5OIZ,5LP4,2WAF


Conserved Protein Domain Family
PBP_dimer

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pfam03717: PBP_dimer 
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Penicillin-binding Protein dimerization domain
This domain is found at the N-terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.
Statistics
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PSSM-Id: 397673
Aligned: 69 rows
Threshold Bit Score: 89.684
Threshold Setting Gi: 122952969
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5OIZ_A         23 TVPAKRGTIYDRNGVPIAEDATSYNVYAVIDENYKSATGKIlyvektqFNKVAEVF-HKYLDMEE--SYVRE-------- 91  Streptococcus ...
Q81DA1         35 TSSAERGKIFDQNGAILATNKKVKSLYCTSNDEKLSKQDTSs-----tLAFFNQFSsEFQHDIST--ENIKSq------- 100 Bacillus cereu...
Q8Y763         66 skNVPRGSIYDRNYNLLVGNSAVKSITYTRSQQTQTAETLHv------AQTLEKLItVEPEKLTD--RDLKDywilthqt 137 Listeria monoc...
Q8CXD5         58 SVPVPRGRILDTNGNVIVDNNAMYSITYTPPKGVQAKDRLQl------AQKLADYIeMGQEDRL---KRITDrdkreyyy 128 Oceanobacillus...
Q9KD08         58 RIDAPRGLMYDRFGYVVVDNELELSLTYTSQSQTRDTEEMLd-----vARKLEQLI----EVDT---SKITErdrkdywl 125 Bacillus halod...
Q5KX46         55 sTPVPRGKIYDRFGRVIVDNTPQKAITYTRSKTTQPEEILDi------ARKLAQYI-D----IPDaeKKVTErdmkdywi 123 Geobacillus ka...
2WAF_A         55 tsSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKEt------AKKLLTYVsISSPNLTE--RQLADyyladpei 126 Streptococcus ...
Q9CIL7         81 ieGAPRGNIYDATGKALASTVAVQAVEFTRSQNATADEIYQv------ANKLATIL-S--NNIDV--ADLTTrdkkdyfl 149 Lactococcus la...
jgi:Lreu_1211  71 TNNVQRGMIYDSQGNVLVGNQTHQAITYTKGANVTTDQLYQi------ANRLGKYVsVSNKN-----SRLTDrneedyyl 139 Lactobacillus ...
Q38VZ5         65 TGNVPRGMVLDAKGRVLVGNSAKSAITYTKNMNVLADKMYAe------ANQLTKYL----TIDKL--DTLTErdqidyyl 132 Lactobacillus ...
5OIZ_A         92 -----------------------------------------------------------QLSQPNLKQVSFGAKGN-GIT 111 Streptococcus ...
Q81DA1        101 -----------------------------------------------------------LQQSCKKQTMNDIPLYS-DIT 120 Bacillus cereu...
Q8Y763        138 eslnrlsakeqaldsska---------------ykiqvdkvtkediasltsedlkvatiYKKMTTGYAMTESVVKNkDVT 202 Listeria monoc...
Q8CXD5        129 llnqkdvderlndidtsemdn---------advynhtleliteeeisdfsdddmeiiaiKKELDKAYSLTPQVIKNeDVS 199 Oceanobacillus...
Q9KD08        126 lqasreerlelvsleerkeidd-------pqeeyaleleritdehlnslteederilaiFRQMNQGYALTPQRIKR-DIS 197 Bacillus halod...
Q5KX46        124 lthpkeakrkvseqerkkladqgltqkeidkkvyewtldritkqdlaqiskaeleviaiKHEMESGYALTPQTVKSkGVT 203 Geobacillus ka...
2WAF_A        127 ykkivealpsekrldsdgnrls--------eselynnavdsvqtsqlnytedekkeiylFSQLNAVGNFATGTIATdPLN 198 Streptococcus ...
Q9CIL7        150 ansknlekianslsekekkdkhgn---dlsgsqiydvelskvkdsdlnftaeqtfaaklFKEMNSTTTFNTTKIATgSIT 226 Lactococcus la...
jgi:Lreu_1211 140 adkerlksvlkhvktsdadsed--------tkydkaleylskhpdsweltdqqknnariYAAMSGAYSLSTTYIKEtGVS 211 Lactobacillus ...
Q38VZ5        133 snpknlkkwnarlpksrkvaadgs---kipdktvyqstidlveksftglsdkqkqaaaiFKIMSGAYQLSTVYIKNdNVT 209 Lactobacillus ...
5OIZ_A        112 YANMMSIKKELEAaeVKGIDFTTSPNRSYPNGQFASSFIGLAQLH-------------ENEDGSKSLLGTSGMESSLNSI 178 Streptococcus ...
Q81DA1        121 ENELAFINKNKPN----NVIIKDEWIRYYPKHEIGSQVIGYVEND---------------LNSKHMAVGKSGIELQYEND 181 Bacillus cereu...
Q8Y763        203 DEEIARVSENMDS--LPGVDTTTDWNRYYTYDETLRSILGSVSTAkeglpkdkaeyylSQGYSRNDRVGKSYLEAQYESV 280 Listeria monoc...
Q8CXD5        200 AEEYATVAENLDK--LPGINATTDWDRLYPYDNTLSSILGGITSQeqgipaedvqaylSKGYSRNDRVGTSGIEQQYEDF 277 Oceanobacillus...
Q9KD08        198 EEEAHSIAEKLDE--LPGVDILRDSRRKYPYGNSLRSVFGNTGSIpreql----nnylAKGYERSDIVGTSYLELQYEDV 271 Bacillus halod...
Q5KX46        204 DREYAVVSEHLSE--LPGVNTTVDWDRKYVYDNTFRSVLGSVTEEdegvprerldyflARDYSRNDRVGKSYLEMQYEEV 281 Geobacillus ka...
2WAF_A        199 DSQVAVIASISKE--MPGISISTSWDRKVLE-TSLSSIVGSVSSEkaglpaeeaeaylKKGYSLNDRVGTSYLEKQYEET 275 Streptococcus ...
Q9CIL7        227 AEQQATIAEQEGD--LPGITIGTSWDRSYAQ-NSLTPLMGTITSQksgipaedldaylKKGYQRNDRVGTGLLEKGYESE 303 Lactococcus la...
jgi:Lreu_1211 212 AKELAAVGEHLNE--MPGVKIGTSWTRNYPQGTDIQSLTGTVSTTglpsde--vnsllAQGYSRNDSVGQSYLEKQFQST 287 Lactobacillus ...
Q38VZ5        210 DKEIAEISEHLTS--LPGINVGTDWERSYPNGDSMRSIIGHVSTEeqglpedginsllAQGYSRNDRVGTSYLEKQYESI 287 Lactobacillus ...
5OIZ_A        179 LAGTDGIIT-YEKDRLGN-IVPG 199 Streptococcus pneumoniae R6
Q81DA1        182 LKGKPGKTLiFKLN--NKkFLWN 202 Bacillus cereus ATCC 14579
Q8Y763        281 LAGSKSQSE-SVLDSKGN-IIET 301 Listeria monocytogenes
Q8CXD5        278 LRGRKEQIQ-YETRKNGS-IVGT 298 Oceanobacillus iheyensis
Q9KD08        272 LRGQKAVVEsTTTSSAGD-MIEQ 293 Bacillus halodurans
Q5KX46        282 LHGKKAKVK-NVVDKSGN-VISV 302 Geobacillus kaustophilus
2WAF_A        276 LQGKRSVKE-IHLDKYGN-MESv 296 Streptococcus pneumoniae R6
Q9CIL7        304 LQGTHSISK-VKFDKNGD-VSGT 324 Lactococcus lactis subsp. lactis
jgi:Lreu_1211 288 LAGSKSQTE-VTTD--GNdVTKE 307 Lactobacillus reuteri DSM 20016
Q38VZ5        288 LHGSKSQTQ-VEVGNNNQ-ILSS 308 Lactobacillus sakei subsp. sakei 23K
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