subsp. aureus NCTC 8325
Q57871 147 KKIYVAHCPERVLPGSILKELVENDRVIGGVDEKSAE-----MAKEI 188 Methanocaldococcus jannaschii DSM 2661
P27829 150 ADVNIAYCPERVLPGQVMVELIKNDRVIGGMTPVCSA-----RASEL 191 Escherichia coli K-12
P58591 156 SDIRVAHCPERVLPGHVLRELVENDRIIGGMTPKCSE-----AAQrl 197 Ralstonia solanacearum GMI1000
1MFZ_A 148 VDFGVGTNPEFLRESTAIKDYDFPPXTVIGELDKQTG----DLLEEI 190 Pseudomonas aeruginosa
O29659 188 EDFGLAMNPEFLREGNAVYDFFNPDRIVIGVKDERTK----SVLEEL 230 Archaeoglobus fulgidus
O07248 143 VDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRa--eVAVREL 187 Mycobacterium tuberculosis
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