Conserved Protein Domain Family
BcsB

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pfam03170: BcsB 
Bacterial cellulose synthase subunit
This family includes bacterial proteins involved in cellulose synthesis. Cellulose synthesis has been identified in several bacteria. In Agrobacterium tumefaciens, for instance, cellulose has a pathogenic role: it allows the bacteria to bind tightly to their host plant cells. While several enzymatic steps are involved in cellulose synthesis, potentially the only step unique to this pathway is that catalyzed by cellulose synthase. This enzyme is a multi subunit complex. This family encodes a subunit that is thought to bind the positive effector cyclic di-GMP. This subunit is found in several different bacterial cellulose synthase enzymes. The first recognized sequence for this subunit is BcsB. In the AcsII cellulose synthase, this subunit and the subunit corresponding to BcsA are found in the same protein. Indeed, this alignment only includes the C-terminal half of the AcsAII synthase, which corresponds to BcsB.
Statistics
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PSSM-Id: 397333
Aligned: 61 rows
Threshold Bit Score: 274.161
Threshold Setting Gi: 163668802
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
IBRC:GU3_14405    34 WPVQRSFEQLAQS-RDLMLRGVKNSQVINFALRRD-RIAKNGE-----LTLAYTPSPALLPGLSHLRVYLNEVLMDTLVI 106 Oceanimonas...
Q2K9Z0            92 QPRHRDFRRYLVPfSKFSLSGEYDRRSWSVYLTPE-QAAAKAS-----FTFAYQNSIVVAPEASALTVYLNNRPIGQQRV 165 Rhizobium e...
WP_015918144      60 TTANSSFQRYVVPfAKFRLEGEYDRKSWSIYLTPE-QAAAAAK-----FNFAYQNAVVVAPEASQLTIFLNNRPIGQQQI 133 Agrobacterium
Q7CS46           164 SLNADSRRRYILPyEKLSLSGEIDRRQWSIYLTPE-QANAAVS-----LNIGYQNAIVVAPESSNFQVSLNNVALDAARI 237 Agrobacteri...
O67400             7 QTTSVKLSEFLGK-NVLDLKGMDARGKLSFPVNPL-WNVEKIK-----FYIYYKASPVLKSERSEITLLLNGKVITSRQI 79  Aquifex aeo...
jgi:Msip34_0040   19 NTQQVELDKLIAA-PTLTLKCTGDEQGLDIPLAHR-WNVKKVT-----LNLHYVSSINLITSQSQLVVKLNGMPIAQTKL 91  Methylovoru...
jgi:Caur_1953     30 GAIHR-FADLGY--GDRTAFGIDTVLDYYFPIPTGlRPRSNGV-----LTLRFTHSPLLRADRSTITVVFNGRALGSARL 101 Chloroflexu...
jgi:RoseRS_3820   39 DQNVVAFERLGVT--DQTLSGVFDGTRYLFNIPAN-WRLASGAqaqldLSVFFPVGSAQQRLGGFLEARFNRVLIGTVEL 115 Roseiflexus...
CAL82847          31 KSKNFRVE------KDMKMEGVFGSNVFFFNIDKS-WTVDNAY-----LNLIFTESDLLDKTQSTLTAYINDFPVYSMKI 98  Clostridium...
jgi:Riv7116_5438  65 iTHNLEFNRAPIVgNRMRLRGIYSEGRLGFTRPRG-WNIGNVK-----ASIRFQHSPALYANRSNLTVLVNDTAVGSVPL 138 Rivularia s...
IBRC:GU3_14405   107 AEGEPGRQvQRQVRLDP-R-L--ITDFN--------QIRIEFVGHYTDI-CEDPAHSALWLNLAK-NSRVSLTEQALALT 172 Oceanimonas...
Q2K9Z0           166 SSADGSSA--VTFEVPS-GlL--QPGAN--------LVTFQAEQRHRTD-CSIQSTYELWSNIDPaGTYLSFAGGNAAEL 231 Rhizobium e...
WP_015918144     134 GSSDNPST--ASFDVPR-GlL--QPGAN--------LVSFEATQRHRTD-CNIQSTYELWSDIDPaRTYLSFTEENSQKL 199 Agrobacterium
Q7CS46           238 EAPDSEGN--VALKIPP-GvL--QVGSN--------VVTLGVQQRHRTD-CTIQSTYDLWTDVNPaNTYIGFNSDVAGSF 303 Agrobacteri...
O67400            80 KDEG---L--ITVEIENpKlF----DFN--------TLTFKASQHYCINcCENENSPELWTQIDLkKSYIQFQYTKKPFP 142 Aquifex aeo...
jgi:Msip34_0040   92 DALSPDVL--VQLNLPV-QyL--SAGYN--------KLSFAVAQHSESKgCEKGCSPDMWTTIDLkRSVLAIDYENKAVP 158 Methylovoru...
jgi:Caur_1953    102 TPDNAEEG-VLSVVLP-------IAGFDgpglfiqvRLHMRLTDDI----CEEVQNPALWTVVQG-DSTLRLDLQPVEAG 168 Chloroflexu...
jgi:RoseRS_3820  116 TQ--PGDR-RVVFDIPD-RaLtpVRSDG--------RHEFEVALDNPTG-CDVAPSERTAVVIRS-TSRFVLPHTLAPLD 181 Roseiflexus...
CAL82847          99 GDKKKYKE-SIKINIPKdK-L--ISGYN--------EVKIKVYSRISEKpCIDDVNSGNWFIIHK-GSYVHMDFKDREDT 165 Clostridium...
jgi:Riv7116_5438 139 NRKNSQIG-ELLVNIPP-K-L--LQDYN--------ELKIVAQQNNSEI-CTNPNDPNLWTEILP-DSKLVFNFQRKSVA 203 Rivularia s...
IBRC:GU3_14405   173 NDLSYFPQPFFDTSDN-EPLRLN-MVLPGAP-DTATLQSAGVLASYFGSLA-GWRGAGFEVSYDALPLLD-DRaplariM 247 Oceanimonas...
Q2K9Z0           232 SSADAIRAIGVDGA---GRTEFD-IVVPALE-QPGTTKPLLRLAQGLSVLS-SMPNQIFAFSTASLPTAG--Pgk--lgV 301 Rhizobium e...
WP_015918144     200 SGTDAIRAIGVDGA---GKTEFN-LVVPALA-QPGTTKPLLRLAQGLSVLS-GMPNETFSFSTDSLPPPG--Pgk--mtV 269 Agrobacterium
Q7CS46           304 ANIDDIQATGPDGK---AMTSIE-IVAPALG-NPAFADSLLRLSQALALRT-QMPNQTIRFv--TAPSTErKAgt--ltV 373 Agrobacteri...
O67400           143 ENLAFLKDIYLSERLL-SPVEID-ILTDKG--SNRLLTAGAIFSGYLGAKI-KYRRIYVNY-------TE-NLrakdtvV 209 Aquifex aeo...
jgi:Msip34_0040  159 VALSSVGTLLFDPKVF-PQAEVH-LVTDTQ--DGELLNPLSIVASGVAHHF-DYRQVSFTVSRQLKPGVD-NI------L 226 Methylovoru...
jgi:Caur_1953    169 T-LADVAALFAPLPLSaPEVRAPpTIVLHPTtEPSTLAAAGQVAFAIGRWA------ALAQ---QAPVLT---------V 229 Chloroflexu...
jgi:RoseRS_3820  182 TDLRNLPRPIFQGSFEpDQAT---IVIPDTP-SISDLQAALTVAASFGRLTeGRLQIDLTTVQRLSPQAR-TGr----hL 252 Roseiflexus...
CAL82847         166 KTLKEFPFPYLKASDE-NPANSM-IMLPDNF-SQGEITSAMMLCSNFGSKR-KSDNVNMKV---YKASEA-NLknkldiI 237 Clostridium...
jgi:Riv7116_5438 204 ENFSRYPYPIFDKLGL-EASKIN-YLQPTNV-DPTWLTAASRLQASLGRKA-DFRSLDADLVTD---------------I 264 Rivularia s...
IBRC:GU3_14405   248 V--------------LATNDHRPAFMadktLYPP-------V---DKA---EVRL------LDHP--------------- 279 Oceanimonas...
Q2K9Z0           302 L--------------VGTAAELRPFFpglpPGAE-----------SAP---LAAF------VTDP--------------- 332 Rhizobium e...
WP_015918144     270 V--------------VGTPAELQPLFpt-pAAAQ-----------NAA---LATF------VRDP--------------- 299 Agrobacterium
Q7CS46           374 F--------------VGTAREIAGVAgalpPEAS-----------AGA---FAGFgnagpgNSSP--------------- 410 Agrobacteri...
O67400           210 Igtqdfvs------------------------------rvigervSGN----IYV------TQNP--------------- 234 Aquifex aeo...
jgi:Msip34_0040  227 VgkhafvqgllgeskLALTDHEQGGYvsmlPLPQ-------A---GGG-------------------------------- 264 Methylovoru...
jgi:Caur_1953    230 S--------------DTVPEQLPTIVvalaSLPEgnwgsvrW---NGR---AYEV------DGQE--------------- 268 Chloroflexu...
jgi:RoseRS_3820  253 I--------------LVGSHTGLAPLarnlDLPAtlrengfAapgATPddgILQM------IVSP--------------- 297 Roseiflexus...
CAL82847         238 F--------------IGSKNNTPLDLltllSKEEinr------ldKDA---IVKE------VISP--------------- 273 Clostridium...
jgi:Riv7116_5438 265 T--------------KVKSNEKVVII----GTPQ-----------EQP---ALAE------IDLPitvegnkilnkeqtv 306 Rivularia s...
IBRC:GU3_14405   280 ------------DSPYAKI----------LLVQGKGNDELARAVRALALGGkLL---RGERAVIEQAEPLTP--RK--PY 330 Oceanimonas...
Q2K9Z0           333 -------------RSGSPV----------LLISGPSWQAVSSAIDTIVSPTdRSadvRRDTLTT----------ERwsAP 379 Rhizobium e...
WP_015918144     300 -------------RTGSTV----------LLISGPSWQSVAAAIDIVVSPTdRDpgiRRDLLVT----------QRwsAP 346 Agrobacterium
Q7CS46           411 -----------------------------LFVTGPTPQAVQAAIETLFSSIsRTpgaQRTTFST----------RSwhAP 451 Agrobacteri...
O67400           235 ------------KDKSKFL----------LVFTGRDEKEILNAVRAFILTPsSY---LSEKFVYVSDVVLPE--IK--AY 285 Aquifex aeo...
jgi:Msip34_0040  265 ------------QDAGHAL----------VVVTGKQVDDVKLAAETFASMStF----PGTPSLSAYEFKLPK--LR--EY 314 Methylovoru...
jgi:Caur_1953    269 ------------VPPDHGLlmvepaspprLLVAGATPTALRFAAQALST--------SLPAAAVLAVTQPPP------QL 322 Chloroflexu...
jgi:RoseRS_3820  298 ------------WNSERVV----------LVVSGASEAAVVKAARAL----------SAVPVRINNRPNVAVv-RD--LP 342 Roseiflexus...
CAL82847         274 ------------YNPSKKL----------LLLISNNEKNMIKASKLLCSKDyMKq-iDKDTIIVNNSMDVEDikEE---- 326 Clostridium...
jgi:Riv7116_5438 307 vpddrgvlimttTESGSPV----------LIATGNGKEGVEKAIKFLVQSDtSKm-gSGQVVVVDKVPELPTpgER---- 371 Rivularia s...
IBRC:GU3_14405   331 DAPNWTPTDRPVRFAELVEYPG----QLQASGLIPDPIELTVRLPPDLFVWQNQGIPLQTRYRYTAPTAND-D-SRLNIS 404 Oceanimonas...
Q2K9Z0           380 NAP-LVFSETSIALSQLGVKTT----EFSGRRFR---ASFNVAVPADFYANAYGEAKVLLDAAYTDNVLPG---SHIDIY 448 Rhizobium e...
WP_015918144     347 DAP-LILSDTNLSFSQLGIETT----EFSGRRFH---TSFNVAIPADFYANAYGEATIYLDAAYAKNVRPG---SHIDVY 415 Agrobacterium
Q7CS46           452 DVP-LVMSDRRIALSELGLQST----EFSGRRFR---TEFYVGMPADFYASAYGEASLLLDAAYSSQVLPG---SHVDIY 520 Agrobacteri...
O67400           286 SSPVLLAPGEEITLRKIAGG------DVVVRGY-AGRFDFSFFIPPDLMLNPKEKLRLKLFYNHGLLVREG---STINLY 355 Aquifex aeo...
jgi:Msip34_0040  315 SGRELIEPGKEYTLKALNFP------TATFQGGNASGKDINFRLPPDFMIRPNLSAKLALHFAYGAGMRET---SAMNIV 385 Methylovoru...
jgi:Caur_1953    323 PAAAW--RDGAASFAQLGVD------RRQVVGAGEHQIDFAFERPSGWDVRVGGTLDLQI----ATASGLRaQtSWVSAA 390 Chloroflexu...
jgi:RoseRS_3820  343 EAPADVALAIDQRLSDLGLEPR-------VIRDRTGTFDLRFTLPPGQQIDEGAYFDLTFNHAAT----VDfGqSSLSVG 411 Roseiflexus...
CAL82847         327 -------KANRVSLSDLGYG------NVSLKGPFKQEATFNLNIPKDRFIKEGSKVVINNRYS----KNIDfDrSLITVY 389 Clostridium...
jgi:Riv7116_5438 372 QWPRYLPEKNSFQLSEITAENEekfkDVTVRGAGAPAVEIDFRALPDDRFLRGSS--MNLVYSY--GPQLNpRtSAVEVL 447 Rivularia s...
IBRC:GU3_14405   405 INGEFIGSLPLTA--ERDNQleklrlavtssetanarnQ--LMVPSLKIGT-SN---------TIRYDFSFASTfgsaQP 470 Oceanimonas...
Q2K9Z0           449 VNDNIASTVPLTSttGGILR------------------HlpIRVTMRHFKPgLN---------TIGIETILMTK----DD 497 Rhizobium e...
WP_015918144     416 VNGSIATTKPITSpgGGIFR------------------KlpIRVTMRHFKPgLN---------TVTLEAMLLTN----DD 464 Agrobacterium
Q7CS46           521 VNDQIASTVPISNngGGIFR------------------HlpIKVTMRHFKPgPN---------KVTLEAVLMTA----QD 569 Agrobacteri...
O67400           356 INGKFVYSIPVDPydKSDLK------------------VreVLIPTSVLNKgFN---------VLTVESALVPN----KE 404 Aquifex aeo...
jgi:Msip34_0040  386 VNGKIVKGIHLGNtdGASFQ------------------NyvIEIPTRLFQPgSN---------RISFATELHPPl----- 433 Methylovoru...
jgi:Caur_1953    391 VNGITLGSQRLQVetNVPV-------------------QyrFTLPADLLNSdLEgtpirrldlQIRLYLDL-------PN 444 Chloroflexu...
jgi:RoseRS_3820  412 LNGIPIGSVRFSDetTRVT-------------------TgrITIPPSATRSgAN---------VLTIQTNLV------PR 457 Roseiflexus...
CAL82847         390 INDIPIGSKKLDSktADSN-------------------SfeISIPKDIRNSsNY---------EIKVVFNLEI-----KD 436 Clostridium...
jgi:Riv7116_5438 448 LDGNFIGGERLSSesGETRK------------------NlkVDLPPKLIKP-NS---------KIEVFFRMNARep-fNN 498 Rivularia s...
IBRC:GU3_14405   471 GRCQ--TTLVVdSRAVIDENSVIDFSGYHHFMAMP----DLGAFVRSG-FPFSRMADLSDTLVLMPASPSPLQTGLMLET 543 Oceanimonas...
Q2K9Z0           498 AACApgATAGAnPRFALFDTSEVHIPDFARVGQRP----NLAAISGTA-YPYGRA---TEPTPLFIDRVDADTLSAAATL 569 Rhizobium e...
WP_015918144     465 DVCTpgTTADKtARFALFDTSTFQIPDFARVAQRP----NLAAFAGTG-YPYGRS---STSTALFIDRTDTDTLSATATL 536 Agrobacterium
Q7CS46           570 QACApgAPASAtPRFALFDTSEIHIPNYAQIGRKP----DLAAMAGAG-QPYRT----GGPVALSLDRFDTDTMSVAATL 640 Agrobacteri...
O67400           405 DFCA--AANFEsLKVIIYGNSLISLPDLVHWTKMP----NLVYFISTG-FPFTTYPDMKDAAVLVEST-DGETLSSMFTL 476 Aquifex aeo...
jgi:Msip34_0040  434 kECD--LMLTGnMFLTVFDDTTFSFPDMPHFVELP----NLELFMLSG-FPFTRWADGYESKVVLTQT-DDNTLSAAMNL 505 Methylovoru...
jgi:Caur_1953    445 SGCE--EVDPSaAWAVIEPTSAWRLPN------------DPAAVDDLGrFPAALLAD-TNARLVLPPQPTIYEVQAGLEL 509 Chloroflexu...
jgi:RoseRS_3820  458 SLCT--DVRNTdLWVTIWPESALHLP-MKPVTAEPrrtfNLSSYP----LPFTLNPSLATTAFVVPQRAPAAWNAAAL-L 529 Roseiflexus...
CAL82847         437 LFCT--FREGEnPWAYILNNSYI----YTPYKEGR----D-NVFENYP-NPFISNGGMNDLTLVLSDNTTSEELNFAGNI 504 Clostridium...
jgi:Riv7116_5438 499 ESCI--YAPDQqLTGTLHNETSFDLKR-ETSATLP----NLELL-QFG-FPFASPQDLSQTTIVVPKNPSKTNVLTLLEF 569 Rivularia s...
IBRC:GU3_14405   544 LARIAAQTGY----PALALRL-----TQDPAVL--RES-ELDLLVFGPLPEGLT-----------QApAASLN------- 593 Oceanimonas...
Q2K9Z0           570 LGQMAVKAGH----PIAVETV-----ASPNTIG------DRDAIFIGSISQMPAtal--------tqaNISTAsqaswrp 626 Rhizobium e...
WP_015918144     537 LGQMAIVAGH----PIAVDLI-----ASPGSAG------DRNAIFIGPISQIPVttl--------sqmNIAAAsqaswrp 593 Agrobacterium
Q7CS46           641 ISRLASVAGH----PIDIETV-----ASPLVIG------DRDALFVGTISQFPQali--------sqfNLVPSsqiswkm 697 Agrobacteri...
O67400           477 LAFIGTKIQF----PPLRLSV-----YVDRLPN--DVAqSKDVIVFWNRNSLIKkqilnsldsvvLVkGKLFE------- 538 Aquifex aeo...
jgi:Msip34_0040  506 IGLMTQKSGF----PLYAIQL------DKAL----ANPwKGDFIMLGSPDSISAalggkslpftkGKsAVPYAlv----- 566 Methylovoru...
jgi:Caur_1953    510 AAAMGRWVTLkdvpPPILLTA-----NDIGDNR------NGPLVILGSRERHPLaami----ntpSNtPFVYQ------- 567 Chloroflexu...
jgi:RoseRS_3820  530 AFQMGRQTRD----AILQPLAvfadnVPTDVRE------SYHLLVIGRPGTLPIlve-----lgdAL-PAPFDa------ 587 Roseiflexus...
CAL82847         505 MATIGHDVDT----NRGKFNA-----VAAKDLS--SKLkKGNLIIIGTPESNSIikn--------snkNLYIK------- 558 Clostridium...
jgi:Riv7116_5438 570 SERLGRLSQA----PSVKLDV-----YTPDTLSndESAkNNHIVAIGTQNNFPIsea-----lekSQ-GLNLSq------ 628 Rivularia s...
IBRC:GU3_14405   594 ---QptDWLMQAANASPLQA-WPPSRLNK------THFDANAKVAVSAEGP----LAAIVGMESPYAPGRSLVAL 654 Oceanimonas sp. GK1
Q2K9Z0           627 vvdTqpGVIDTGTAFEEWDSkVSGGILRSritafrEWLGRNFDITRSS-------LQFIPGAEKVFTPSNADTlm 694 Rhizobium etli C...
WP_015918144     594 plpGqvAQQESAATVDEWRSrIGGGLLQLqlqsfqDWMHRNFDISWSS-------LQFIPGAEQIFTPSNlnsfm 661 Agrobacterium
Q7CS46           698 gtgVqvPAQNSDTLFNDWRErVDGGIWEGqvssfeEWMKRNFDLSSDT-------LRFLPAAEQPYAPPGNVSFm 765 Agrobacterium fa...
O67400           539 ----------------------------------------EDQKEFSVNLRkrdyVFTMAMRESPFKPKRTILVL 573 Aquifex aeolicus
jgi:Msip34_0040  567 ----------------------------------rDWASDPVLISSVQSSQlgegQGYLMQFESPYESGRTGMVf 607 Methylovorus glu...
jgi:Caur_1953    568 --------------------------------------------------PgrsvQATLSIVPSPWQSGAHVLFI 592 Chloroflexus aur...
jgi:RoseRS_3820  588 ----------------------------------gSDVPRSVDTPVVYRVPpdasVAYLQMVAAPWNPERVVVAA 628 Roseiflexus sp. ...
CAL82847         559 --------------------------FNKnfngflSNEKMKFFQDYSSK------LASIQLIDSPYNKENKAMIV 601 Clostridium botu...
jgi:Riv7116_5438 629 -------------------------SFFRlfgneqDKEQVKLQIPQDSQGM-------IKQIISPWNNDRVVLAL 671 Rivularia sp. PC...
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