Conserved Protein Domain Family
Spt5-NGN

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pfam03439: Spt5-NGN 
Early transcription elongation factor of RNA pol II, NGN section
Spt5p and prokaryotic NusG are shown to contain a novel 'NGN' domain. The combined NGN and KOW motif regions of Spt5 form the binding domain with Spt4. Spt5 complexes with Spt4 as a 1:1 heterodimer snf this Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The Schizosaccharomyces pombe core Spt5-Spt4 complex is a heterodimer bearing a trypsin-resistant Spt4-binding domain within the Spt5 subunit.
Statistics
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PSSM-Id: 397481
Aligned: 48 rows
Threshold Bit Score: 60.2911
Threshold Setting Gi: 124460931
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6L1X2        130 VIVIAKCTIGKELDTAVDLSAKAETDLKERLisnknarN-EILSIMSPYEIKGYIFIETMHVDRVEYLARTLRNFKGIIS 208 Picrophilus to...
jgi:Nmar_0386   8 HLFAIRTTGGQEKVVMRLLEAK----ANANQ-------I-NIQSVFWVNDLKGYVVIEAINPSDAYMAVEGVRHIRGQLR 75  Nitrosopumilus...
jgi:Msed_1633   8 NFYAVKVTGGQEISVAIMLEER----IKTNG-------IgDVYSIIVPPGLKGYVIVESSGPHVVKFIIAGIRHVRGVAP 76  Metallosphaera...
P96036          8 NYYAIKVVGGQEINVALMLEER----IKTNN-------IkGIYAIIVPPNLKGYVVLEAEGLHIVKPLIAGIRNARGLAQ 76  Saccharolobus ...
P27341          8 NYYVLRVTGGQEINVALILEER----IKTNN-------InEIFSVVVPPNIKGYVILEATGPHVVKLISSGIRHVKGVAH 76  Sulfolobus aci...
Q971I9          8 NYYAVRVTGGQEINVALMIEER----IKTNN-------IkEVYSIIVPPNVKGYVILEATGPHVVKLVSQGIRHVRGFAQ 76  Sulfurisphaera...
Q9Y9W3          8 RFYAILVTSGAEVNVATIIAER----ARALG-------L-DIRSIIVPPRIKGYVILEAHDPGDVYDATRGLRHVKRRRP 75  Aeropyrum pern...
jgi:Igni_1179   4 PFFPVRTVSGREIDVALLIEER----ARAKN-------L-DVKSVIVPPRIKGFVIVESPAHFVVAEAVRGIKYVRGGPG 71  Ignicoccus hos...
WP_011839380    8 SFYAIRTTMGREIDVALVIESRIMDLVKQNR-------DpGVKAVFVPPGVRGYVFLETSRLASIYRLISELKYVKSGQP 80  Staphylothermu...
jgi:Cmaq_0952   7 VFIGVRVIAGQEYNVAAIIRTRLELMEKDKRk------YyNVPSIVVPPNVQGQVYLETPHSYVAIDLSTGIKQYRGLMM 80  Caldivirga maq...
Q6L1X2        209 GTVSMDEIEHYL 220 Picrophilus torridus
jgi:Nmar_0386  76 GELEFKDIEGYL 87  Nitrosopumilus maritimus SCM1
jgi:Msed_1633  77 GLVPKDDIMKMV 88  Metallosphaera sedula DSM 5348
P96036         77 GLLPRDEILKIV 88  Saccharolobus solfataricus P2
P27341         77 GLIQKEDVTKFV 88  Sulfolobus acidocaldarius DSM 639
Q971I9         77 GLVQKDDIIKFI 88  Sulfurisphaera tokodaii
Q9Y9W3         76 LILKFEEVMKLV 87  Aeropyrum pernix K1
jgi:Igni_1179  72 KKISLEEVLKMI 83  Ignicoccus hospitalis KIN4/I
WP_011839380   81 IKVSLDEVGRLV 92  Staphylothermus marinus
jgi:Cmaq_0952  81 GKVPLTELMKMI 92  Caldivirga maquilingensis IC-167
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