6MCP,4J1V


Conserved Protein Domain Family
Mob1_phocein

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pfam03637: Mob1_phocein 
Mob1/phocein family
Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. This family also includes phocein, a rat protein that by yeast two hybrid interacts with striatin.
Statistics
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PSSM-Id: 397617
Aligned: 140 rows
Threshold Bit Score: 137.667
Threshold Setting Gi: 121906080
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6MCP_B         4 EATLGSG-NLRQAVMLPEGEDLNEWIAVNTVDFFNQINMlYGT-IT-EfCTEASCPVMSAGPRYEYHWADG-TniKKPik 79 
A0BPC0        36 ELIRADSsNIKQIITPPPEVDIHVWQYEHLRQFILELNL-LVTqLKgL-CTAQTCPKMKATEDWLYLCAAHkK--AQE-- 109 Paramecium tetr...
XP_011406147  41 QLIRKDYkDVEAILDPPPVQDEASWKYEHLRQFCNELNS-LTVcLLeE-CDPLVCKQMTATEQWIFLCAAHrQ--PKE-- 114 Amphimedon quee...
XP_026644637 363 QNIRADCsNIDKILEPPEGQDEGVWKYEHLRQFCLELNG-LAVkLQsE-CHPDTCTQMTATEQWIFLCAAHkT--PKE-- 436 prairie vole
XP_002599458  46 QNIRQDHnNIDKILEPPEGQDEGVWKYEHLRQFCLELNG-LAVkLQtE-CNPETCTQMTATEQWIFLCAAHkT--PKE-- 119 Florida lancelet
XP_015790436  43 QSIKRDPsNIDEILKPPEGQDEGTWKYEHLRQFCMDLNK-LAVkLQtE-CLPSACVQMTATEQWIFLCAAHkT--PKE-- 116 two-spotted spi...
EFO15553      46 QCIHKDPsDVDTILKVPPGQEEGVWKYEHVRQFCMQLNG-LTLlLQdE-CKPDVCMQMTATEQWIFLCAAHkN--PKE-- 119 eye worm
P34349        45 QTIKANPaDVATILTPPLDQDEGVWKYEHLRQFCIELNG-LALlLQrE-CIPETCQQMTATEQWIFLCAAHkN--PNE-- 118 Caenorhabditis ...
EPB89947      46 QLIRLDYsDVQRIIELPENVDDEVWQYEHLRQVCLELSL-LVVaLEtD-CTKQHCPEMKA-DGWLYLCAAHpS--TQS-- 118 Mucor circinell...
EXX59452      71 SLIRANReNIDALVELPAGQDKETWQYEHLRQLCLELNY-LVIqLEaE-CTSQTCPEMKA-DDWQYLCAAHqA--PLN-- 143 Rhizophagus irr...
6MCP_B        80 CSAPKYIDYLMTWVQDQLDDETLFPSKIgVPFPKnFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQ------EEAHLNTS 153
A0BPC0       110 CSAIDYMIHNLDQSTSILTNIKTYPSRV-SINPQnATNNFAFIVRRLYRLFSHTYFNHKEIFEDFE------NEMFLCTR 182 Paramecium tetr...
XP_011406147 115 CSALDYTLHTLHGAASLLNSNKHFPSRV-SI-KEnSAQKLSSVARRIYRIFSHAYCHHRTLFNDFE------EKTYLCKR 186 Amphimedon quee...
XP_026644637 437 CPAIDYTRHTLDGAACLLNSNKYFPSRV-SI-KEsSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYE------NETFLCHR 508 prairie vole
XP_002599458 120 VRPDSHISSTFKNSLHLPKSVGALPSVI-SI-KEsSVAKLGSVCRRIYRIFSHAYYHHRNIFDEFE------NETCLCKR 191 Florida lancelet
XP_015790436 117 CPAIDYTRHTLDGASCLLNNTKYFPSRV-TM-KEsSVSKLGSVCRRVYRIFGHAYFHHRSIFDEFE------NSSHLCKR 188 two-spotted spi...
EFO15553     120 CSAIDYTRHTLDGAAALLNSNKYFPSRI-SI-KEsSIAKIGSVCRRIYRIFSHAYFHHPELFENFE------TETHLCRR 191 eye worm
P34349       119 CPAIDYTRHTLDGAATLLNSNKYFPSRV-NI-KEiSISKLGSVARRVYRIFSHAFFHHRKLFDEFE------NETHLCKR 190 Caenorhabditis ...
EPB89947     119 CPAIDYIIHTLDGATILLNNSKYFPSRI-SV-PEpSLKHFQSIARRLYRIFAHAYFHHREIYESFEasleflNETYLYAR 196 Mucor circinell...
EXX59452     144 CCAIDYIVHTLDGATTLLNSHKYFPSRI-SI-PEtSLKHYQSIARRLYRIFAHTWFHHREIFEAFE------NENMLYAR 215 Rhizophagus irr...
6MCP_B       154 fkhFIFFVQEFNLIDRRELA-PL 175
A0BPC0       183 ---FTEFALKFDLMSPKLIT-Ip 201 Paramecium tetraurelia
XP_011406147 187 ---FTRYVIKYDLMTTDNLIvPL 206 Amphimedon queenslandica
XP_026644637 509 ---FTKFVMKYNLMSKDNLIvPI 528 prairie vole
XP_002599458 192 ---FTVFVTKYNLMSKDNLIvPI 211 Florida lancelet
XP_015790436 189 ---FTIFVTKYNLMSKEHLIvPI 208 two-spotted spider mite
EFO15553     192 ---FTVFVKKYNLMANEHLIvPI 211 eye worm
P34349       191 ---FTTYVSKYNLMQQEHLIvPI 210 Caenorhabditis elegans
EPB89947     197 ---FLLLSQTYGLIPPSLVSipd 216 Mucor circinelloides f. circinelloides 1006PhL
EXX59452     216 ---FLKLSDRYELIAKNLLIiPY 235 Rhizophagus irregularis DAOM 197198w
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