Conserved Protein Domain Family
Lin-8

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pfam03353: Lin-8 
Ras-mediated vulval-induction antagonist
LIN-8 is a nuclear protein, present at the sites of transcriptional repressor complexes, which interacts with LIN-35 Rb. Lin35 Rb is a product of the class B synMuv gene lin-35 which silences genes required for vulval specification through chromatin modification and remodelling. The biological role of the interaction has not yet been determined however predictions have been made. The interaction shows that class A synMuv genes control vulval induction through the transcriptional regulation of gene expression. LIN-8 normally functions as part of a protein complex however when the complex is absent, other family members can partially replace LIN-8 activity.
Statistics
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PSSM-Id: 397436
Aligned: 19 rows
Threshold Bit Score: 229.18
Threshold Setting Gi: 74965318
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003109960  27 ITKAIYTEKSK----KK--ATC---DVGKDINLKRVVLVVLEGKPEIWKHAA-RAEYSAWESVGIEVYERTEQIVSVLSL 96  Caenorhabditis ...
Q17809        33 ITMADYLLLEN----TK--FHK---TATRAPKIKKVLLSLLKDRPEIWDRKA-QFSAKNWQNLGVEVYERTGYIVRSNDL 102 Caenorhabditis ...
Q17810        34 ITMDEYLEKEN----RE--FVV---NASKDIAMKKLALTLLELYPEMWKPGG-PMVAKKWQAFGAEMYRRTGKIYRCKDL 103 Caenorhabditis ...
O17151        26 ITLEEYKEREK----KD--YYR---DATKDASVKKVVLSLLKDHPGMWQNGN-RFQPEKWRALGVDVYQRTGQIVRVNDM 95  Caenorhabditis ...
O17152        28 ISLSGYRNIHA----KS--FLK---TMTMDLCVRRVVLSLLENRRALWIRVH-KSPKADWEVLGVEVFERTGKAVSVKQL 97  Caenorhabditis ...
O17149        27 VSMEEYMGMEL----NS--VYE---EATKDSALKKVVLDLLKDRKAMWAPAA-KPSEDKWQKLGAEVFSRTGKVVSVTQL 96  Caenorhabditis ...
Q9TZ87         1 MNATDYRKLTEhiegTK---------FPMDNLIKKVFLNILEPKEDLWNSNQ-KIDRERWETVGIELFQRTGILVSVDQM 70  Caenorhabditis ...
2_pfamImport   1 MPTYRRISQHH--------SLP---DAQTRDDVRKTLFDLIHENPKMWDGVKlKTTIKQWEDIGLELWKRLDIVVSVDQM 69 
1_pfamImport   1 MPTYRRISQHH--------SLP---DAQTRDDVRKTLFDLIHQDGKMWDGVKlKTSLKQWEDIGLELWKRLDIVVSVEQM 69 
EFP06463      74 MTIKEYFSMSKipqiRTqkWNTinvPAKEKEALKLVILDSISRRPDILDIKNtSVIRLEYAIVAIQVFKRTGHILSSQLL 153 Caenorhabditis ...
XP_003109960  97 RRVFTLCKSSVKRKLRISILNQNLDTVQTETAMWSLPYYGEFKYYRETLKNFENKLRDRVFNEKFPPA--------TDDE 168 Caenorhabditis ...
Q17809       103 HKMLRTAKVVLKNKLRTCIGIKKLDRAATETELWKWEYYPHFIYYRETLGHFEANLRGEPWDGEAHIDd-------DDDD 175 Caenorhabditis ...
Q17810       104 HSVFTLTKSSIKRKLRTCILIKRMHRSKTDEEMWKYELYPYFQYYRQSIGQFEAKLRDEPWTGEDQAQ--------EDDD 175 Caenorhabditis ...
O17151        96 RKMLVMGKSVLKKKIAICIRDKKLDRAATEKDLWYWEYYRHFLYYRETLGQFEANLRGEEWTGEDQIQ--------DEDD 167 Caenorhabditis ...
O17152        98 QRIFLTARDWLRRNLQLYIIQRKMDKLTLDAELAKWELYPHFIYYRQYLGQFEAHLRGEEWTGEL-----------YDDD 166 Caenorhabditis ...
O17149        97 RRMLVSSKHVLKTKMSHCIKVKKMDRVSTEAYLQNWEFYRHFRYYRETLGQFEANLRGEQWTGEDQPAd-------DDDD 169 Caenorhabditis ...
Q9TZ87        71 RSGFRSIKSNLGQRLHNCVQSG-MSRIQTELELQKWELFQDLRFYYDKLYKYR-QLRAERTGNEARNS------------ 136 Caenorhabditis ...
2_pfamImport  70 KLAWRVVRDSIRRKLRTCIENQKMGPEETENSFGKWEVYGHIRFLRARFATYEEELRKEFITGEMADAdvireaerDEDD 149
1_pfamImport  70 KLAWRVARNTIRRKLRSCIENQKMGPEETEQSFIKWEVYGHIRFLRARYAKYEAELRKEFITGEAADAdvileaerDDDD 149
EFP06463     154 MYVFKRAKEQLRIHLRAAISTKLRSPAEVEQKLWEWPVYEFIRFYRVKLQDWETQFRQKHIKPADGQPvvfeidedQFED 233 Caenorhabditis ...
XP_003109960 169 IQFIGFGS------------------LEECedsddenyeGVPRHAEEETEMD--SSNDFEVGEQSQEHQYQddgvvnyya 228 Caenorhabditis ...
Q17809       176 IIYEGYWE------------------ADKN---------SSKLTSETQDSVD--ETIVEEVPLEPDTNVFD--------- 217 Caenorhabditis ...
Q17810       176 ILFDGLFEven------------nfvHNGLpameekvrfSANLHTDEQANMF--DTQTENVD------------------ 223 Caenorhabditis ...
O17151       168 IIYDGMLD------------------GDLS---------NSSHNFAGHGADD--DYQVEEVQYSEAG------------- 205 Caenorhabditis ...
O17152       167 IICDGIMQvevstrvfnnpaqdevpiVENYegyggsvasMAEAGGCEHAQMD--TSRGYEQSRQQKAAIGG--------- 235 Caenorhabditis ...
O17149       170 IIYDGIFE------------------VEMVdr------tREAQPAENQGNQE--EYHVEEVPYAQEEQVYE--------- 214 Caenorhabditis ...
Q9TZ87       137 -----EPV------------------SGEDmqsffeepdMMSLVEENDSAMKylSSLIPQVSSTSTPTKVK--------- 184 Caenorhabditis ...
2_pfamImport 150 VIFEGYHAp-----------------IESGsdivpdaptYIDYESPDQPQISipTDPMIQIARNQMGQQYTpmship--- 209
1_pfamImport 150 VIFEGYHAp-----------------MEIGsdtvpdaptYIDYLSPGQPQISvpTDPMIQVARNQMCQQYNpsshtp--- 209
EFP06463     234 MDddqyq----------------------------emsfSAQEELYEGTDIVgeATHQSESPPLLMANAKSeph------ 279 Caenorhabditis ...
XP_003109960 229 qsyrehgmmeevvNDQPVV-------GRYEEIGGSLNAEQDQHHGYemeevvndISVVGRYEEIDGSLNDEQQNQHQRYE 301 Caenorhabditis ...
Q17809       218 -------------REEEVV-------TFRRPEAFARAVDNHFGPPTeh-----lPDSSAKIYSTNIKSASCAPESTEPPK 272 Caenorhabditis ...
Q17810       224 ------------------------------------------------------NMMGAYTDSFSQIRHETSKSPMNAQS 249 Caenorhabditis ...
O17151       206 ----------------------------FRRPESVRGGDSYFGHGPppqm-vmgSSASNFSSATQSHSRNRKSSSIDHTE 256 Caenorhabditis ...
O17152       236 -------------YEQPQM-------ATPRGYEQQRMQREATGGCEqpq---vaAAFSSNFASASTSRSRKRPHSSIKQE 292 Caenorhabditis ...
O17149       215 --------------------------------------NQQQNQQTypm---hgGSPSSDYSTISAHSLKRRRSTT---- 249 Caenorhabditis ...
Q9TZ87       185 -------------LENPFL-------NAFENPMNLRHELSQM------------LQASSSSSSIPSPISPPVPNPKAEDE 232 Caenorhabditis ...
2_pfamImport 210 -------nqqisrISEELR-------EQLDANAALLPCSPNFR-----------DDGSSKFDIKTSRKRTAAEQLPSDSD 264
1_pfamImport 210 -------nhqiphINEEVI-------EQLEASAPLLPCSPNFT-----------DDGSSKFDIKSSRKRTAAEQLPSDSD 264
EFP06463     280 -----------qpLENPTTsgfpgemDQVGHMNDTEDHDQNGNQG---------MMIPANISNLTNDQIE------DMKD 333 Caenorhabditis ...
XP_003109960 302 YADALYHqdqpgpssrampvdhdalaIRNCMIQLFVNHPDRFEFHKGGIQKILDYLEKE--EYPDAVKTFGDLKYME 376 Caenorhabditis rem...
Q17809       273 SDNSAQH-------------------IGEQVHRLFAQYPERSKLFRETLFKTILALEEP--EYEHAAEVFTDLAQSE 328 Caenorhabditis ele...
Q17810       250 INASIEYenvpvrq-----idktadnIGDQVKQLFVDHPDRANFFREVLFKTVLELRDP--AFTNAGVFFDEMSSLE 319 Caenorhabditis ele...
O17151       257 VDRSAQH-------------------IAEQAKRLFLQYPEKSNLIRETMFKTILAFDDPsaDYQNVGEIFDDLAAQE 314 Caenorhabditis ele...
O17152       293 DSVSYTK-------------------ITED---LLQKKPHKHRFIRQALFKTIMALDDDevEYTELADLFGDIAEQS 347 Caenorhabditis ele...
O17149       250 VDSTAEQ-------------------IGEEIDRLIQLYPQREMLIRQAFFKTIFALEDEtvEFSNLGDLFEDLAEQE 307 Caenorhabditis ele...
Q9TZ87       233 EKPSLKRpresspa------aveterISQQIKRIFEQYPEKTNLIRSVLTYTVLAFDEPdaDFSTASEVFGDLAARF 303 Caenorhabditis ele...
2_pfamImport 265 LTAQH---------------------IGHEVKRAFRQHPEKESLIRQSFFTLLMAFDDEeaDYQSMGDIFNDLAAQC 320
1_pfamImport 265 LTAQH---------------------IGHEVKRAFRQYPTKESLIRQSFFTLLMAIDDEeaDYQNMADIFNDLAAQC 320
EFP06463     334 FEISMDH-------------------ITHQANCVARRQPEKIDSIRQAMFLAVLEMEKS--DATDLGEFFAGMAKLh 389 Caenorhabditis rem...
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