Conserved Protein Domain Family
SLAC1

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pfam03595: SLAC1 
Voltage-dependent anion channel
This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.
Statistics
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PSSM-Id: 397585
Aligned: 450 rows
Threshold Bit Score: 52.2349
Threshold Setting Gi: 530560011
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7S1K0                 120 GCGLSRFTWPTSLGLLS--LILfllpppy------rfhglttLTTALFI-TDVVLFI-----LFS-LLVLCCALIhskcc 184 Neuro...
KuoIPMB:SSYRP_v1c05470  14 krPLALSGAALGTATMG--NAWgmfnetd-------lvfsfglSWLKYItISFAMLV-------ViLMLFKYFFA----- 72  Spiro...
KuoIPMB:SAPIS_v1c06630  14 KLPLSLAGTALGTATMG--NAWglfnnpi--------gfafdgSFVKYItISISLLL-------IiLMLIRYIIH----- 71  Spiro...
Q8EWI6                  18 HLPIAYTGLSLGFGGIG--NCLsllfnnf-------nnsnfnaSWISYItIFLVIFI-------LlVITIRNCCH----- 76  Mycop...
WP_016341216            10 YIPFSLLSISLGLLTLG--NGWnafgnf----------fslstKWITYLtFALSLFI-------FlLLTIKWIIN----- 65  Spiro...
BAH69882                 9 KVPLGLGGLALGISGLA--GAYngafnef--------knssngKLINNVsIGIQAFWmliafALAfIVCLRFI------- 71  Mycop...
Q7NB26                  19 QVPLALSGLTLGTIGLG--FSWeallthfkqvssdpetyktatLVVLFMlMLLSLLY-------GtIVAIKYL------- 82  Mycop...
EQB69328                10 mFGSEWFGMAISTLALSqiYILsygetgn--------vwynyiAEAFSI-TGIILFL-----VILvVWIIRGL------- 68  Therm...
Q6L253                   8 fFGSEWFGMAIATLAVAqtFFLasrymen--------itlkytGEIFFY-LGIIIFL-----VIFiLWTIRGL------- 66  Picro...
RogerUC:Ahos_1887        2 kLGSEWFPVVIGTFALSlvSWMnsilfk--------lqvlfdVGKVIYF-LALAIFA-----IIFsGWISRIMTN----- 62  Acidi...
Q7S1K0                 185 trPRQPCREL--TS----NAaKLGSLAYW------------------------PMAw-LTLV-------AFAVFlagygd 226 Neuro...
KuoIPMB:SSYRP_v1c05470  73 --PKDFIYDF--KH----PT-LSNFIPTI------------------------LMTc-FVISgfygqvnLPMVQ------ 112 Spiro...
KuoIPMB:SAPIS_v1c06630  72 --PVDLINDF--KS----PV-SSNFIPTI------------------------FMAl-FVISgffgvvnCNWIQ------ 111 Spiro...
Q8EWI6                  77 --PKLLKWELkeQM-------MVSLLPTY------------------------CMSf-MLVAgfiasfdSYMYSss---- 118 Mycop...
WP_016341216            66 --FKSVKQEF--QNnlndAA-IIGFLPIT------------------------VLAisKFIL------------------ 98  Spiro...
BAH69882                72 ----KARHVF--NKeakaPN-TAAFIPTL------------------------LMTf-ISIFtfiasilNTYLE------ 113 Mycop...
Q7NB26                  83 ----TNRKQF--VGylrtPNqAGLVFPFFmalglfgnflgylnvnylqtnfafSVVinIIVV------------------ 138 Mycop...
EQB69328                69 ----AIRDK---VFthwnNLtRLSFVA--------------------------LIPiiGFVAnyqliyfFGLSG------ 109 Therm...
Q6L253                  67 ----TIHDK---KWshwnNLtRLSFIA--------------------------LVPiiLFVInhitielYGINE------ 107 Picro...
RogerUC:Ahos_1887       63 -----WRED---ME----NLnRISFTA--------------------------FLGviLFIAgfffmtyVEINY------ 98  Acidi...
Q7S1K0                 227 qramagLrsgegignavsdgggggkkelrrRVltmIAYVMWW--------V-GVVWMTGT-----MVFVMG-VLagvvgg 291 Neuro...
KuoIPMB:SSYRP_v1c05470 113 --------------------------------------LIIW--------LsCISLHLIYiicftIYHVIHf-------- 138 Spiro...
KuoIPMB:SAPIS_v1c06630 112 --------------------------------------IVIW--------LvCVFLHLIYivsflIYHLVRf-------- 137 Spiro...
Q8EWI6                 119 ----------------------------------qIIGSILL--------IiAVGFHFVIlg-yfIFSVYK--------- 146 Mycop...
WP_016341216            99 ------Tkqdld--------------nlntGWiyyLGITIWW--------I-GLILAFSFfivwfFLHF----------- 138 Spiro...
BAH69882               114 -----------------------------------ASEAKKWlyiplvfsFiAFILQIAYlitfiVLIIVQ--------- 149 Mycop...
Q7NB26                 139 --------------------------------------------------F-STLCHVLCliyfvNVVLAK--------- 158 Mycop...
EQB69328               110 -------------------------------WsadLSILNFY--------G-EYLFALII-----GVLLGYrLY------ 138 Therm...
Q6L253                 108 -------------------------------LmarLSLYNYF--------F-SYFLALIL-----GVLLGYrIY------ 136 Picro...
RogerUC:Ahos_1887       99 -------------------------------EiayALLVLYF--------L-SYSIVFLV-----NVYLGYkLF------ 127 Acidi...
Q7S1K0                 292 qserwvlrkglnvrgeEeDEv-RVVLP--GCMLTSAFGMGLLALVG--GLLVSvlvrLGTLSVgma--tpVLVLSFCVEG 364 Neuro...
KuoIPMB:SSYRP_v1c05470 139 ---------------------sWKNYL--ASWFVPPIGIVVACVMS--KGV--------GANIslefsqgIHQLSQFCWY 185 Spiro...
KuoIPMB:SAPIS_v1c06630 138 ---------------------kFNNYM--ASWFIPPIGIVVACVMS--NNL--------GSFLggdfaavINLISKSCWY 184 Spiro...
Q8EWI6                 147 ------------------HNfkIKNDLvyGSYYVPPIGLIVACTVAnnFSLi------------------PNEFFQFIWY 190 Mycop...
WP_016341216           139 ------------------KNfkLVNAT--GSWYIPTIGIIICSTFElkyl-----------------gpgYLVFLQVLWY 181 Spiro...
BAH69882               150 ------------------HDfkYDEAF--ASWFIPTVGFVILTFGAnnyq-----------------niiPLLFYQILWF 192 Mycop...
Q7NB26                 159 ------------------HDleKDEVY--TSWNMPLVGLGISCSFY--PNLgln-------------neyYLAYYQILWL 203 Mycop...
EQB69328               139 ----------------T-KEinPREMN--YAIVIPPLAIGTSVFLA--TPL----------MKyfggfeaQSMYFLVLMG 187 Therm...
Q6L253                 137 ----------------T-KEinRNEIN--YAIIIPPLSIGTSIFLA--TPL----------IGyyhgtiaESIYFLVLMG 185 Picro...
RogerUC:Ahos_1887      128 ----------------T-KGvrQNEIS--YALLVPAIALSANVILS--APLLP----PSFPFIsty--fvKIVYFIMLFS 180 Acidi...
Q7S1K0                 365 VALFTTLCLYAVLQ-------QE-MIQVe-GWASVHLIKLSFWMMGSASV-------CAAAVqmLGRAVeDVsailgddd 428 Neuro...
KuoIPMB:SSYRP_v1c05470 186 LGLGYYVVMLPLMI-------YKySFTT---HLEHNNLPAYGIMAAPPNL-------LLAGY--LSTFSyTQ-------- 238 Spiro...
KuoIPMB:SAPIS_v1c06630 185 IGLAFYVIMLPPMM-------YKyLFTN---HLKEKKLQTFGVMAAPPNL-------LLAGY--LTTFSnQD-------- 237 Spiro...
Q8EWI6                 191 FGFISYVLMFLFVT-------YFmLFKN---KPEESRYASIAVWFAPINL-------VPSGF--IKVFMwIT-------- 243 Mycop...
WP_016341216           182 LNFAIFIGLTVLML-------ISyFKTK-----DHGMLRALFILLI--GLdvlmyitYDYTF--IKSGY----------- 234 Spiro...
BAH69882               193 IGLLFCFLIFILVA-------FKvAFVG---HKNHQDIPSLAIFCAPAMV-------LSFAF------------------ 237 Mycop...
Q7NB26                 204 ICSFLFVGSYFLFG-------YKqLFKG---FANKEDIGTMSIMASPPNL-------LLVGF------------------ 248 Mycop...
EQB69328               188 LGIFFFLYIFIGSLalsghvtTK----------VHDTLPTTMLPVGIASL-------IIINI------------------ 232 Therm...
Q6L253                 186 LGIFFFLYIFIGSValsghvsNK----------SGSSLPTAMLPVGVSSL-------IIINL------------------ 230 Picro...
RogerUC:Ahos_1887      181 VGITFFQVIFIGSI----------AFLShiI--YKESSATIMIPVGAASV-------LAINVlvfpsy------------ 229 Acidi...
Q7S1K0                 429 tqvgassgnffdtpataqvaHV---VCTLla----------------------llLL-GLAALWLIVSLVAFVsfaihrr 482 Neuro...
KuoIPMB:SSYRP_v1c05470 239 -------------------------IASQyn----------------------lvIF-GLAPLAIFFTICVYIsmfktfq 270 Spiro...
KuoIPMB:SAPIS_v1c06630 238 -------------------------INNHky----------------------ffVY-ILCALAILFTLIVYLslfkvsr 269 Spiro...
Q8EWI6                 244 --------------------ESnysQTYIft----------------------lfILtTIWGFVFSSLLYIYIfrtf-kn 280 Mycop...
WP_016341216           235 --------------------NEnywMVIIig----------------------vfAIaASFAFYFLIvkdf-------lt 265 Spiro...
BAH69882               238 -------------------------LTLFdpknpnanilnnyvilytftgilflfILvGWAAYFYSLAISIKSk------ 286 Mycop...
Q7NB26                 249 -------------------------LKIFnpavhqhallinfsvtafniltysfiFFsMVGLFIYFLTAIKLLvm----- 298 Mycop...
EQB69328               233 -------------------------FTISgfkvignisls-----astvelvsilLW-GFEVWNFLVVLLLILtkp---- 277 Therm...
Q6L253                 231 -------------------------ISINsfgavidhlpf----siytvefvsilLW-GFEVWNFLVMMIIVFrke---- 276 Picro...
RogerUC:Ahos_1887      230 --------------nylhlfYFppkFALTla----------------------imLW-GFEIWNSLVALIIAVkhi---k 269 Acidi...
Q7S1K0                 483 lsWKGQCSDTVIPVAALALSTV------QFKsd-------------lnSSF--F-GIVTC---V------LVVAAAASFL 531 Neuro...
KuoIPMB:SSYRP_v1c05470 271 kkFMPLFACYTFPLAIGMVAMV------KL------------------STWi-I---------TifpnasQLAAIIKVWA 316 Spiro...
KuoIPMB:SAPIS_v1c06630 270 ekFSPLLGCYTFPLAIGMISMI------KM------------------SEFl-F---------MslgadnIYVISFKIWA 315 Spiro...
Q8EWI6                 281 ykFNPVFCSMTFPSAIGATSMVltagqyRKLatnildtnsisyqffnsGQW--IfGIAGF---I------FSIVSFLIIS 349 Mycop...
WP_016341216           266 kqFNPKLTSYAFPLAISAIGKI------TYgqslgai----snpeyadTIIl-IfQYWSI----------CEIILTTIIF 324 Spiro...
BAH69882               287 -kFYFTWACFTFPIEISSTALF------KY------------------AQVv-FtKDLNV---YvhfafiILAILFLIFA 337 Mycop...
Q7NB26                 299 rnFGFAWTAFTFSGTINARALLdtvnqgGL------------------PDSi-YyILLGIsigL------ISVVSLIVSL 353 Mycop...
EQB69328               278 srGTLSVWAYGFPLGLFATSTM------KIfd---------------fTSYsaLlWAFIG----------ISAALNILWV 326 Therm...
Q6L253                 277 tfGYLSVWAYGFPLGLFATSTI------KLee---------------vTKIviLgNIFIF----------IWVALVLLWF 325 Picro...
RogerUC:Ahos_1887      270 dkPSLTSWAYVFPLAISSFSDF------MLyq---------------eTSLp-VfEATEV---A------FSLAIVLLYA 318 Acidi...
Q7S1K0                 532 INLV--LC 537 Neurospora crassa
KuoIPMB:SSYRP_v1c05470 317 LIATitGT 324 Spiroplasma syrphidicola EA-1
KuoIPMB:SAPIS_v1c06630 316 LIETiiGT 323 Spiroplasma apis B31
Q8EWI6                 350 YILVrmfi 357 Mycoplasma penetrans
WP_016341216           325 LYLIgnlt 332 Spiroplasma syrphidicola
BAH69882               338 TVII--NY 343 Mycoplasma fermentans PG18
Q7NB26                 354 LTIKtffn 361 Mycoplasma gallisepticum
EQB69328               327 YAWI--NT 332 Thermoplasmatales archaeon Gpl
Q6L253                 326 YGIL--NT 331 Picrophilus torridus
RogerUC:Ahos_1887      319 YSLR--NT 324 Acidianus hospitalis W1
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