4FXQ


Conserved Protein Domain Family
ADPrib_exo_Tox
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pfam03496: ADPrib_exo_Tox 
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ADP-ribosyltransferase exoenzyme
This is a family of bacterial and viral bi-glutamic acid ADP-ribosyltransferases, where, in Aeromonas salmonicida AexT, E403 is the catalytic residue and E401 contributes to the transfer of ADP-ribose to the target protein. In clostridial species it is actin that is being ADP-ribosylated; this result is lethal and dermonecrotic in infected mammals.
Links
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Statistics
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PSSM-Id: 397527
Aligned: 22 rows
Threshold Bit Score: 134.417
Threshold Setting Gi: 228861510
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4FXQ_A         236 AESWGVQTFKNWKENL-----------------------TISEKDIITGYTGSKYDPINEYL--RKYDgeiiPNIG-GDL 289 Bacillus cereus
YP_002854531   377 KNSWNAAKTKFLKRMIysfsgigagpmiditiardgskyTPSQKRGIREYCGSGYTDINNLLlgRYNPer-yDVMSeKEI 455 Escherichia v...
EEL03029       217 ALQWAKENLKGYAEKL-----------------------NADEKAEIDFYTTSNYSTINSYL--RDSEgs-kyQDK-EGL 269 Bacillus cere...
ABR68092       276 AHSWGMKIYEDWAKNL-----------------------TASQREALDGYARQDYKEINNYL--RNQGgs-----gnEKL 325 Bacillus thur...
AIA96500       266 GDSWGKKNYKEWSDSL-----------------------TNDQRKDLNDYGARGYTEINKYL--R-EGgt-----gnTEL 314 Bacillus thur...
EDT15235       261 GDLWGKENYSDWSNKL-----------------------TPNELADVNDYMRGGYTAINNYL--ISNGplnnPN---PEL 312 Clostridium p...
KEI06358       226 SEAWGEKNYGDYVSKL-----------------------SQEQLGALEGYLHSDYKAINSYL--RNNR-----VPNnDEL 275 Clostridium s...
Q977Y7         207 ANEWGSQYYDNWLKSL-----------------------NDSERNAIRQYTGNDYKKINNYL--RGVN----DSLD-GID 256 Clostridium a...
P12726         374 QNSWNAIKTKIIRRELrgyaltagwslhpivenkdsskyTPAQKRGIREYVGSGYVDINNALlgLYNPdertSILTaSDI 453 Escherichia v...
TMHRI:Sez_0628  46 TNRWRSQTAF-----------------------------TEAEKKMMYQYTHASASPINLAL--EQVMgdtsQLD--AQL 92  Streptococcus...

4FXQ_A         290 DKKskkalekienqIKNLDAALQKS-KITENLIVYRRVselqfgkkyed----ynlrqngiinEEKVMELESNFKGQTFI 364 Bacillus cereus
YP_002854531   456 ESA-----------INNLDSAFENGdRIPEGITVYRAQ-------------------------SMTAPIYEALVKNKVFY 499 Escherichia v...
EEL03029       270 KKR-----------IDLISSGLQKL-SLPTDIVVYRRTgtdtfkpdpn-----npilkfdfnnPKDIESFKKQYEGSLNE 332 Bacillus cere...
ABR68092       326 DAQ-----------IKNISDALGKK-PIPENITVYRWCgmpefg-------------yqisdpLPSLKDFEEQFLNTIKE 380 Bacillus thur...
AIA96500       315 EEK-----------IKNISDALEKN-PIPENITVYRYCgmaefg-------------ypiqpeAPSVQDFEEKFLDKIKE 369 Bacillus thur...
EDT15235       313 DSK-----------VNNIENALKLT-PIPSNLIVYRRSgpqefgltl-------tspeydfnkIENIDAFKEKWEGKVIT 373 Clostridium p...
KEI06358       276 NKK-----------IELISSALSVK-PIPETLIAYRRVdgipfdlpsdfs-fdkkengeiiadKQKLNEFIDKWTGKEIK 342 Clostridium s...
Q977Y7         257 PKI-----------IEDIKSGLKKA-SVPHDMKVYRGTdlnplr--------------nlidvGKDGSLDFSSLVGKTFK 310 Clostridium a...
P12726         454 EKA-----------IDNLDSAFKNGeRLPKGITLYRSQ-------------------------RMLPSIYEAMVKNRVFY 497 Escherichia v...
TMHRI:Sez_0628  93 QQS-----------VALLDSATHKL-TIPWNIIVYRYVyetfltelgiseeelaryyhdktfdPQILSAIK---PGARYT 157 Streptococcus...

4FXQ_A         365 QHNYMSTSLVQD-------PHQSYSNDryPILLEITIPEGVHGAYIAD--M----------------------------- 406 Bacillus cereus
YP_002854531   500 FRNFVSTSLTPIifgrfgiTHAGIGLLepEARNELTVDKNEEGITINPneIraykenpeyvkvqigwaidgahkvnvvyp 579 Escherichia v...
EEL03029       333 EKAFLSTSLVRDp-----dLYGSFMQK--RILMRITLPKGTHAGFLPAleL----------------------------- 376 Bacillus cere...
ABR68092       381 DKGYMSTSLSSE-------RLAAFGSR--KIILRLQVPKGSTGAYLSA--I----------------------------- 420 Bacillus thur...
AIA96500       370 EKGYMSTSLSSD--------ATSFGAR--KIILRLQIPKGSSGAYVAG--L----------------------------- 408 Bacillus thur...
EDT15235       374 YPNFISTSIGSV-------NMSAFAKR--KIILRINIPKDSPGAYLSA--I----------------------------- 413 Clostridium p...
KEI06358       343 NLSFSSTSLKST--------PLSFSKS--RFIFRLRLSEGTIGAFIYG--F----------------------------- 381 Clostridium s...
Q977Y7         311 DDGFMSTALVKE---------SSFDYM--NVSWEINVPKGTEAAYVSK--I----------------------------- 348 Clostridium a...
P12726         498 FRNFVSTSLYPNifg-twmTDSSIGVLpdEKRLSVSIDKTDEGLVNSSdnLvgigwvitga----------dkvnvvlpg 566 Escherichia v...
TMHRI:Sez_0628 158 KQGFMSTTAIKN---------AAMPHR--SVELRIRIPQGSQAAFVQP--Y----------------------------- 195 Streptococcus...

4FXQ_A         407 -SEY-PGQYEMLINRGYTFKYDKFSIVKptreeDKGKEYLKVNLSIYLG 453 Bacillus cereus
YP_002854531   580 gSLGiATEAEVILPRGLMVKVNKITDASnndgtTSNNTKLIQAEVMTTE 628 Escherichia virus RB14
EEL03029       377 -GTY-QGENEMLLDHGYQYKIDKIGTVEtelstGKRRTDVFVEATVLPK 423 Bacillus cereus BDRD-ST196
ABR68092       421 -GGF-ASEKEILLDKDSKYHIDKATEVI-----IKGVKRYVVDATLLTN 462 Bacillus thuringiensis
AIA96500       409 -DGFkPAEKEILIDKGSKYHIDKVTEVV-----VKGIRKLVVDATLLLK 451 Bacillus thuringiensis serovar tolworthi
EDT15235       414 -PGY-AGEYEVLLNHGSKFKINKVDSYK-----DGTVTKLILDAT-LIN 454 Clostridium perfringens E str. JGS1987
KEI06358       382 -SGF-QDEQEILLNKNSTFKIFRITPITsiinrVTKMTQVVIDAEVIQN 428 Clostridium sp. K25
Q977Y7         349 -SYF-PDEAELLLNHGQEMIIKEATVG------SDGKLNIVLD-LNLKR 388 Clostridium acetobutylicum
P12726         567 gSLApSNEMEVILPRGLMVKVNKITDASyndgtVKTNNKLIQAEVMTTE 615 Escherichia virus T4
TMHRI:Sez_0628 196 -SFY-PYEMELLFPRQCTLEI--IGANL-----SDDHTRLLIETR-LLP 234 Streptococcus equi subsp. zooepidemicus MGCS...
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