2I7N,2I7P


Conserved Protein Domain Family
Fumble

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pfam03630: Fumble 
Fumble
Fumble is required for cell division in Drosophila. Mutants lacking fumble exhibit abnormalities in bipolar spindle organisation, chromosome segregation, and contractile ring formation. Analyses have demonstrated that encodes three protein isoforms, all of which contain a domain with high similarity to the pantothenate kinases of A. nidulans and mouse. A role of fumble in membrane synthesis has been proposed.
Statistics
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PSSM-Id: 397611
Aligned: 113 rows
Threshold Bit Score: 242.398
Threshold Setting Gi: 74950739
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2I7N_A          6 FGMDIGGTLVKL-----------------VYFEPkditaeeeqeevenlksirkylt----------------------- 45  
PDM81676       20 FSFDIGLRVIKV-----------------VYTSRihrhpaiv-------------------------------------- 44   Pristionchus ...
Q18580         23 ICFDACSKTVKI-----------------VYSSSvplshttlec------------------------------------ 49   Caenorhabditi...
XP_004996233   28 FAVDIGGSLAKL-----------------AYYAVhkrrtlsvkgdehrpsslhagsgvkpanagdqnggssaglengdda 90   Salpingoeca r...
A0DQ03         15 VCLDIGGTLTKL-----------------TFATKkgvslkcqtkk----------------------------------- 42   Paramecium te...
EGR28327       21 VGIDIGGTLAKL-----------------CFALQkgspvdfk-------------------------------------- 45   Ichthyophthir...
Q4U9L6        146 LSMDIGGTFVKIllnlpiknsenyhlfkdVYTSY---------------------------------------------- 179  Theileria ann...
XP_001913460   54 LSADMGGTMTKI-----------------VFWIPgdtdidlpkyvepeesvmsg-------------------------- 90   Entamoeba his...
Q384T6       1060 ISIDVGGTFAKL-----------------VYVQPpgdfkvphyvvkeaavlaegfn------------------------ 1098 Trypanosoma b...
Q4Q8Q6       1048 VTIDIGGTFAKI-----------------AFIMPptggafptfpsiiheasslsekl----------------------- 1087 Leishmania major
2I7N_A         46 -sntaygktgirdvhlelknltmCG---------------RkgnLHFIR--------FPSCA---------MHRFIQMGS 92  
PDM81676       45 ---------------nekfskegGT---------------R---LHCIH--------FPFTD---------LDKVCEYIA 74   Pristionchus ...
Q18580         50 ------------------------------trilskqsedR---IYCIQ--------VQYPD---------FPLILNFFG 79   Caenorhabditi...
XP_004996233   91 stsgtaedqkpdptsaaranslpCPpsssytvleeevevgR---LHLCY--------FKTTE---------LEECVRFIE 150  Salpingoeca r...
A0DQ03         43 -----------------------------elniinetedyE---IHFIS--------HPNS----------LDKLIENLE 72   Paramecium te...
EGR28327       46 ---------------hiehlairSYsd------------fD---VFFQT--------FQTND---------VESLIDFID 78   Ichthyophthir...
Q4U9L6        180 --------------------------------------------LHSIYisdrfselFGSTYkvnvenqrdLEDVLEFLH 215  Theileria ann...
XP_001913460   91 ---------------------fdlypdpvlkvtmnskgenE---LCFMK--------FPTSQ---------IPEFIHYAK 129  Entamoeba his...
Q384T6       1099 --vrmldlldnaegmkrllnddpFStv------------gT---LQFAK--------MSSKC---------IPDFMSYIV 1144 Trypanosoma b...
Q4Q8Q6       1088 -glrtfqffadeeaaeselrtrsHSlv------------gT---LRFLK--------IPSQQ---------VPRFTDYLA 1134 Leishmania major
2I7N_A         93 EKNFSSLHT------------------TL-----CATGGGAFKFEEDFRMIA-D--LQLHKLDELDCLIQGLLYVD-Svg 145 
PDM81676       75 QKVGNLSGKt----------------vQF-----TSTHKDSEECVRIIRDTL-R--VKMERVNDMRCHVKGTNFLL-S-- 127  Pristionchus ...
Q18580         80 ENCPLLKGT------------------TVd---fVVTASQNAEIEEVIRKVL-D--VELRHVDAFNGLVNGTSFLL-R-- 132  Caenorhabditi...
XP_004996233  151 DKMDSGDPC------------------VV-----RATGGGAHKYPALFASNN----MDVHKLDEMECLVRGSNYLL-K-- 200  Salpingoeca r...
A0DQ03         73 GIGFIVDGKsy--------------iqNF-----YITGGGSFKYYDQI-----SnyGKIIRINEFDALKFGFKLLDsI-- 126  Paramecium te...
EGR28327       79 QLNMNFITK------------------KF-----YITGGGAHKFEELFQKRL-K--VEIIKVQEFESLRMGFLLLDqL-- 130  Ichthyophthir...
Q4U9L6        216 SIFLSIKVRdrvlvfkyfplsdfengyNIegrclNFTGGGAYKYTEFLNSTFvKhnVKVNVMDEFSAIVEASKFL--T-- 291  Theileria ann...
XP_001913460  130 TSKLKEIYGign-------------lqIL-----NVTGGGAYKFANLLKDEM-D--LEVRQQDEMRCLVLGVNFLLlC-- 186  Entamoeba his...
Q384T6       1145 ESQMLSYYTkey-------------rnTL-----RVTGGGAFKYAALA-KKM-D--LNFSVMREMSAVVHGLGVVI-G-- 1199 Trypanosoma b...
Q4Q8Q6       1135 GSHAINNFKpqy-------------ttKV-----RATGGGAFKYASVARNVL-G--IEFDVVKEMDAVVKGLNLVL-R-- 1190 Leishmania major
2I7N_A        146 fNGKPECYYFE----Np--TNPELcQkkPyclDN---PYPMLLVNMGSGVSILAVYSKD-NYKRVTGTSLGGGTFLGLCC 215 
PDM81676      128 -NILDEVFVYDh--hNv-dCRYFFqTclN---SPhssVYPYVLVNVGTGMSIVRVNSES-DFEYIGGSHCGGGAFFGLAQ 199  Pristionchus ...
Q18580        133 -NIEAECFTYS----FdesQEYEFqTlnN---DS---MFPYLLINIRTGVSVVLVEGEN-QFKRLGGSSIGGGSFLGLTE 200  Caenorhabditi...
XP_004996233  201 -SVPDEAFTFNk---DttpQRQFFrP--S---SD---IFPYLLVNIGSGVSIIKVESDT-AFERVDGSALGGGTFWGLGS 267  Salpingoeca r...
A0DQ03        127 -KCKNTYFTFNngie---------ylqlT---AS---IYPFILVNIGSGVSILKFDNED-QFARISGTSLGGGMFLGLSH 189  Paramecium te...
EGR28327      131 -TPNDTVFTYSk-------QKGQQyIvkN---KS---LFPFLLVNVGSGVSIIKFLDEG-TIQRVNGTSIGGGFFLGLAH 195  Ichthyophthir...
Q4U9L6        292 -KMDKSAVRYDl-------IHRIPeVvsL---EP---VYPFIISNIGSGTFYLKVESEN-ENKHVFGTSISGGTSFGLVN 356  Theileria ann...
XP_001913460  187 -CQEKLCFRFv--------NKTKLyRevT---PE---IFPYLLVNVGSGVSILKVTAPE-KYERVSGSLIGGGTFWGLCC 250  Entamoeba his...
Q384T6       1200 -RAPETIFTVDpatgErhpHRLKSpPgeP---FS---PYPCLLVNIGSGISIIKCLGPDgSHVRIGGSPMGGATFWGLVR 1272 Trypanosoma b...
Q4Q8Q6       1191 -VAPESVFTVDpstgVhhpHQLVS-NgdG---FS---PFPYLLVNIGSGISLIKCTGADgSHVRVGGSPIGGATFWGLIR 1262 Leishmania major
2I7N_A        216 LLTGCETFEEALEMAA---KGDSTNVDKLVKDIY-GG---DYERFgLQGSAVASSFGNMMSKEkrds------------- 275 
PDM81676      200 LLIGSADMDELLVMAE---DGDHRKVDSLVSDIY-GM---KYEGLgLPPDLIAGSFGKCSNTKfadqvk----------- 261  Pristionchus ...
Q18580        201 LITGVSDIEEMMDRAL---QGSPDEFDIFIRDIY-GD---RASNFnMDPHLLAASFGRVTRGEtvrraen---------- 263  Caenorhabditi...
XP_004996233  268 LLTGAGGFDEILDLAQ---RGDCRNADMLVRDIY-GEt--TPQSLgLDPDLTASCFGKARKA------------------ 323  Salpingoeca r...
A0DQ03        190 LFTGINDFDELLKMTK---QGSNAHTDLLMDEVHlGF---QSPTRnKNEKHVAVSMGKLDQNIni--------------- 248  Paramecium te...
EGR28327      196 LLTGENNFNSLLDISN---KGDNQNLDLYVSDIF-GQ---SNAPKdIHGDALCVSMGKMTQKLkegq------------- 255  Ichthyophthir...
Q4U9L6        357 YLLPLKERRSFTKIFK---TGKYIYYDIIL--IK-G-------QIvLIHSLIIKARTTIRMRKfkkeeik---------- 413  Theileria ann...
XP_001913460  251 LLTNYKSFDEMLQAAQ---YGQHQNVDLYVKDIY-GR---CYDSVgLAADMMASSFGKIQKVPcgeak------------ 311  Entamoeba his...
Q384T6       1273 TMTAVTSWEEITETMRldgPGDNRNVDLLVGDIY-GYnakDLPPM-LSVDTVASTFGKLGTERfyesqgnvdrlyassse 1350 Trypanosoma b...
Q4Q8Q6       1263 TMTNLTSWEEVMEIMRldgPGDNKNVDLLVGDIY-GYnakDLPAM-LSSETVASTFGKLGTERfydmkrnictahfaddd 1340 Leishmania major
2I7N_A        276 -----------------------------iskEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLL 326 
PDM81676      262 --------------------------ndpdyrKDCIRSLLLMISNSIGQVVSLVLNNEKTNRLFFNGFMVRNHPIIMRTL 315  Pristionchus ...
Q18580        264 --------------------------fdeqskNNAILSLLRMILYNVSQLAYMLSEISNVKRVFFNGFLVRNRPIVMKTL 317  Caenorhabditi...
XP_004996233  324 --------------------------------QDAAASLLQMVAFNIAQISCLNARLHNIRHIFFAGFFIQNQPTTMHMI 371  Salpingoeca r...
A0DQ03        249 ------------------------------nkSDLVKSLLYMTTYNISQIAFLHSKLHNIERVFFSGHFIRNHEETLQCI 298  Paramecium te...
EGR28327      256 ----------------------------dvnkQDIVKSLLLMTSFNLSQIAFNQAKLEGIQNIIFAGNFVRNHPDTMDCI 307  Ichthyophthir...
Q4U9L6        414 -------------------------tdcelypGELYKSLIDMVAYNKGCLGYVIAKANGVKRIIYNGNFICKN--TMDSI 466  Theileria ann...
XP_001913460  312 ---------------------------nhyseADIAQGLMMMVCGSIAHLGFELTKLHHINRIFYTGGFVAHNPVVWEAI 364  Entamoeba his...
Q384T6       1351 dlsgavssspdsnptlhdavaptlashgktseIDIVRSLLNMISSNVTQLAYLHSRVQDVHNIFFAGGFVRNNPIVWSHI 1430 Trypanosoma b...
Q4Q8Q6       1341 aageils-pkgskspsviselpvrngtkaasaIDIVRSLLNMISSNVTQLAYLHARLHGVPNIFFAGGFVRDNAMIWSLI 1419 Leishmania major
2I7N_A        327 ----AYAMDFWSKGQ-----LKALFLEHEGYFGAVGA 354 
PDM81676      316 ----SYAINFWSKGA-----LQAHFLRHEAFNAAIGA 343  Pristionchus pacificus
Q18580        318 ----SFACNYWSSGK-----LRAYFLRHENYTTGLGA 345  Caenorhabditis elegans
XP_004996233  372 ----TQAVAYWGRGD-----ISALFLRHEGYVGAVGS 399  Salpingoeca rosetta
A0DQ03        299 ----NEAFSYFSKLDqq--nRHPYFIKHDGFIGSLGS 329  Paramecium tetraurelia
EGR28327      308 ----DHAIDYFNQAQskqnqNQAFFVKHDGFIGALGS 340  Ichthyophthirius multifiliis
Q4U9L6        467 vagfAFTSDVYRDKS-----IELCFPLHGPYIAALGS 498  Theileria annulata
XP_001913460  365 ----TTMLTTWSSGS-----VDANFLEYDGYFGSIGA 392  Entamoeba histolytica HM-1:IMSS
Q384T6       1431 ----SSFMAYWSKGE-----CHAHFLGHDSHLGALGA 1458 Trypanosoma brucei
Q4Q8Q6       1420 ----STTMKYWSSGE-----CHAHFLEHDGYLGALGC 1447 Leishmania major
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