Conserved Protein Domain Family
CDC37_N

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pfam03234: CDC37_N 
Cdc37 N terminal kinase binding
Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain pfam08565. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.
Statistics
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PSSM-Id: 397372
Aligned: 103 rows
Threshold Bit Score: 68.7834
Threshold Setting Gi: 344239579
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006678974           64 KWDSIELSDDEDFECHPNVDKKSMVRWKQAQVHKERKERQDQLDLLTLE-----HQTTEKYLADFKNQVKA----TFEAL 134 Batrac...
EPB86829                7 KWDNLELSDDSDIEVHPNVDKRSMIKWKQEAIHRERAERKAKIDYLTQF-----VPQQENVLKKVQELTSMlkntEDDLA 81  Mucor ...
EIE85021              152 KWDNLEISDDSDIEVHPNVDKRSMIKWKREAIHRERAERKAKIDYLQTF-----IPQQKNVLKKLKDLQELt--qEPDGI 224 Rhizop...
EGV95682                6 IWDHIEVSDDED-ETHPNIDTASLFRWR----HKARVERVEQFQKEKDEldrccRECKQKVAERQHKLREL------EVA 74  Chines...
EGF98706                7 KWDALELSDDSDVEVHPNVDKRSFIRMKQRKIHQEREERKMKIESFKHE-----EELNQKLLKEMKDLIKEv--eSDGIQ 79  Melamp...
WGS:AAWC:PGTG_05453.3   7 KWDSVELSNDSDLECPPAINKEKNAPPKHCQTHQQHECRKAEDKAFKWT-----GKLNGINIKQLQQLLTNi--dKKGVI 79  Puccin...
XP_003322766            7 KWDSLQLSDDSDLEDPPAIDKEKDASHKHCQTHQQHECRQAEIEAIKWT-----GKLNAIVIKKLQQLLTNt--dKKGVI 79  Puccin...
XP_003330284            7 KWDALELSDDSDIECHPNVDKRSFIRLKQRQIHQKRDERKMKIDGLKKE-----GPMNAALLEKIEELVAKt--kQDGAD 79  Puccin...
EFI99790                7 KWDALEISDDSDIEGHPNVDKNSLIRWKQRDIHEKREARKARIAYLQAQ-----IACNKVIHPRITTLLAEy--dENTKS 79  Schizo...
CCA70879                8 KWSKLELSDDSDIEGHPNVDHASLVRWKQRDIHEKREQRKFKIAQYEQE-----LKNNDALYPRLVSITEA-------VK 75  Serend...
XP_006678974          135 SR-PVTASAIIDTLkkiqtdTEKTYTDPMRTKSmscmnawpreweapnwgtvLrEHVPWHDTVakIQEAVSKISQEHAG 212 Batrach...
EPB86829               82 GI-KKVVQVLDQQQ------TEADPNMKVPSAG---------------------GKEMDVAQV--FSAMKTQIAAGLAS 130 Mucor c...
EIE85021              225 Q---KVLETLEHYQ---------SEASGLPKAQ---------------------GSEITVKEI--FAAMKAQITTGMAQ 268 Rhizopu...
EGV95682               75 E-------------------GSGQVELERPRAE---------------------PQQQCKEEQswKQKLGDTPKKSMPW 113 Chinese...
EGF98706               80 S--------MKKTA------SQLSATGGSVPPS-------------------EnK-EPTIQQM--VFNLLTQILSKVEK 122 Melamps...
WGS:AAWC:PGTG_05453.3  80 H--------LREAS------AKLLARGQGDSAR----------------------------TA--LFRYIDDTLHRIKD 114 Puccini...
XP_003322766           80 H--------LRQAA------AKLSTQGHGKSSL----------------------RKDSARTA--VFRYIDDILYRIKD 120 Puccini...
XP_003330284           80 H--------LRKTA------SKLSAEGHAKPPS-------------------SsEDQPSIDQM--IFNLISQILTKIKD 123 Puccini...
EFI99790               80 MpgtKYFNNLIEQM-------QANPSKECPPGNd------------------PnKIEQTYDGM--ILNLLQQVADQARK 131 Schizop...
CCA70879               76 QggpPAYSSTVERL-------KSSPSPEAPGPG-----------------------QKKYDEM--ILDALMSVWEECKK 122 Serendi...
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