1KHX,1MR1,1YGS,1U7F,5C4V,4R9P


Conserved Protein Domain Family
MH2

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pfam03166: MH2 
MH2 domain
This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C-terminus of MH2.
Statistics
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PSSM-Id: 397330
Aligned: 87 rows
Threshold Bit Score: 83.8792
Threshold Setting Gi: 38422270
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1KHX_A          32 AFWCSIAYYELNQRVGETFHASQpSLTVDGFTDPSNSeRFCLGLLSN-V-NRNA-TVEMTRRHIGRGVRLYYI-GGEVFA 107 
XP_011664649   662 EAWCKVYFMEKRCRLSDYQIKSP-AMIVDGYAFQHPg-RLGFGALAN-PlRDPEtK--KVREHIGKGVQLEIDsEGNVWA 736  purple sea u...
CAP33708        49 EIWGKIVIMERCKRVAKAYLRKT-TVIIDGSEDEFDGkTLGFNHFDN-PtRDDHtK--EIRAKIADGVILKMDyQGNIKG 124  Caenorhabdit...
XP_025016728    97 DIWAKVIFMERNRRVAKAYVRAQ-VITFNGSERGFDGhLVGLKGFAN-SkRDERtA--KVLEDLGEGIKMKIDeSGDILI 172  two-spotted ...
XP_015789242   134 EIWAKVICMEKNRRVAKAYARLP-FLIVDGSDIGFDGiRVGLKGFEN-IdRPEKtK--EILETFGEGVKIKMDgKGNILI 209  two-spotted ...
XP_015782979    53 EIWGKIICMERNRRIAKAYARVP-VLTVSGSDDGFDGfKIGLNGFDRaPsRDPLvK--RVRDHIGEGVRIKMDeFGNIII 129  two-spotted ...
EEB17140        25 EIWAKVILFERNRRIAKAYARAP-VLTINGSDDGFDGfRIGLNGFDN-PmRDKDtL--NCKRLIDHGVKIKMDdQGNILI 100  human body l...
Q7QJC4          16 EIWAKVIVFERNRRVAKAYARAP-VLTINGSDDGFDGmRIGLCGFDN-PmRDHKtE--EVKRHVGQGVKIKMDdAGNILI 91   Anopheles ga...
21_pfamImport    1 EIWAKVIVFERNRRVAKAYARAP-CLTINGANDGFDGmRIGLCGFDN-PmRDTQtD--EVKKRIDQGAKIKMDdYGNIFI 76  
4R9P_A          57 EIWAKVIVFERNRRVAKAYARAp-VLTINGSDDGFDGmRIGLCGFDN-P-MRDQ-KTDEMKRVIGQGVKIKMDdAGNILI 132 
1KHX_A         108 ECLS-DSAIFVQSP-NCNQR-YGWHPATVCKIPP-G-------C-----NLKIFNNQEF--AALLAQ------------- 156 
XP_011664649   737 TRLG-KNEVFVKGcfepe---nhcisAEVVASMGrl-----prNq----AMKVFDIVEYkaQLAIEAkkgngqidhhrlk 803  purple sea u...
CAP33708       125 MARG-AAPIVCQGwkepr---nncisDRVVRLHGkLnhgvtedEk----AYKVFDMRKF--KHALERelhdgtpdarsll 194  Caenorhabdit...
XP_025016728   173 KRLT-RSNVKVSGstpdy----nclgSELIESNGrl-----emDr----AMTLFQMKKL--ISTIGSeirstypnqrrle 236  two-spotted ...
XP_015789242   210 KRVG-KAAVYVKSfvgssdglgscigKDIIESKGkl-----eyKk----VSTLFDIRSF--QAGISAelkatypqtqkle 277  two-spotted ...
XP_015782979   130 KRLS-HCDVFIRGydrea----nsisKGILDLDGel-----tlEk----SVKLFDMKKF--QSGLNKelrsaypdrrrle 193  two-spotted ...
EEB17140       101 KRVSnKCKIFIKNtspngt-detsigSDVLKSGGnNsl---epDk----PYKLFDMTKF--QQNVTRelqraypdrrrle 170  human body l...
Q7QJC4          92 RRYS-KSNVYVKStanqpn-eetaigADILKLPGqai----esEk----IVKLFDMKKF--QSNVNRelrraypdrrrle 159  Anopheles ga...
21_pfamImport   77 KRYA-NSNVFVKStalnpq-densigTDILKLQNqal----ekGe----TYKLFDMRKF--HHNMNAefrrsypdrqrle 144 
4R9P_A         133 RRYA-KSNVYVKSTaSSPNE-ETSIGAEILKLPN-Q-------AlesekIVKLFDMKKF--QSNVNRel----------- 189 
1KHX_A         157 --SvnqGFEAVYQLTRMCTIRMSFVKGwgaeyR-RQTVTSTPCWIELHLN 203 
XP_011664649   804 klS---------------IVSLSFVKD-------KVEDFNTPCWISLVVL 831  purple sea urchin
CAP33708       195 lkT---------------CMRIALVKV-----GdGADMNRTPCWFAIVNL 224  Caenorhabditis briggsae
XP_025016728   237 nqC---------------ITCISVDIE-------SDNLLETPCWMMVINI 264  two-spotted spider mite
XP_015789242   278 sqC---------------ITAIAFGKE-----SgTLDLLETPSWIMIINI 307  two-spotted spider mite
XP_015782979   194 nqC---------------INVIAFVKD-------ATDVLDLPVWIMVVNI 221  two-spotted spider mite
EEB17140       171 cqC---------------LSTIVFVKN-------EKEILNCPVWVMIINV 198  human body louse
Q7QJC4         160 tqC---------------LSAIAFVKS-------ENDILDCPMWVLIINV 187  Anopheles gambiae str. PEST
21_pfamImport  145 tqC---------------LSALVFVKQ-------ENDILDCPVWILVINV 172 
4R9P_A         190 ----rrAYPDRRRLETQCLSAVAFVK------S-ENDILECPIWVLIVNV 228 
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