Conserved Protein Domain Family
Erg28

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pfam03694: Erg28 
Erg28 like protein
This is a family of integral membrane proteins, which may contain four transmembrane helices. Members of this family are thought to be involved in sterol C-4 demethylation. In S. cerevisiae they may tether Erg26p (sterol dehydrogenase/decarboxylase) and Erg27p (3-ketoreductase) to the endoplasmic reticulum or may facilitate interaction between these proteins. The family contains a conserved arginine and histidine that may be functionally important.
Statistics
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PSSM-Id: 397654
Aligned: 125 rows
Threshold Bit Score: 75.9961
Threshold Setting Gi: 1005951803
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009219484  13 GYLPLYLLVVSVAAIGNAAQNFG-TLHYTRRIYKGLFvpnpaltrgraaapttrsnpedsihklvpasstgkdvekanDQ 91  Gaeumannomyces ...
EGC36072       2 EFLSNWLIFVALYKFVSFFLIFK------DDVYKNQFnrd------------------------------------imKQ 39  Dictyostelium p...
Q54I19         2 ETFAIWLLMVGLYRVFMSFLILIqTDVLKKVIYPLKP-----------------------------------------IE 40  Dictyostelium d...
Q552F9         2 EYLQAWLLFIGFFRILCSFVGLVyP-EFMSVGYSRKNk----------------------------------------QN 40  Dictyostelium d...
Q54UK5         2 QLLQYFLFFIGCFRLFCSFKFLInPVSIFSYAYPNVKk----------------------------------------EV 41  Dictyostelium d...
XP_015784257   7 yttRGWLAFLSFMHVGTAFRCFTdRDFLRTKIFTSTT-----------------------------------------YK 45  two-spotted spi...
EFX79779       7 yTLRGWLAFVSFLDFAQALRSWF-----DKDVFLGSYyknfntst--------------------------nitdlenLP 55  common water flea
XP_008185879   8 yTFRGWLAFVAFMDLGVTFRSFF-----ENKCIIGTQtnlqa--------------------------------dehfIH 50  pea aphid
Q16NG9         7 yAFRGWIAFVAFMDLGTAVRCYI-----ERRSFLGDHset------------------------------------qfIE 45  yellow fever mo...
XP_014251518   7 YAFRGWIAFVAFMDLGVAVRSFI-----EKKCILGEYsftkt--------------------------------dgllEQ 49  bed bug
XP_009219484  92 MTPLAARLFAAWTFITGVIRLYAAYDVSNPVLYQLSLLTHIVAASHFLSELLVFKT-CPPSGPLV------FPIIAGS 162 Gaeumannomyces tr...
EGC36072      40 VNPLFCRAIQLWLAYTGAVSLLTSYHLDNKDLVFSCFISFLIPFPYLVNEFFIHKTyAKIHALHV------FPLCVTS 111 Dictyostelium pur...
Q54I19        41 VSPLFCRMAFMWVISNAILTITTSLNMDNKPLYFITWLTFVIGLSHFMLEQFYFKT-NTL-KSNL------SQLFFAT 110 Dictyostelium dis...
Q552F9        41 FSGLISRIFFLWIFTTGSITIACSIDITNRTVYFLTWLTFVTGLGHFLTEYFYFKS-NQI-KNNL------IQLFlal 110 Dictyostelium dis...
Q54UK5        42 FLGLFSRIAFLWFFTTGSMAIACSQDIENKTLFFFTWMTFVYGLGHHVVEYLYFRT-TEI-KNNLvqfslaFPLIIIM 117 Dictyostelium dis...
XP_015784257  46 NDITFDHLFGIYSIINAIILIQSSIYLYVYPVTRLVICAILAYVSLFTVESFVYKT-IQIQQTTL------FPFAFsg 116 two-spotted spide...
EFX79779      56 LPSSSARLLIAYSIQNGSILLLSAFCIHHWSMAVMAMFSLLLKIVYLMLEALKFKS-TPFNFHII------FPVIVdg 126 common water flea
XP_008185879  51 EELTLPRVLGMFSLLKALCLIHCSLFIHYKPMVSIGAMSMVLSIVLYLSEAIHYRS-TTLNFFIV------FPSILNg 121 pea aphid
Q16NG9        46 GDYTISRILGIYCILKAVALVHCTLYIHYKAVVSMGGCSLAITMVLYMTEALYFRS-TTLNFYVI------FPCILNS 116 yellow fever mosq...
XP_014251518  50 DDPTLPRVLGMYSILKAIALIHCTVFIHYIPVISMGICSILLTVLMYLSEALYFQS-ATLNFYIV------FPCVLNc 120 bed bug
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