Conserved Protein Domain Family
Paxillin

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pfam03535: Paxillin 
Paxillin family
Paxillin is a multi-domain protein that localizes in cultured cells primarily to sites of cell adhesion to the extracellular matrix (ECM) called focal adhesions. The family here represents the N-terminal regions with the proline-rich part as well as the Paxillin part. Focal adhesions form a structural link between the ECM and the actin cytoskeleton and are also important sites of signal transduction; their components propagate signals arising from the activation of integrins following their engagement with ECM proteins, such as fibronectin, collagen and laminin. Importantly, focal adhesion proteins including paxillin also serve as a point of convergence for signals resulting from stimulation of various classes of growth factor receptor.
Statistics
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PSSM-Id: 397550
Aligned: 15 rows
Threshold Bit Score: 180.833
Threshold Setting Gi: 47205346
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003430178   31 VPPPPSSEALNGTVL-DPPDQWQPSSSRflhqqppppRS-Q--------SPV--------Y-SSGAKTSSasvppdglds 91   platypus
XP_003445713   49 VPPPPSAEALNGSLR-DQPDSHHSSQ-----------QS-L--------GSA--------QkSSWSRDSS---------- 89   Nile tilapia
XP_023180566   49 sSPPERS--LNGVdd---------------------sES-F--------SSA--------QkSQWSRESS---------- 78   southern plat...
XP_016852084   78 VPPPPSNEALNGTVN-DPLDQWQPSIPKnih---qqpQS-Q--------SPV--------Y-SSSASGSRec-------- 127  green anole
XP_019476715   82 VPPPPSSEALNGTVI-DPLDQWQPSVSRyah---qqpQS-Q--------SPI--------Y-SSSAKSSSasvpr---dg 136  turkey
NP_598676      49 VPPPPSSEALNGTVL-DPLDQWQPSGSRyah---qqpPS-P--------LPV--------Y-SSSAKNSSasntq---dg 103  house mouse
XP_007490399   49 VPPPPSSEALNGTVL-DPPDQWQSGGPRyih---qqsQP-Q--------SPV--------F-GSGAKNPGvpvsr---ds 103  gray short-ta...
CAG01877        1 --------dalladlesttshiskrplflsdeaaysfpS-F--------SPA--------QkSPWSRESS---------- 45   spotted green...
XP_020561825   49 LPPPPSAEALNGTLT-DRPNSHLSCQ------------LsV--------GSA--------QkSLWSRDSS---------- 89   Japanese medaka
CAF93475       45 VPPPPSADALNGSSRvEASHSHHSSQQVretsktrdaHV-KplrrahgpGTAsalrrptlKkTTFTGVAS---------- 113  spotted green...
XP_003430178   92 fgpPCSQ-AGEEEH-------VYSFPNKQKSAEPSP--TMMSSSLGSNLSELDRLLLELNAVQHNAPgGFLADEASQ--S 159  platypus
XP_003445713   90 ---SSPLsHIEEDH-------VYSFPNKQKTSDSST--TAMTSALGSNLSELDRLLLELNAVQQSSP-SFPT--TEEa-A 153  Nile tilapia
XP_023180566   79 ---SPNQpSGEEDH-------VYSFPNKQKTSESSSspAAMNSSLGSNLSELDRLLLELNAVQQSTP-AFPT----Ev-A 142  southern plat...
XP_016852084  128 -viSPPR-ASEEEH-------VYSFPNKQKSAEPSP--TLMSSSLGNNLSELDRLLLELNAVQHNPPsSYPADEAAR--T 194  green anole
XP_019476715  137 lssPSPR-ASEEEH-------VYSFPNKQKSAEPSP--TMTSTSLGSNLSELDRLLLELNAVQHNPPsGFPADEVSR--S 204  turkey
NP_598676     104 vgsLCSR-AGEEEH-------VYSFPNKQKSAEPSP--TVMSSSLGSNLSELDRLLLELNAVQHSPP-GFPADEAES--S 170  house mouse
XP_007490399  104 lgsPCPRgAGEEEH-------VYSFPNKQKSAEPSP--T-MSSSLGSNLSELDRLLLELNAVQH-PTsGFLADDANQ--S 170  gray short-ta...
CAG01877       46 ---SPSQpVCEEDH-------VYSFPNKQKSSDSSA--AAMNSALGSNLSELDRLLLELNAVQQSAP-AFPTE--EEa-A 109  spotted green...
XP_020561825   90 ---SSPLsHAEEDH-------VYSFPNKHKTSDSSS--VAMTSGLGSNLSELDRLLLELNAVQKSSP-SFPT---TEeaA 153  Japanese medaka
CAF93475      114 ---STRLlPRRRRLqppsvalFSSFPNKQKPSDSSS--AAMTSALGSNLSDLDRLLLELIAVQQSSP-SFPT--TEEa-A 184  spotted green...
XP_003430178  160 PPLPGAPGSHYGIPENSSPPGDQTAPPAKEk-PKRNG-SRGLEDVRPSVETLLDELESSVPSPVPAITMSQGEVSSPQPV 237  platypus
XP_003445713  154 PPLPSCSITHY---ENGGTPDILVSPPPQEk-PKRNG--R-MEDARPTVESLLDELEGSVPSP--SPSTRHSDL-----D 219  Nile tilapia
XP_023180566  143 PPLPASSTIRH-IQENGLSAPGRIPPPTLEk-PKHVVaARGIQDARPSVESLLDELESSVPTPIPTPLVVSDD---GQAE 217  southern plat...
XP_016852084  195 PSLPSGAGSHYSALENATSLNTQPTAPAKEk-PKRNG-GHGIEEVCPSVESLLDELESSVPSPVPAITVNQGEMSSPQRV 272  green anole
XP_019476715  205 PSLPNVTGPHYVVPESSSSAGGKAAPPTKEk-PKRNG-GRGIEDVRPSVESLLDELESSVPSPVPAITVSQGEVSSPQRV 282  turkey
NP_598676     171 PPLPGALSPLYGIPENNTPLGGKAGPLVKEk-PKRNG-GRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSPQRV 248  house mouse
XP_007490399  171 PPVPGGLSPQYGIPENNSPLGGKATPSSERrsPSGNG-ARGLEDLRPSVESLLDELESSVPSPVPAITVNQGEMNHPQRV 249  gray short-ta...
CAG01877      110 PPLPSSSIIHQ-IHENGVSPAGRTAPATLEk-PKRGGaGRVMEDARPSVESLLDELESSVPSPIPTPLAAPDEQADAPEE 187  spotted green...
XP_020561825  154 PPLPSCSIIHF---ENGGTPEILLSPPSQEk-SIRNG-AK-LEESRPTVKSLLDELEGPVPSP--SPPARHSDL-----D 220  Japanese medaka
CAF93475      185 PPLPSCSITHY---ENGGGPDVRVTPPPQEk-PVRNG-TR-TDEARPSVESLLDELESSVPSP--SPPGRHGDA-----D 251  spotted green...
XP_003430178  238 PSSQQ 242  platypus
XP_003445713  220 TSSQQ 224  Nile tilapia
XP_023180566  218 TLSQQ 222  southern platyfish
XP_016852084  273 TASQQ 277  green anole
XP_019476715  283 TASQQ 287  turkey
NP_598676     249 TSSQQ 253  house mouse
XP_007490399  250 TSSQQ 254  gray short-tailed opossum
CAG01877      188 TPTQQ 192  spotted green pufferfish
XP_020561825  221 TPSQQ 225  Japanese medaka
CAF93475      252 TPAQQ 256  spotted green pufferfish
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