Conserved Protein Domain Family
KCNQ_channel

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pfam03520: KCNQ_channel 
KCNQ voltage-gated potassium channel
This family matches to the C-terminal tail of KCNQ type potassium channels.
Statistics
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PSSM-Id: 397540
Aligned: 13 rows
Threshold Bit Score: 339.803
Threshold Setting Gi: 908526062
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005457717 427 LTGNADSIEE-SPSKEPKPAGFTNRER-FRTAFRMKantLRQSSEd--A-GGVADPALEE-RGFPPDILLEEMIPTLKLV 500  Nile tilapia
XP_016851815 408 SPSTENINEAaSPTKVQKSWSFNDRTR-FRASLRLK---PRIPVE---A-DGPVEESSEE-KAYQCDLTFEDIMPAVKTL 478  green anole
Q0P4Q9       368 SPGTEPAAETpSPTKVQKSWSFNDRTR-FRASLRLK---SRPQAD-----EGPGDDINDE-KRLPNDLTMEDVMPTIKTL 437  tropical clawe...
Q9JK97       465 SPSSEQVGEAsSPSKVQKSWSFNDRTR-FRASLRLK---PRCSAE-----EGPSEEVAEE-KSYQCELTVDDVMPAVKTV 534  house mouse
XP_015203979 482 SPSSESVPEAtSPGRVQKSWSFNDRTR-FRTSLRLK---PRPSAD---V-EAPAEDGAED-KAPHCDVTMEEVIPAVKTL 552  spotted gar
O43525       446 TPLNVDAIEE-SPSKEPKPVGLNNKER-FRTAFRMKayaFWQSSEd--A--GTGDPMAED-RGYGNDFPIEDMIPTLKAA 518  human
XP_003462849 466 SPSADQSLED-SPSKVPKSWSFGDRSR-ARQAFRIKgaaSRQNSEe--A-SLPGEDVVEDnKSCNCEFVTEDLTPGLKVS 540  domestic guine...
XP_013129194 448 PGGADDGAEA-SPSKVTKSSSFTDKNRgAKNAFKARgsiSRKNSEe--A-SLPGEEIGDD-KSCHCEFLTQELPPGLKVA 522  Nile tilapia
EAW48782     272 SPSTDITAEG-SPTKVQKSWSFNDRTR-FRPSLRLKssqPKPVIDa-dT-ALGTDDVYDE-KGCQCDVSVEDLTPPLKTV 346  human
XP_697081    432 SPGAEISTDGsSPAKVQKSWSFNDRTR-FRPSLRLKs-qSRSTPEg-eA-NVTVDEAFDE-KGCHCDMSVEDLPSALKTV 506  zebrafish
XP_022530323 422 SPGAEINTEGsSPAKVQKSWSFNDRTR-FRPSLRLKs-qSRSTTDaesN-VGAGEEGFDD-KGCHCEISAEDLLPAVKTV 497  Mexican tetra
XP_029690384 448 SPGAEEGVEA-SPYKVAKSWSFTDKNRgTKNSFKARgstSRQNSEe--A-SLPGEEMGDD-KSCHCEFLTQELPSSLKVT 522  torafugu
XP_014344588 405 SPSTENVNETiSPTKVQKSWSFNDRTR-FRTSLKLK---PRLPIEg-hAaDGHGEDSNDE-KAYHCDLTVEDIMPAVKTL 478  coelacanth
XP_005457717 501 IRAVRIMQFLLNKKRFKETLRPYDVKDVIEQYSAGHLDMLCRIKYLQTRIDMILAPGPPLTPKHKKtQKTPftyppnqs- 579  Nile tilapia
XP_016851815 479 IRAVRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQIVGRGAIAIDKKVR-EKGEk-------- 549  green anole
Q0P4Q9       438 IRAFRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQGRVDQIIGRGPVPVEKKPR-DKGEkv------- 509  tropical clawe...
Q9JK97       535 IRSVRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQARVDQIVGRGP--GDRKTR-EKGDk-------- 603  house mouse
XP_015203979 553 IRAVRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGAIQPDRKVRsEKGEk-------- 624  spotted gar
O43525       519 IRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKsQKGSaftfpsqqs 598  human
XP_003462849 541 IRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAITDKDR--TKGPa-------- 610  domestic guine...
XP_013129194 523 IRAICIMSFLVSKRRFKESLRPYDVMDVIEQYSAGHLDMLSRIKNLQTRVDQIVGKGP----------KG---------- 582  Nile tilapia
EAW48782     347 IRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSR-EKITa-------- 417  human
XP_697081    507 IRAVRIMKFHVAKKKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGRGQMPVDKKVR-EKLLs-------- 577  zebrafish
XP_022530323 498 IRAVRIMKFHVAKKKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQVPVDKKLR-EKLMs-------- 568  Mexican tetra
XP_029690384 523 IRAICIMKFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLCRIKNLQTRIDMIVGPPPPSTPRHKKsTEGPrvdqiv--- 599  torafugu
XP_014344588 479 IRSVRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQIRVDQIIGRGPIPNDKKTR-EKGEk-------- 549  coelacanth
XP_005457717 580 prhesyiaKATSMPDAEDQSMMGRFVRVERQVEDMEKKLDFLVDMHIQHTEHL 632  Nile tilapia
XP_016851815 550 --------SSLEMELVDELSMLGRVVKVEKQVQSIEHKLDLLLGVYSQCLRKG 594  green anole
Q0P4Q9       510 ------stMGPEVEAADELSMMGRVVKVERQVQSIEDKLDILLGFYSQCIRKG 556  tropical clawed frog
Q9JK97       604 --------GPSDTEAVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSG 648  house mouse
XP_015203979 625 --------TPPELDPLDELSMMGRVVKVEKQVQSIEHKLDLLLNFYTQCLKKG 669  spotted gar
O43525       599 prnepyvaRP-STSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERL 650  human
XP_003462849 611 -----------EAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIP 652  domestic guinea pig
XP_013129194 583 -----------EGDAVEDQSMMGRLVKVEKQVVCMDRKLDFLVNVYVQRMGIP 624  Nile tilapia
EAW48782     418 -----------EHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKG 459  human
XP_697081    578 -----------DGDILEDVSMLGRVCKVERQVQSIESKLDSLLDIYRQVLQKG 619  zebrafish
XP_022530323 569 -----------EGDLLEDVSMLGRVCKVERQVQSIESKLDSLLDIYRQVLRKG 610  Mexican tetra
XP_029690384 600 -----gkspkaDGDPGDDLSMMGRLVKVEKQVLCMDRKLDFLVNVYVQRMGIT 647  torafugu
XP_014344588 550 --------VPPELDQMDELSMMGRVVKVEKQVQSIEQKLDLLLDVYSQCLRKG 594  coelacanth
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