4B8C,1ATN,4AWN,2F1N,1I9Z,4GEW,5J3P,5OKN,4CMN,1ZWX,2VOA,2J63,5CFE,3W2Y,1AKO


Conserved Protein Domain Family
Exo_endo_phos
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pfam03372: Exo_endo_phos 
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Endonuclease/Exonuclease/phosphatase family
This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12, and Nocturnin.
Links
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Statistics
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PSSM-Id: 397447
Aligned: 319 rows
Threshold Bit Score: 35.3495
Threshold Setting Gi: 74870914
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4B8C_D        398 LSYNTLCQhyatpKmyrytpSWALSwdyrrnkLKEQILSYd----sD--LLCLQEVESKTFEEYWVPLLDk-hGYTGifh 470  Saccharomyces...
Q9YGS2         70 GLLNIRSllck------------------sllVHDLIADHh----iD--LFCLTETWLQEEEYVSLNEST---PPTH--- 119  torafugu
XP_001622016   40 IHLNINSCq----Nk----lDELLL-------LNKELRSH---------VIFLTETKIDSSYTNDQLALE---GYHI--- 89   starlet sea a...
XP_001621507  115 CHWNARS-----------------FnndkyeqIKEILTHPrt--eiD--VIIITETWLNSSHTNEEYGI----PGYH--- 166  starlet sea a...
EDO29189      164 GSWNVDC-----------------LtmpkfeqLKLLMLDKdsrpqvD--VLSINESALKPSIPDSLYSIP---HFDM--- 218  starlet sea a...
Q7M558       2777 FLMNVQNlk---------------------qhLADLIFRTqhl-qpD--CIAVTETWLPADTLSEAVHIDeysFHSQprs 2832 zebrafish
Q9NAL5        373 LLANVRSCk----Kl-----EKASQ-------LCAKLHSN------DyqIIAVTESWLQESVSSALFTSF---GISIh-- 425  Caenorhabditi...
Q08525         66 LYTNAHS----------------LSnkqdeleTVMHLESY------D--LVAITETWWDDSHNWNTTID----GYRL--- 114  chicken
XP_001851059 1836 MSINVQS----------------LRahqmdinTDPVLPRV------H--LLALSETWMDDNASIELEG-----FTRI--- 1883 southern hous...
EDS39870     1636 MTINVQS----------------LSahhqdisIDSILTSV------D--YLALSETWLDDNSSVEIEG-----YTCV--- 1683 southern hous...

4B8C_D        471 -akARAKTmh-sKDSKKVDGCCIFFKRDQFKLITKDAMDFSGAWMKHKKFQRTEDYLNRAMNkdnvalflklqhipsgdt 548  Saccharomyces...
Q9YGS2        120 ---LNYHIp---RVTGRGGGVAAIYHSKLLINPRPKHGFSSFESLTLGITHLNWRTEKPLLF------------------ 175  torafugu
XP_001622016   90 ----YRKD-----RKKGGGGLMAYFSSKMASRKVKLPKQYRLLEVLAINAIINNNNVLFVGIy----------------- 143  starlet sea a...
XP_001621507  167 ---IERKD----RTRKERGGVMMYVSHAMAYTRLPTLESSDTELLCTQVIPCKSNCPIII-------------------- 219  starlet sea a...
EDO29189      219 ---YRRDR----KGSKKKGGVLMYVNTDLKHKRRTDLEDTNIESIWMEIYPFKSNRPVLF-------------------- 271  starlet sea a...
Q7M558       2833 lsyHTTNPiltgLQTQQHGGVGIYASNKLLFNIIQIPNVNLECVVCNCIKYNILTAVIY--------------------- 2891 zebrafish
Q9NAL5        426 --rCDRDVa--lHTKNSGGGVAILFKPPLVVTKLDIQQEHHYNGHQSEVLACRVLNPDYPGA------------------ 483  Caenorhabditi...
Q08525        115 ----FRRD----RRGRKGGGVALYVKEWIDCEELPLRNSQEQVESLWVRIRDGTNKGQLV-------------------- 166  chicken
XP_001851059 1884 ----VQSK----RTGVRAGGVAIYQNTTAPNTTPATPYTLEVVGAERSQEFSEAAKYGDICAakvmvm------------ 1943 southern hous...
EDS39870     1684 ----VQSK----RDDARSGGVAIYRKTTTKTSMAVPYTPELVSQDRDELFGVADKYGDVCAAtvdvmg------------ 1743 southern hous...

4B8C_D        549 iwavtthlhwdpkfndvkTFQVGVLLDHLETLLKEETSHNFRQDIKKFPVLICGDFNSYINSAVYELINTGRVQIHqegn 628  Saccharomyces...
Q9YGS2        176 ------------------VVVYRPPAGPHSEFLSEFSDFLSDLVLRTDKVIIIGDFNI---------------------- 215  torafugu
XP_001622016  144 ------------------RSPNPTGTDYYRKLEEELHAVCMWASMECNTLVLTGDLNLDRLRPERREGQILINLEEv--- 202  starlet sea a...
XP_001621507  220 -------------------AGVYRVPDSTAEMDAKLEGLIEKMYITNKEALLLGDFNINFLKQQNHKHRLIKFLT----- 275  starlet sea a...
EDO29189      272 -------------------NGLYRPPSYCKEDDIALENNVESAYLLNFETIILGDLNINYLASSNFKKHRLVRAFT---- 328  starlet sea a...
Q7M558       2892 ----------------------RPPTYPMSLFKENLGKLLDFLELINSTIVVLGDFNDNIFKSSTICKFMTER------- 2942 zebrafish
Q9NAL5        484 ------------------SFNLVVVYRPPINGKISQLIAHLSSFLPSSEYVLMGDFNFKEMYEKGSYSVNSKHEFMk--- 542  Caenorhabditi...
Q08525        167 -------------------IGVYYRPPDQGEAVDEAFLLQMWEASCSQALVLVGDFNHPDICWKDHTASCKRSRRLv--- 224  chicken
XP_001851059 1944 ------------gaelllVSVYISPGTTTKQKLWFLSRHLGPIAELDTPMVVTGDFNLDVSKQDSSRFVEFMANH----- 2006 southern hous...
EDS39870     1744 -------------tevllFSVYIIPGTTLKQKGWFLARKLLQTARTGLPMVVTGDFNVDVSKRENVDFLKFMGEH----- 1805 southern hous...

4B8C_D        629 grdfgymseknfshnlalksSYNCIGELPFTNFTPSFTDVIDYI----------------------------------WF 674  Saccharomyces...
Q9YGS2        216 ---------------------------------------HMDVIndsfrngfisllesvgflqqinqpthsfnhtldlVL 256  torafugu
XP_001622016  203 --------------------FGLECLIKDPTRVTPTSETLLDVI----------------------------------LT 228  starlet sea a...
XP_001621507  276 ---------------------SLGFTQTINEVTRPKSQACLDHV----------------------------------YT 300  starlet sea a...
EDO29189      329 ---------------------SMNFKQLVTQVTRPISETCLDHI----------------------------------FS 353  starlet sea a...
Q7M558       2943 ------------------------GFVQHVTQTTTEKDTLIDHV----------------------------------YV 2964 zebrafish
Q9NAL5        543 --------------------FVISSKMTQHVCKATHNNNILDLV----------------------------------LS 568  Caenorhabditi...
Q08525        225 -------------------eCIDDNFLVQVVDRPTRGEVLLDLL----------------------------------LT 251  chicken
XP_001851059 2007 ---------------------FELRLSNDVKKTTTLGGTVLDLT----------------------------------FV 2031 southern hous...
EDS39870     1806 ---------------------FQLSLANDVRQTTTNRGTVLDLT----------------------------------FT 1830 southern hous...

4B8C_D        675 SThALRVRGLLGEVDPEyvskfigfpndkfpSDH 708  Saccharomyces cerevisiae S288C
Q9YGS2        257 TY-GVEVEHVSVFPQNPl------------lSDH 277  torafugu
XP_001622016  229 NK-PELFRASGVLNPEM--------------SDH 247  starlet sea anemone
XP_001621507  301 NQ-PQCITKTKVCNIGL--------------SDH 319  starlet sea anemone
EDO29189      354 NR-PERIHSIGTRDFAL--------------SDH 372  starlet sea anemone
Q7M558       2965 KTaHYNVEAIVLPTHF---------------SDH 2983 zebrafish
Q9NAL5        569 SP-GIVLENVKVQDCCVk-------------SDH 588  Caenorhabditis elegans
Q08525        252 NAeEIIKGVNVGGSLGC--------------SDH 271  chicken
XP_001851059 2032 KNtAVEVTRYTSYF-----------------SYH 2048 southern house mosquito
EDS39870     1831 RSiHVASNSRYACYF----------------SYH 1848 southern house mosquito
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