2P6Y,2H6L,3HTN


Conserved Protein Domain Family
DUF296

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pfam03479: DUF296 
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Domain of unknown function (DUF296)
This putative domain is found in proteins that contain AT-hook motifs pfam02178, which strongly suggests a DNA-binding function for the proteins as a whole. There are three highly conserved histidine residues, eg at 117, 119 and 133 in Reut_B5223, which should be a structurally conserved metal-binding unit, based on structural comparison with known metal-binding structures. The proteins should work as trimers.
Statistics
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PSSM-Id: 397515
Aligned: 360 rows
Threshold Bit Score: 54.8317
Threshold Setting Gi: 158333050
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2P6Y_A                 5 IALRLTRGXDLKQQIVQLVQQHrIHAGSIaSCVGCLSTLHirladsv----stlqvsAPFEILSLSGTLTYq----Hc-- 74  Vibrio ...
Q026M0                10 tVLVFDRGDEVVSTLTKFAKENrVAAAHF-TAIGAFSDAVigyfdlekkdylknqvnEQVEVVSLIGDIALd---kGepk 85  Candida...
WP_012871349          14 YAVIFDSGDEVFEGLTEFAREQgLTAAHF-TGVGAFSDVVlgffdldkkdyeqipieEQVEVLSLVGDIALdpvegGgpk 92  Sphaero...
Q1ASJ2                16 FALAFRPGDEVLRGITGFAGELgLDAAEV-TGLGAFSSATlgyfdlekrdyeeipvgEQAEVLTLVGNIASf---rGepr 91  Rubroba...
WP_012093592          15 FVVILAPEEAVVATLTRFVQKRdLTAASV-TAIGAFRRATlgffdlerqdyhrieldEQCEVLSLLGDCALge--eGspi 91  Ochroba...
Q9RD14                67 YVVVLDQGEDAVAELTAFARERsLGASQV-TAVGAFSQAVvgwfdrqakdyrhipvrEQCEVLSLIGDIAVad--dGpt- 142 Strepto...
jgi:Snov_0411         15 FALVLDPGEEAFAAIRDFAAKEgISAASV-TAIGAFSRATvgwfdfdtrdyrripveEQCEVLSALGDIARdd--dGkas 91  Starkey...
Q92X95                40 FILVLEEGDEAFSAISAFAAQAdIAGASV-TAIGAFSSATvgffriesrdyrkipvaEQSEVLSAIGDIARde--aGsps 116 Sinorhi...
goetting:OCA5_c30300  15 YAVVMAAGDEAMSCLEQFAREVgLSAASL-TAIGALRSAElayfdwetkrylpipveDQVEVASLIGDIAIgp--dGkpa 91  Oligotr...
CAL61860              14 YALILETGEEVVSQLQRFIKENdLAASRF-TAIGAFSSATlayfnwdqkdyekiavsEQVEVLSLIGDVAKq---dGesk 89  Hermini...
2P6Y_A                75 -hLHIAVADaqGRVWGGHLLeGNLiNTTAELXIHHYP 110 Vibrio cholerae
Q026M0                86 vhAHVVVGKrnGSAMGGHLLeAHV-RPTLELVLQDsg 121 Candidatus Solibacter usitatus Ellin6076
WP_012871349          93 vhAHVVVGKrdGTAYGGHLLgGHV-RPTLEVIVEEAP 128 Sphaerobacter thermophilus
Q1ASJ2                92 phLHAVLGRrdGSTVGGHLLeARV-RPILEVVITESP 127 Rubrobacter xylanophilus DSM 9941
WP_012093592          92 lhLHVVLGMrnGEAKGGHLIeALV-RPTLEVMIKENT 127 Ochrobactrum
Q9RD14               143 phLHAVLGLsdGSTRGGHLLsGRV-WPTLEVVVRDSP 178 Streptomyces coelicolor
jgi:Snov_0411         92 lhLHAVLGLsdGSTRGGHLLdGIV-RPTLEVMITETP 127 Starkeya novella DSM 506
Q92X95               117 lhLHAVLGLedGSTRGGHLLeGYV-RPTLEVIIRESP 152 Sinorhizobium meliloti
goetting:OCA5_c30300  92 ihAHVVLGTrtGSAIAGHLKkANV-RPTLEVIVTESP 127 Oligotropha carboxidovorans OM5
CAL61860              90 shIHVVVGKrdGSAHGGHLLqAYV-RPTLEIILTESP 125 Herminiimonas arsenicoxydans
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