Conserved Protein Domain Family
NPR3

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pfam03666: NPR3 
Nitrogen Permease regulator of amino acid transport activity 3
This family, also known in yeasts as Rmd11, complexes with NPR2, pfam06218. This complex heterodimer is responsible for inactivating TORC1. an evolutionarily conserved protein complex that controls cell size via nutritional input signals, specifically, in response to amino acid starvation.
Statistics
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PSSM-Id: 397640
Aligned: 72 rows
Threshold Bit Score: 328.837
Threshold Setting Gi: 342320453
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6FVA1        243 EFDIDFLAELCCPSREMCNTRFELTVDEYCFLGHPIHVDSSGNWRKSRKrnns------------lsksKRSGSLTGSRK 310  [Candida] gla...
GAC97587      205 GYDIDILASILNPRTALAHQKFELVVDDLAFLGHPVAAHPERGWDEEGNetlqsdrdsq-getstaqsqQRGRSGLRKEI 283  Pseudozyma hu...
KIS69018      205 GYDIDILASILNPRPELSHKKFELVIDDLAFLGHPVTPNKNGVWGDQDDesqddrvear-dektaahaqQRGRSGLRKEI 283  Ustilago mayd...
GAC76013      199 GYDIEILASILNPRPELAHQKFELIVDDLAFLGHPVAASKAGTWGEPDNhdghpgatdsddahaaapsqRRGRSGLRKEI 278  Moesziomyces ...
EST05284      203 GYDIELLASILNPRQELTHHKFELMIDDLAFLGHPVSLDRSDILGGQDDedadaeg-------hdrsagQRGRSGLRKEI 275  Kalmanozyma b...
EGN98979      132 GYSSEFLASMLCPQRSLCHQKFELRIDDLVFLGHPVGAESDGSWRFKSEklk---------------sgSRGRGSRNRDA 196  Serpula lacry...
XP_007842193   83 GYSSEFLAGILCPHASMCHQKFELVVDDLAFIGHPVCAEAGGIWHFKQEkpk---------------vsSRGRESHNRPT 147  Moniliophthor...
EFJ03428      127 GYNAEFLTNLLCPHVSMCHQKFELIVDELAFIGHPVCAYPDGTWKFKPEvgk---------------glNRGRGSRNRQM 191  Schizophyllum...
EPT01368      133 GYSAEYLAGLLCPQDSMCHQKFELVVDDLAFIGHPVCAEPDGSWRFKPKv------------------iNRGRGSRKGEA 194  Fomitopsis pi...
EFI27887      119 GYSGEFLASLLCPQSNKCHQKFELIVDDLAFLGHPVAANERGEWEFRPEptk---------------gsVRGREGKEKKA 183  Coprinopsis c...
Q6FVA1        311 RSGSKSSNHDKSFSAETPNSPESSKIiEEVGSLHKSRTLSNpq------nDHFTKDMTMFHVCFIMD-PNLI------EY 377  [Candida] gla...
GAC97587      284 RPFDPPNGIDGSND--------GTDIsASTGAKSRHASRTRiekpddapsSRAKAPLTQFHLVLVLDrPDPStalptmDL 355  Pseudozyma hu...
KIS69018      284 RPYDPSDDRVASND--------KIDKsAKTGAKSRNASLTRieqtndiptSRSKAPLTQFHLVLILDrPDPStavpgvDL 355  Ustilago mayd...
GAC76013      279 RPYDVPDGQTPAKEPDADSAKKGKSEpKTSDTEap--------------aSKAAAPLTQFHLVLVLDrPDPStamsgmDL 344  Moesziomyces ...
EST05284      276 RPYDVSDGGDASKDAACSLRQNGGKTeAAAPTKARNASQTRmeqtsdssvSRSYAPLTQFHLVLVLDrPDPStamhgmDI 355  Kalmanozyma b...
EGN98979      197 TQQDDGKSEISSIAEKGp--------------------------------PAQSLWLQMFHFVIVLDlPDPS------SS 238  Serpula lacry...
XP_007842193  148 SRNDSAPRNDSSPSRSPSNEKSVAVp------------------------SNKCAWLHTFHLVMVLDlPDPS------SS 197  Moniliophthor...
EFJ03428      192 SSATNDDADPSDAHPAEHl-------------------------------GTKSAWLQSFHVVLVLDlPDPS------SS 234  Schizophyllum...
EPT01368      195 PKLAETSLTPDRVERHKRp-------------------------------LPDPSWLQTFHLVLVLDrPDPS------SS 237  Fomitopsis pi...
EFI27887      184 KEGEGSGKSKSPNPASALAPENGKEGvASSTTTTTAAVk-----------PKKPSWMQKFQLAFVLDlPDPS------SS 246  Coprinopsis c...
Q6FVA1        378 NKR-----VDDMYQYVVARLSVLLRYLQSKNDYVSEQCELILKEKEKVFKNskhykslslpseKGRYLYQRLLAKSSLAR 452  [Candida] gla...
GAC97587      356 SSW-----LQLFYDNIVFKMTAALFAEQQRVDYVGRETEKLLALRERCMDDg----------qAYSAYAAQCLGISSLAR 420  Pseudozyma hu...
KIS69018      356 SSW-----LQLFYDNIVFKMTAALFAEQSKSDYVGRETEKLLALRERCMDDg----------qAYAAYAAQCLGISSLAR 420  Ustilago mayd...
GAC76013      345 SSW-----LQLFYDNIVFKMTAALFAEQSKSDYVGRETEKLLALRERCMDDg----------qAYSAYAAQCLGISSLAR 409  Moesziomyces ...
EST05284      356 SSW-----LQLFYDNIIFKMTSALFAEQRESDYIGRETEKLLALRERCMDDg----------qAYAAYAAQCLGISSLAR 420  Kalmanozyma b...
EGN98979      239 ASGnvakyFDVIYEQIAFTVTAVLFQEQVLSNFVEAECDILVSLKDEYIDKg----------ePYSEFNAQALLRSSLAP 308  Serpula lacry...
XP_007842193  198 AAGnvskyFDVIYEQAAFIVSAVLFQEQVVSNYVEKECDQLGSLRDDCMKKg----------tSFSEFSSQALELSSLAS 267  Moniliophthor...
EFJ03428      235 NSGnvwkyFDIIYERIAFNLTAVLFREQVLSNFVEMECEQLMSIRESCIAKg----------eHFSTYMTQALAQTSIAP 304  Schizophyllum...
EPT01368      238 TSGtiwkyFDTIYEQIAFTTTAVLYQEQVLHNFVEDECDVLGALRDEYSRRg----------eQFADYLREALNMSSLAA 307  Fomitopsis pi...
EFI27887      247 ASGnvlkyFDIIYEQVVFTFTAVLFQEQVLSNFVEAECDVLIPMKESFAEQg----------qPYKEFVNQALQASSIAS 316  Coprinopsis c...
Q6FVA1        453 ALTECVEKIKKNEIACLEItDHRTVSLQIPIQNEFSilpqyklypvlkgSFLTSIQNnkfleksaniddnhhaksardtn 532  [Candida] gla...
GAC97587      421 CIRDLYKCISTSSDAFLTVnDSIEVHTQLPPILQDP-------------TNLHKMIDieteldsndpiflsgggfagrgk 487  Pseudozyma hu...
KIS69018      421 CIRDLHKSISISSDAFLTInDRIEVHLQLPPILQDP-------------SSLAKTVDieteldpndpiflsgggfeglgk 487  Ustilago mayd...
GAC76013      410 CIRDLHKSISTSSDAFLTInDRIEVHLQLPPILQDP-------------VNLPKTVDieteldpndpiflsgggfaglgk 476  Moesziomyces ...
EST05284      421 CIRDLYKSISTSSDAFLTInDNIEVHLQLPPILQDP-------------SNLLKTVDietdldkndpiflsgggfsglgk 487  Kalmanozyma b...
EGN98979      309 AMKTLYEAIQSSTMAYITI-HDLPLELQLP-------------------PYLDHLLHseeeydldfvdykedddes---- 364  Serpula lacry...
XP_007842193  268 AMKTLFEAIKASSIAYISL-NDLPLEIQLP-------------------PYLDLLLHndeeadfngfmvgdeedy----- 322  Moniliophthor...
EFJ03428      305 AMQVLFDAIKTSTIAYITI-HDLPMELQLP-------------------PYLDSLLKvesdddvdelqeqdaae------ 358  Schizophyllum...
EPT01368      308 SMKTLYESIKEKTIAQITI-HELPLELQLP-------------------PFLDSMLQaqdeleldavnprsedgl----- 362  Fomitopsis pi...
EFI27887      317 AMKCVYEAIKTRSIAYVTL-NNIPIELQLP-------------------PYLDTLLHndseldpdsierpddeeq----- 371  Coprinopsis c...
Q6FVA1        533 lisdhvntfsngqtkneifysknmenaltaqndyddddllLYSILLL-DDPDKIIADLD------------------NyS 593  [Candida] gla...
GAC97587      488 enaqedgt--ggtydrllamtpaqlsfeewcrttgpyllpWKTLLLLhDQVDD--GITPpvmassgqaglaspggggVqP 563  Pseudozyma hu...
KIS69018      488 egahqdgs--ggtykrrmamtpaqlsfeewcrttgpyllpWKTLLLLhDQVDEAPNRERaksdtcspaglaspgegaSqA 565  Ustilago mayd...
GAC76013      477 egadedgg--ggtydrllelaphqlsfeewcrttgpyllpWKTLLLLhDQPDEA-ARGRrtpgsasp---aghltpaEqA 550  Moesziomyces ...
EST05284      488 egqdedgg--ggthdrllglepnqlsfeewcrttgpyllpWKTLLLLhDHAD--PGRDRntagsssp---sgalspsGqA 560  Kalmanozyma b...
EGN98979      365 ----------------------rawgremsfgwrlpalapWKSLLLL-DGDQGLdpymn--------------lrgpHvR 407  Serpula lacry...
XP_007842193  323 ----------------------rawgpemsfgwrlpalvpWKSLLLL-DNIDDFdpfsd--------------lrgpHvS 365  Moniliophthor...
EFJ03428      359 -----------------------mwgphmsygwrletlapWKSILLL--EKDGFdpfas--------------lrgpHvS 399  Schizophyllum...
EPT01368      363 ----------------------lnpwgsmsvgwrlpalkpWKSLLRL-DDEDERGKNelyrr-----------lrapQlT 408  Fomitopsis pi...
EFI27887      372 ----------------------qnwgpelsfgwrlpalapWKSLLLL-DGSDELedpia-------------slrgpHvS 415  Coprinopsis c...
Q6FVA1        594 SNddi----ggvILKQLVK-VIQPNVPLLSYQYIinellaekplsssttankskqnkdnktntfysalLRSCALHLIYWR 668  [Candida] gla...
GAC97587      564 HEgdggferltrNFKSLFVpSLYNSLNFGNVADMfewn--------------------------lyddVYPMVRHLLYYK 617  Pseudozyma hu...
KIS69018      566 LEahgfd-qlarKFTSFFTpSLYNTPNFSQVADMlgwd--------------------------lyddVYPMVRHLIYYR 618  Ustilago mayd...
GAC76013      551 PEthgfe-qlarNFTSLFRpDLMHSLNFSEVADMlgwd--------------------------lyedVYPMVRHLIYYR 603  Moesziomyces ...
EST05284      561 PEthgfe-qltrNFTALFQpNLYHTLNFSDVADMlgwe--------------------------lyedIYPMVRHLIYYR 613  Kalmanozyma b...
EGN98979      408 PEert----laqGLIKFLE-TASVTLSLADMASLldwd--------------------------lenqIYPTVRWLVHHR 456  Serpula lacry...
XP_007842193  366 PDdrs----laeGLLKFLE-TANVTLSLTDLTSLmdwd--------------------------lesqVYPIVRWLVQHR 414  Moniliophthor...
EFJ03428      400 VNdrp----lvdGLIRFLE-VASITLSLADMSSLldwd--------------------------ldtqIYPVVRWLVEHR 448  Schizophyllum...
EPT01368      409 AEdne----laeQLVKFLE-IADVTLSLSDMASLldwd--------------------------letrIYPTVRWLVHHR 457  Fomitopsis pi...
EFI27887      416 VEdra----laeGLIRFLE-TASITLSLADMASLldwd--------------------------lesqVYPVVRWLVQHR 464  Coprinopsis c...
Q6FVA1        669 HARAILPISF--KNTYIVSPLSPVEadnsemikgnrkpsitdlnvtsnssskipVIYLNQQSFKLKF--PSLPSLPTFLN 744  [Candida] gla...
GAC97587      618 QARVIDVPRP--GHVYAISPLFDFA-----------------------------RLRPLSHVWAETF--PDLAPLPVFLS 664  Pseudozyma hu...
KIS69018      619 QARVIDVPRP--GHVYAISPLFDFA-----------------------------RLGSLSYNWAQTF--PDVAPLPVFLS 665  Ustilago mayd...
GAC76013      604 QARVIDIPRP--GHVYAISPLFDFG-----------------------------RLGALSRVWAHTF--PELAPLPVFLS 650  Moesziomyces ...
EST05284      614 QARVIDIPKP--GHVYAISPLFDFA-----------------------------RLGPLSHVWARSF--PDVAPLPVFLS 660  Kalmanozyma b...
EGN98979      457 RAKVVDIVHSglKTIFTLPPRFEAS------------------------------LSSLSIDFKREFphPSIPHLPTILS 506  Serpula lacry...
XP_007842193  415 RAKVVDIVHSglKTVFMLPPKFDYP------------------------------LSQLIKEFERDFseSNLPPLPQILS 464  Moniliophthor...
EFJ03428      449 RAKIVDVVHPglKTVFTLPPKFEQP------------------------------LSELTAEFEQEFtdPSVASLPEILS 498  Schizophyllum...
EPT01368      458 RAKVVDIVHPglRTIFTVPLKFTAP------------------------------MSALSADFDRRFaeHDVPPLPKILS 507  Fomitopsis pi...
EFI27887      465 RAKIVDIVNPglKTIFALPSKFPAS------------------------------LSTLSHQFNQQFnhPAIPSLPRILA 514  Coprinopsis c...
Q6FVA1        745 ILSLGK-----PKAFGNIIPSKEHKPIYMAALIWLIQKGYLTQLLTFVYIRVDKKIKM 797  [Candida] glabrata CBS 138
GAC97587      665 QLSSST-----SRTLSNLLPARHQKELALDVLIWLLRRDVVVKMHVRLRLVATESVMR 717  Pseudozyma hubeiensis SY62
KIS69018      666 QLSSST-----SRTLSNLFPARHQRELALEVLIWLLRHEVVVKMHIRLRLIATESVKR 718  Ustilago maydis 521
GAC76013      651 QLSSS------SRALSALFPGRHQRELALEVLIWLLRRDVVVKMHIRLRLFATEAVKR 702  Moesziomyces antarcticus T-34
EST05284      661 QLSSS------SRAFYALFPARHQRELALDVLIWLLRREVVVKMHIRLRLIATESVKR 712  Kalmanozyma brasiliensis GHG001
EGN98979      507 NVSTATskqsdNHFFATVVQSKELIPLYHDVVLWMLKHELLLTLHLRIRIVATSELKK 564  Serpula lacrymans var. lacrymans S7.3
XP_007842193  465 AISTSSanqsgNHFFASVVQSKDMIPTYHEVVVWMLKRDMLTTLHLRIRIVATAQLKA 522  Moniliophthora roreri MCA 2997
EFJ03428      499 LISTAPskqsdNHFYATVVQSRDLIPIYHDVVLWMLKRGLLIRLSLRIRIVATRELKE 556  Schizophyllum commune H4-8
EPT01368      508 MVSMSIhqqsaNHFYGTVVGSKERIPLYQDVVVWMLKRDLLLTLHLRIRIVATEELKH 565  Fomitopsis pinicola FP-58527 SS1
EFI27887      515 AISYSLaqqsnNHFFAAVVQRKELIPMYHDVVLWMLKRELLITLHLRIRIVVTPEIKQ 572  Coprinopsis cinerea okayama7#130
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