2A70,3WNX,2E6V


Conserved Protein Domain Family
Lectin_leg-like

?
pfam03388: Lectin_leg-like 
Click on image for an interactive view with Cn3D
Legume-like lectin family
Lectins are structurally diverse proteins that bind to specific carbohydrates. This family includes the VIP36 and ERGIC-53 lectins. These two proteins were the first recognized members of a family of animal lectins similar (19-24%) to the leguminous plant lectins. The alignment for this family aligns residues lying towards the N-terminus, where the similarity of VIP36 and ERGIC-53 is greatest. However, while Fiedler and Simons identified these proteins as a new family of animal lectins, our alignment also includes yeast sequences. ERGIC-53 is a 53kD protein, localized to the intermediate region between the endoplasmic reticulum and the Golgi apparatus (ER-Golgi-Intermediate Compartment, ERGIC). It was identified as a calcium-dependent, mannose-specific lectin. Its dysfunction has been associated with combined factors V and VIII deficiency OMIM:227300 OMIM:601567, suggesting an important and substrate-specific role for ERGIC-53 in the glycoprotein- secreting pathway.
Statistics
?
PSSM-Id: 397453
Aligned: 8 rows
Threshold Bit Score: 252.356
Threshold Setting Gi: 74675974
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2A70_B   3 DASKLSSDYslpdlintRKVPN-NWQTGEQASLE-EGRIVLTSN---QNSKGSLWLKQGFDLkDSFTMEWTFRSVGYsg- 76  baker's yeast
O42707  23 SQFLQLHSL--------SNAIPvEWKWYGSVDED-SGYVYLTSKdsnEARSGSLWSTSVLRQ-VGWQLSTSFVAHVSe-- 90  Schizosaccharomyces p...
Q22170  43 GYYKREHSLikpy-tgsgADIP-NWNIIGSTFVS-SNQIRLTADe--QSKAGALWNTQPVWS-RDWELQVSFKVTGStg- 115 Caenorhabditis elegans
Q9VCC2  33 DYMKREHSLvrpf-qgvgVILP-HWDFLGNTMVT-SNYIRLTPDl--QSKSGALWNYSPVMT-RNWEVHVGFKVHGKgt- 105 fruit fly
Q9V3A8  33 RRFEYKYSFkppylaqkDGTVP-FWEYGGNAIAS-SESVRVAPSl--RSQKGAIWTKSQTNF-DWWDVEIVFRVTGRgr- 106 fruit fly
3WNX_A  21 RRFEYKYSFkgphlvqsDGTVP-FWAHAGNAIPS-SDQIRVAPSl--KSQRGSVWTKTKAAF-ENWEVEVTFRVTGRgr- 94  human
O94401  24 TSHLERLSLeapyinhgMRNL--WWEYGGSTVIDrKNGIFLTQDv--QNQQGWISTRLPTPS-SSFEVLFQFRINSEst- 97  Schizosaccharomyces p...
2E6V_B   4 EHLKREHSLikpyqgvgSSSMP-LWDFQGSTILT-SQYVRLTPDe--RSKEGSIWNHQPCFL-KDWEMHVHFKVHGTgkk 78  dog
2A70_B  77 -qTDGGISFWFVQDSNIprDKQLYNGPVNYDGLQLLVDnng-------plGPTLRGQLNDGQKPVDKTKI-YDQSFAS-- 145 baker's yeast
O42707  91 -nENTFFAIWYTSAVGS--EGPVFGASDKWDGLLISQEidq-------tgKIFVRGYLNDKSFELAQFTDpDLPPFAK-- 158 Schizosaccharomyces p...
Q22170 116 dlFGDGMAIWYTSEPNI--LGPVFGGKDYFRGLAVFLDtysnhngphqhgHPFISAMVSDGSLHYDHDKDgTHTQLGGen 193 Caenorhabditis elegans
Q9VCC2 106 elFGDGFAIWYTKERMQ--TGPVFGSKDHFSGLAIILDtysnhngphnhqHPYLSAMVNNGSWSYDHDRDgTHTQLAG-- 181 fruit fly
Q9V3A8 107 -iGADGLAFWYTTEKGDy-NGPVFGSSDRWNGLAIMFDsfdnd---nkhnNPYISAVLNDGTKLYDHAEDgTTQLLSG-- 179 fruit fly
3WNX_A  95 -iGADGLAIWYAENQGL--EGPVFGSADLWNGVGIFFDsfdnd---gkknNPAIVIIGNNGQIHYDHQNDgASQALAS-- 166 human
O94401  98 slFGDGLAFFLAAERAK--PGPVFGFTDKFNGYGIFIDtynnh--rpgtlFPRVIVMKGDGHTPYDYENDgKANEIAS-- 171 Schizosaccharomyces p...
2E6V_B  79 nlHGDGIALWYTRDRLV--PGPVFGSKDNFHGLAIFLDtypnde-ttervFPYISVMVNNGSLSYDHSKDgRWTELAG-- 153 dog
2A70_B 146 --CLM-GyQDSSVPSTIRVTYDl------eDDNlLKVQVDNKVCFQTRKVRFPSGSYrIGVTAQNGAVNNNAESFEIFKM 216 baker's yeast
O42707 159 --CTI-E-SSPEALNNIILKYGd-------QSG-LELFVNDKPCFQVKDVILPQGYY-FGVSSQSTSAKDLVALSNLNIL 225 Schizosaccharomyces p...
Q22170 194 tgCTA-KfRNKDHDTQVLIRYVgdtlsifsD---IENKGIWNLCMSVNNVQLPTGYY-IGVSAATGDLSDAHDVVSLKMF 268 Caenorhabditis elegans
Q9VCC2 182 --CEV-RfRNVEYETLVSIRYEndilsvstD---LENRNEWKNCFVVANVELPTGYH-FGMSATTGDLSDNHDIHSFKFY 254 fruit fly
Q9V3A8 180 --CLR-DfRNKPFPTRARIEYYnnvltvmiHNGmSNNNDDYELCLRADGVNLPKNGY-FGISAATGGLADDHDVFHFLTT 255 fruit fly
3WNX_A 167 --CQR-DfRNKPYPVRAKITYYqntltvmiNNGfTPDKNDYEFCAKVENMIIPAQGH-FGISAATGGLADDHDVLSFLTF 242 human
O94401 172 --CSAlNvRGNDYN-LGKLKYDknakklrfEIAy-QGSSSFIKCFDLNEVELPLTTF-MSFSAHTGDLSESHEIASILSR 246 Schizosaccharomyces p...
2E6V_B 154 --CTA-DfRNRDHDTFLAVRYSrgrltvmtD---LEDKNEWKNCIDITGVRLPTGYY-FGASAGTGDLSDNHDIISMKLF 226 dog
2A70_B 217 QFFN 220 baker's yeast
O42707 226 PPDT 229 Schizosaccharomyces pombe 972h-
Q22170 269 EQEF 272 Caenorhabditis elegans
Q9VCC2 255 DLDL 258 fruit fly
Q9V3A8 256 SLHA 259 fruit fly
3WNX_A 243 QLTE 246 human
O94401 247 TITD 250 Schizosaccharomyces pombe 972h-
2E6V_B 227 QLMV 230 dog
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap