2KOU,6BU9


Conserved Protein Domain Family
Dicer_dimer
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pfam03368: Dicer_dimer 
Dicer dimerization domain
This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules. It is essential for the activity of Dicer. It is a divergent double stranded RNA-binding domain. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity. This domain has weak dsRNA-binding activity. It mediates heterodimerization of Dicer proteins with their respective protein partners.
Links
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Statistics
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PSSM-Id: 397444
Aligned: 213 rows
Threshold Bit Score: 47.1141
Threshold Setting Gi: 1005951622
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2KOU_A                 6 SISMMYKYCSRLPHDEFFQ-PKPEFQFkpvd---efggTICRITLPANAPI--SEIES-SLLPSTEAAKKDACLKAVHEL 78  
A2QX45               536 AVGYLYNFCSKLPAQLYVS-NKPLFTYernn----ygrFRAVVKLPSNLDPslQSFSSsRSWSRLKYAREDAALQAYKAL 610  Asperg...
XP_002377684           6 AISHLYRFCAELPAQPFVS-NSPAFSYetde----cgqVQAIVRLPSNLDPslQTFKSlRKWAKKKWAKEDAALQAYKAL 80   Asperg...
CCX32051            1263 SVPHLYHFCACLPPQEFVD-LRPQFQTtrsvgvdarvsWEAEVILPNSIHPdiRRFTTtKAWHTEKWAKRDVAFAACMKL 1341 Pyrone...
WGS:ABKH:PAAG_00072  578 ARQHLEHFCATLHYA-FTD-SRPHFIFhesk---edgmVAAKVILPNVLDPkfRVIHGsKRWKTERMAQRDAAFQAYLKL 652  Paraco...
XP_001541840         562 ARPHLEHFCATLQCE-FTD-TRPVFMFrene---lggmVTAKVLLPNVLDPkfRVIKGsKWWRTEKLAQRDAAFQAYLKL 636  Histop...
GAD94518             461 ARPYLEHFCSTV-SYSYSD-NRPDFIMhqyfg--dsglMKATAILPGFLDPslREICGqRSWMTERNAKREAAFQAYLAL 536  Byssoc...
EEA22574             574 AQPFLAHFCATG-SSAYTS-NQPEYIIdrqefapglaqIAAKVVLPSYIDPslRVAFSkSKWQTEKAAKRDAAFQAYVAL 651  Talaro...
XP_002485488         571 AQPFLAHFCATV-SYAHTT-NQPEYIIerqevslgftqITAKVVLPSYIDPslRVAFSkSKWRTEKAAKRDAAFQAYIAL 648  Talaro...
EHY60720             572 ARQSLQRFCSKLPRNADSEpPEPIFCLegei----glrIFAKVYLPTCLPPhlHVVSSqLGWQTERMAKKDAAFHAYLGL 647  Exophi...

2KOU_A                79 HNLGVLNDFLLPDSKDE 95  
A2QX45               611 YQAGLVNDYLVPTQVSD 627  Aspergillus niger CBS 513.88
XP_002377684          81 FHARLINDHFLPLRLSD 97   Aspergillus flavus NRRL3357
CCX32051            1342 HQLGQLDDNLMPLGKGD 1358 Pyronema omphalodes CBS 100304
WGS:ABKH:PAAG_00072  653 YNEGLVNDYLLPVHWKG 669  Paracoccidioides lutzii Pb01
XP_001541840         637 YQEGLVNDHLLPVHCMA 653  Histoplasma capsulatum NAm1
GAD94518             537 YQAGLVNDNLMPKHCEK 553  Byssochlamys spectabilis No. 5
EEA22574             652 YRAGMVDDNLTPLHRRK 668  Talaromyces marneffei ATCC 18224
XP_002485488         649 YDAGMVDDNLMPIHRKK 665  Talaromyces stipitatus ATCC 10500
EHY60720             648 YKAGLVNENLQPIHWPK 664  Exophiala dermatitidis NIH/UT8656
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