Conserved Protein Domain Family
Noc2

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pfam03715: Noc2 
Noc2p family
At least one member, Noc2p from yeast, is required for a late step in 60S subunit export from the nucleus. It has also been shown to co-precipitate with Nug1p, a nuclear GTPase also required for ribosome nucleus export. This family was formerly known as UPF0120.
Statistics
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PSSM-Id: 397672
Aligned: 123 rows
Threshold Bit Score: 205.044
Threshold Setting Gi: 74953755
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4UI93                      324 VDLLLKRCYSSHVKSVMNgITLKNYGLFKVSKNCISELYLNApFDNLYMFSFKTITNLAYNVRREwNNTGkekkpkkket 403 ...
EGI63392                    316 LEELLKTMYEKYVHTVKF-ISLNILPRINFMRQSLLEIYLLD-HNISYSHAFLHIRQLAIDLKNA-VTLK---------- 382 ...
XP_968623                   313 LDTVLKSMYMTYVKNSKF-VSVGSLACINFMRRSLVEMFALD-AGVAYQHVFLYIRQLAIYLRNA-ITVN---------- 379 ...
XP_002426891                335 LQKALKVMHMTYVRNTKF-VTPSSLPGINFMRQSLCEMFALD-NTISYHMVFLYIRQLAIHLRSA-ITQK---------- 401 ...
XP_001943867                337 LEIILKAMYVGYISNSKF-VTPNALPGINFMRQSLSEMFTIS-ESVSYNHAFLYIRQLAIHLRSA-VTLK---------- 403 ...
XP_002003590                331 LNHVLKAMYLAYVRNSKF-VSPNTLPGINFMRRSLVEMFALD-LNVSYQHAFLYIRQLAIHLRNA-VILK---------- 397 ...
Q17BU6                      383 LSDVLKNMYLAYVKNSKF-VSPNTLPGINFMRRSLTEMFTLD-MTVSYQHVFLYIRQLAIHLRNA-VILQ---------- 449 ...
WGS:AAAB:ENSANGP00000031827 386 LSNVLKVMYLAYVKNSKF-VSPNTLPNINFMRRSLAEMFLLN-FNVSYQHMFLYIRQLAIHLRNA-VILQ---------- 452 ...
XP_004930957                283 LDPVLKVMYMTYVKNCKF-VSPSTWPGINFMRRSLVEMYSLD-LDVAYRHVFLYIRQLAIHLRNA-IVVQ---------- 349 ...
XP_015786997                189 ISFIMKKLYLAYIKNCKL-VSKETWPMINFMQQSLVELYSLD-QGVAYQHAFIFIRQCAIALRNA-SAST---------- 255 ...
Q4UI93                      404 nskedkTkkplnvNTTILSVCSWGFIESVNIWINVLSRS---DNKMKTLIYPLVTVINSAIKIkISNKRQIPFVLHLLIS 480 ...
EGI63392                    383 ------N------KKNLQAVYNWQYINSLRFWTELMTKSk-dKSMLRSLLYPLVQIIIGTIKI-NPTAQYYPLRFYCLEM 448 ...
XP_968623                   380 ------K------KENIHAVYNWQFVNSLKLWGSFLSASy-hKMQLAQLVYPLVQVCLGVLKL-VPTAQYYPLRFHVVKI 445 ...
XP_002426891                402 ------K------KEAYKMVYSWAYISSLHLWADLFGIVp-kDSPLNSLIYPLVQIIIGTIKL-VPSAAYYPLRFHCCKI 467 ...
XP_001943867                404 ------K------KENIQSVYNWQYIYSLKLWTDVLCATl-nKKQLQTLVYPLIQIIVGCAKL-IPTVQYLPLRFHCISM 469 ...
XP_002003590                398 ------K------KDSFQAVYNWQFINSLRLWADLLGASa-nKPQLQPLIYPLVTITIGVIRL-IPTAQYFPLRFHCLQS 463 ...
Q17BU6                      450 ------K------KDSFQYVYNWQYINSLKLWSDVLAIAy-nKKELEPLIYPLVSIITGVIKL-IPSAQYFPLRFHCCRM 515 ...
WGS:AAAB:ENSANGP00000031827 453 ------K------KESLQYVYNWQYINSLKLWGDVLGSAhahGGALEPLIYPFVSITIGVMKL-IPSAQYFPLRFHCCRT 519 ...
XP_004930957                350 ------K------IENRQAVYNWQFVNSLRLWGDLL-AVn-nRPPLHPLIYPLVMVTINTIKL-VPTHQYYPLRFHCVEI 414 ...
XP_015786997                256 ------E------QDAFKTVYNWQYLQSLLLWSRLLTNLh-pSEVLKPLIHPLVQVFMGTIKH-LSVARYFPLRLHIVKA 321 ...
Q4UI93                      481 LNKLLDGTHKFIPIMSLLYHVLDNiKNIkqtvpseyfKNTlvtsninnpnklvkpfKllKSkgSLEKSEDIMVKLRLSGK 560 ...
EGI63392                    449 LITISKETGTFIPILPFLLEILES-YDF---------NKR----------------H--KTvmMKMKPISFDCILKISKS 500 ...
XP_968623                   446 LMDLSRDTGVFIPILPFILEVLSG-YDF---------NKK----------------H--QKv--SMKPIQFTFLLRVSKS 495 ...
XP_002426891                468 LINIRSKCDVFIPILPYLLEILRD-YNF---------KRE----------------H--KKl--TVKPLDFTCLLRCSKL 517 ...
XP_001943867                470 LTKLSRETGKFIPILPHILEVLTI-VDF---------QKK----------------H--SKt--SMRPMDFTCILRLSKS 519 ...
XP_002003590                464 LISLSKETHTYVPVLPLIVEVLRS-NTF---------NRK----------------H--TSv--SMKPLQFTCILRLNKS 513 ...
Q17BU6                      516 LLDLSAKTRVFIPVLPFIIEVLNS-NSF---------NEE----------------H--KKl--SMKPVNLTCLLRFAPA 565 ...
WGS:AAAB:ENSANGP00000031827 520 LIQLNAKTNIYIPVLPFLVEVLRS-HSF---------NED----------------H--KKl--SMRPVNLTCLLRFSPA 569 ...
XP_004930957                415 LMNLSKETETFIPVLPFLTEIL-A-YDF---------NKK----------------H--KKv--SMKPLDFSCILRLAKS 463 ...
XP_015786997                322 LIRLSTTTNTFIPVLPLITDVLDA-TNY---------EKK-------------------FKvtQKKNKIDFDCLTRVSQN 372 ...
Q4UI93                      561 SVNSPQIYKVLYKYVELILIDHLGILSLNPSFPEYTNCICYHLKRYIKS--PEVlndFRNTVNSLLKVLNETNVVVTKLR 638 ...
EGI63392                    501 QFIENDFKDGIIETIYHLILEHAASESHKIYFPELYTPCIIQLKEFLEKchVAM---YCKKMKLLLNMIEENRKHIETER 577 ...
XP_968623                   496 QMMENGFKDALIEAIYELLLEYLTTNSHSISFPDLSLLCVVQIKQFVKKcaNAN---YNRKMKQLLEKIEQNSKFIENER 572 ...
XP_002426891                518 QMKENGFKDAIIENIYSLLMEYLATECHRVSFPDVTVPAVIQIKKFLKTckYTN---YNKKLKSIVDKISENSKFIEGER 594 ...
XP_001943867                520 QLQENVFKDAVIENVHSAFMEYIVIEAHTISFPDIVVPFIIKMKDFLKNckNIN---YTRKLRTLLDKVKETSTILSEKR 596 ...
XP_002003590                514 QLAENGFRDEVVEQVCGLLLEYLAYQSSTLAFSDLVVPVVMALKAYLKEcrNAN---YVRKLKQLLDKIQESSRFIEQQR 590 ...
Q17BU6                      566 NIQENAYKDAVLDQIYELSLEYLAHESASICFPDMIVPVVTAFRSFCKStkVYK---YSRKIKLLSDKIVENAAFIEKER 642 ...
WGS:AAAB:ENSANGP00000031827 570 NIQENAFKDAVIDQIYELVLEFAANESASIGFPEIVLPIILQLRQYAKTtkQYK---YSRKMKQLSDKLMENYEFMEKRR 646 ...
XP_004930957                464 QLMENGFKDAVIDKLYALMLEYTANESHTFAFPDTILLAVIQLKQFLKScsVAN---YTKRFRQLLEKIEENARFIEQER 540 ...
XP_015786997                373 LTDEKLFVDGCINKSHELLLEYLSHQSHSIAFPELSYFTLRKIKKFVKKctVAS---HGKMMKKLAEKIEETSKLVEEKR 449 ...
Q4UI93                      639 EG----MDDAALEGFNVFE----PEKIPMYKYR 663 Theileria annulata
EGI63392                    578 SKa--tINLKSMAEITNWEnrtkTDGTAIAKFY 608 Panamanian leafcutter ant
XP_968623                   573 SKt--tLNITDFKQIEGWEaqvkTKGTPLATFY 603 red flour beetle
XP_002426891                595 KKv--nLKINDLKGVDAVEagirAKGTPFSKFY 625 human body louse
XP_001943867                597 GKs--gLLLHDLKGIEAWEsdikLAGTPMSVYY 627 pea aphid
XP_002003590                591 SKsnvtFDLKDAQAVQAWEqqvrNKRTPLDIYY 623 Drosophila mojavensis
Q17BU6                      643 KVl--pFRLKDIAEIQSWEatrkAKGTPLLTFY 673 yellow fever mosquito
WGS:AAAB:ENSANGP00000031827 647 LKm--dIPLKETDRIRAWEelvrAEGTPLAKFY 677 Anopheles gambiae str. PEST
XP_004930957                541 IKs--tVALDDESSIMAWEtsmkAKGTPLKLFF 571 domestic silkworm
XP_015786997                450 QHv--nFSLKDQNAINQWQseikDKGTPLSKYL 480 two-spotted spider mite
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