6SNH


Conserved Protein Domain Family
Alg6_Alg8

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pfam03155: Alg6_Alg8 
ALG6, ALG8 glycosyltransferase family
N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid (dolichol phosphate)-linked oligosaccharide is assembled at the endoplasmic reticulum membrane prior to the transfer of the oligosaccharide moiety to the target asparagine residues. This oligosaccharide is composed of Glc(3)Man(9)GlcNAc(2). The addition of the three glucose residues is the final series of steps in the synthesis of the oligosaccharide precursor. Alg6 transfers the first glucose residue, and Alg8 transfers the second one. In the human alg6 gene, a C->T transition, which causes Ala333 to be replaced with Val, has been identified as the cause of a congenital disorder of glycosylation, designated as type Ic OMIM:603147.
Statistics
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PSSM-Id: 397324
Aligned: 211 rows
Threshold Bit Score: 354.872
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SNH_X                         64 AVILRCTIglgpysgkgsPPLYGDFEAQRHWMEITQHLPLSKW----YWYDLQYWGLDYPPLTAFHSYLLGLIG-SFfNP 138
CDS35857                       19 GLCLRSLGilypysgmssPPMFGDYEAQRHWMEITVNLPISEWyvntSSNDLQYWGLDYPPVTAYHSYILGQVS-KLiDP 97  Echinococcus multilocularis...
CCD77290                       19 GIALRSSTslhsysgenkPPMYGDYEAQRHWMEITVNLPFTEWymnsTHNDLNYWGLDYPPLTAYHSWLMGKLA-SKiDR 97  Schistosoma mansoni...
EFX68452                       14 TVIIKLGVslfpysgknnPPMFGDYEAQRHWMEITVNLPIQDWyrntTDNDLLYWGLDYPPLTAYHSYLTGLMA-KKiNP 92  common water flea...
CTP81368                       20 AFTLQIALslgsysghatPPMYGDYEAQRHWMEITYHLPINQWyvngSDNDLNYWGLDYPPLTAYHSWLLGTLA-NKlNR 98  Brugia malayi...
XP_002629983                   37 LICFQIAIslnphsgesqPPMYGDYEAQRHWMEITFNLPIEHWyvngSHNDLLYWGLDYPPLTAYHHNLLGVIT-YKiNK 115 Caenorhabditis briggsae...
Q09226                         56 LLCFQLAIslnphsgesqPPMYGDYEAQRHWMEITVNLPIEQWylngTHNDLLYWGLDYPPITAYHHYLLGVIS-NKiNK 134 Caenorhabditis elegans...
XP_003117425                   56 LLCFQIVIslnphsgesqPPMFGDYEAQRHWMEITLNLPIEQWyvngTLNDLLYWGLDYPPLTAYHHNLLGLIA-YKiNK 134 Caenorhabditis remanei...
WGS:AAGF:cds.TTHERM_00500810A 163 ASFIRILAgigpysgykdAPTYGDYEAQRHWMELTLHTPPSQWyvetLNNDLTYWRIDYPPLSAYVSYIFGYIShQF-DP 241 Tetrahymena thermophila SB210...
A0DD77                         10 SISLRIYVafggysgmndPPQYGDFEAQRHWMELTSHLNITQWyeksEFNDPKWWPLDYPPLSGYFAYALGKVAeKF-DP 88  Paramecium tetraurelia...
6SNH_X                        139 SWFALeKSRGFESPDngLKTYMRSTVIISDILFYFPaViyfTKWLgR------YRNQSp-IGQSIAASAILFQPSLMLID 211
CDS35857                       98 AWTELfISRGLETPE--HKRFMRLTVIVSDCLSYMLaAlsyCAIT-Lkr--lkKDAEL---SGFSVALSMMSFPGLILLD 169 Echinococcus multilocularis...
CCD77290                       98 DWVQLyTSRGFESKE--HKLFMRYTVLVADLLFFIPsIllyFYYV-LpsimnkGNKSQq-IGGFYSACLTLTYPGLILID 173 Schistosoma mansoni...
EFX68452                       93 DYVNLlASRGFESPN--HQFFMRMSVLVSDCLFFISaLyf-yIK-----------NLKmdNKYKWVFFALCSHPGLTLID 158 common water flea...
CTP81368                       99 SWIELhISRGMETET--HKIFMRFTVVATFWIVYVSsLllsTGFF-R------NTLSQ---RMLNYCAIAVLYPGLLVVD 166 Brugia malayi...
XP_002629983                  116 RWVELrDSRGFESVA--HKIFMRVSAIVPFYIFYLPpLiy-aLM------------SSk-KTSPVLYPLSLLYPALLVID 179 Caenorhabditis briggsae...
Q09226                        135 KWVELtTSRGYESIA--HKLFMRLSAIIPFYIFYLPpLif-yFT------------RSk-KMSPILYALALLYPSLLVID 198 Caenorhabditis elegans...
XP_003117425                  135 SWVELtDSRGFESVA--HKMFMRISAIVPFYIFYLPpLif-fYL------------NSk-KTSPMSYALALLYPALLVID 198 Caenorhabditis remanei...
WGS:AAGF:cds.TTHERM_00500810A 242 KSVELyHSRGYEEPN--HKIYMRMTVLISDILFFFTsLyyvTKIE-Fn-----KYSFT---LRSLFYLLALLCPPFILID 310 Tetrahymena thermophila SB210...
A0DD77                         89 EIIAPySSRGIETFN--TKLFMRLSVFISEIIFLYPpLiy-fI-------------LK---QQSKQQLIALCCPLLVLVD 149 Paramecium tetraurelia...
6SNH_X                        212 HGHFQYNSVMLGLTAYAINNLLDEYYAmAAVCFVLSICFKQMALYYAPIFFAYLLSRSLLFPkfn--------------- 276
CDS35857                      170 HGHFQYNCVSLGLFMMSLVFFSEDLDViGSVVFCLAFLYKQMELYHALPIFFFLLSKC-FSHsftv-------------g 235 Echinococcus multilocularis...
CCD77290                      174 HGHFQYNCISLGLYLSGINFLLLEWDMlGSILFCLAIGYKQMELYHALPIFFYLLGRCIYKKsvyr-------------g 240 Schistosoma mansoni...
EFX68452                      159 YGHFQYNSVSLGLALWAIIFVSKGRNLwAAVAFSAALNFKQMELYHAIPMFFYLLASCHRKGstlis------------q 226 common water flea...
CTP81368                      167 SGHFQYNHVSLGLFLFSFACFVSSFLKlGSMFFVLSLSFKQMELYHALPVAIYLLSES-FSSdnrlsmsq-----ryfcw 240 Brugia malayi...
XP_002629983                  180 NGHFQYNSVSLGLFLFAYIFLIQNWTLlGSMFFVAALNYKQMELYHALPVFVFILSRS-INQsqplg------------t 246 Caenorhabditis briggsae...
Q09226                        199 NGHFQYNSISLGLFLATYMFLTKNFTIiGSILFVAALNYKQMELYHALPVFVFILARS-INKtqlfn------------s 265 Caenorhabditis elegans...
XP_003117425                  199 NGHFQYNSISLGMFLATYVFLTNNFTIlGSMFFVAALNYKQMELYHALPIFVFILARS-INKaqpln------------s 265 Caenorhabditis remanei...
WGS:AAGF:cds.TTHERM_00500810A 311 HAHFQYNSFMHGLVLWSVYFCSQGSVViGGILFTLALNFKQMGLYYSLGFFFYILGYLAVDSgfrsiktnkynfgaslff 390 Tetrahymena thermophila SB210...
A0DD77                        150 HGHFQYNCIMLGLTLYAIISLEKGKLVlGSIFYVMALHFKVMSLYYSLPFFIYILSKTyke------------------- 210 Paramecium tetraurelia...
6SNH_X                        277 iarLTVIAFATLATFAIIFAPLy--fLGgglkNIHQCIHRIFPFARGIFEDKVANFWCVTNVFVKYKEr-------FTIQ 347
CDS35857                      236 fkrVAILAATVCTTFLLVFLPFl--tSLd---QLKHVGLRVFPVDRGLFEDKVANFWCISSVLIKWKQi-------FATN 303 Echinococcus multilocularis...
CCD77290                      241 lthLAKLSFVVFLTIFLIFAPFvlttDLs---LLFQVVRRLFPFDRGIYEDKVSNFWCATSPLVKWRSplfmssltLSST 317 Schistosoma mansoni...
EFX68452                      227 lvnLIKIGVVTLATFALIWYPFlq-lhDg---LLQQVLSRVFPFNRGIFEDYVANFWCTLNVLVKIRRi-------LEPT 295 common water flea...
CTP81368                      241 aeqLLILFITVIVTILFVCFPFl--iTRs---DLMQILYRIFPFYRGIFEDKVANFWCSINVFYKLKDn-------FETV 308 Brugia malayi...
XP_002629983                  247 ilkLAKIGVMVLSTFLIIWLPFi---lTe---TAKDVLIRVFPFNRGLYEDKVASFWCAFSFVLKRLP--------IVQN 312 Caenorhabditis briggsae...
Q09226                        266 frrILTIGLFVVGTFLIIWLPFl---lTg---TAKDVIIRVFPFNRGLYEDKVASFWCAFSFILKRLP---------LQS 330 Caenorhabditis elegans...
XP_003117425                  266 vfkIAKIGAVVISTFILIWLPFi---lTg---TAKDVLLRVFPFNRGLYEDKVASFWCAFSFILKRLP---------FQS 330 Caenorhabditis remanei...
WGS:AAGF:cds.TTHERM_00500810A 391 ilrIALVGFGVIATFVLMILPWitd-----kyLLTSLVSAIFPVHRGLYQLKVANFWCFSNIFIKWTQi-------FDQK 458 Tetrahymena thermophila SB210...
A0DD77                        211 pkkVAVVGITVILTTLIIWLPWls--dLk---LIQEAIATIFPIHRGLYQLHVATFWCISHIVIKWNLv-------FNNQ 278 Paramecium tetraurelia...
6SNH_X                        348 QLQLYSLIATVIGFLPAMIMTLLHPKKHLLPYVLIACSMSFFLFSFQVHEKTILIPLLPITLLYsS-TDWnVLSLVSWIN 426
CDS35857                      304 VALYICCLVTLLTSLPACLSLFRRPSISRFILTEAIVSLSFFLFSYQVHEKSVLLVAIPVLCLL-P-IFP---LSSYYFL 378 Echinococcus multilocularis...
CCD77290                      318 KLVWVSAQLVLITCLPSCLVLLKKSKKQKFLVSLALCALNFYLFSFQVHEKSILLVSIPALCLL-P-FYP---ISSFLFS 392 Schistosoma mansoni...
EFX68452                      296 SIASYCLLLTALFSFPCGLHLYFKNSLRNFHLCLINVSLAFFLFSYHVHEKSILLVTLPVSIAS-P-YFP---FTAFWFL 370 common water flea...
CTP81368                      309 FLLRISTIMVLITNIPWSVCLFCHPTMTNFKYCLLASSLSFFLFSFQVHEKSILLVALPAILLW-N-ENP---VLVSWLL 383 Brugia malayi...
XP_002629983                  313 VQIYLSTALVMICSLPSLVSLFLQPSERNFRLSLTTTALSFFLFSFHVHEKTILLATIPALLLL-P-EYP---SLVILFL 387 Caenorhabditis briggsae...
Q09226                        331 VQIYISTALVLAGSAPSLLVLFLRPTEKQFRISLTATGLSFFLFSFHVHEKTILLAAVPALLLI-S-EYT---SLVIWFL 405 Caenorhabditis elegans...
XP_003117425                  331 VQIYLSTALVLLCSLPSLISLFRQPSERNFRLSLVTTSLSFFLFSFHVHEKTILLATIPSLLLI-S-DYP---SSVLWLL 405 Caenorhabditis remanei...
WGS:AAGF:cds.TTHERM_00500810A 459 VIILMSIAFTLVACLPSIYVVFLRPKYKYLKLALFNISMSFFFFSYHVHEKTILIPLVLYVLCI-R-YMN-IYYL--DFV 533 Tetrahymena thermophila SB210...
A0DD77                        279 LLFRLAAILTLLFSIPSLIRLFKQPN--LFRHTLFIVSQTFFLFSFHVHEKTILLPII-LLLIS-QkDYG---YLVYDYT 351 Paramecium tetraurelia...
6SNH_X                        427 NVALFTLWPLLKKDGLHLQYAVSFLLSNWLIG--------NFSFitprflpkSLTpg--psI------------------ 478
CDS35857                      379 FVSTLSMWPLFYKDRLCYVCVALLIIFYAVASiclssdstAKNR--------VSLar----------------------- 427 Echinococcus multilocularis...
CCD77290                      393 LCSTLSMWPLLKKDGLQLASLCLTCIHTILGCfiilksnnGDKH--------VAErkklqnSatsn-------------- 450 Schistosoma mansoni...
EFX68452                      371 SISHFSMLPLYAKDDLILPAVAVLALYCLLANs------------------sLklemgr--------------------- 411 common water flea...
CTP81368                      384 IISNTSLYPLCIKDGNAI-HLALFIFYYIITYs-------------------SFSklsmfmQ------------------ 425 Brugia malayi...
XP_002629983                  388 NISNISIFSLCIKDNFPFA-LVFFFAYFVVSYsvsvynreAKP------------------------------------- 429 Caenorhabditis briggsae...
Q09226                        406 NITNISIFSLCVKDNFALS-LSFFFAYFVVSYayta-------------------------------------------- 440 Caenorhabditis elegans...
XP_003117425                  406 NISNISIFSLCVKDNFPLS-VFLFIGYFLVSYstfpssspLKRL------------------------------------ 448 Caenorhabditis remanei...
WGS:AAGF:cds.TTHERM_00500810A 534 TISCLTLYPLLREDKQTLCWFVLTIVHHFFVRk------------------tLKYleiqgvIkknltdqctlisdskvtd 595 Tetrahymena thermophila SB210...
A0DD77                        352 IIATITHHPLMIEDKLFIEYCVLLVLFFIFTRnnqppqfqDSWI--------LRFyskirnVi----------------- 406 Paramecium tetraurelia...
6SNH_X                        479 -------SSinsDYRRRS-------------------LlpynvvwksfIIGTYIaM-GFYhFLDQFVaPpSKYPDLWVLL 531
CDS35857                      428 -----------------------------------fwP----------LSISLIgYaFIF-ALQFFVqPpVKYPFLFQLF 461 Echinococcus multilocularis...
CCD77290                      451 ----nvtIS----------------------------I----------ILLILIgYsSLI-IGDLLItPpVAYPDLFPLL 487 Schistosoma mansoni...
EFX68452                      412 -------------------------------smqfkcL----------AGISAIgSaVLA-LLFLICpNpPAYPYLWTLL 449 common water flea...
CTP81368                      426 --------L----------------------------V----------VHGSCLaSlALC-LASLLFaPpARFPHIFSLL 458 Brugia malayi...
XP_002629983                  430 -------------------------------------L----------HILSISiGfLIC-ILEMYGpAnQRFPHIYQLA 461 Caenorhabditis briggsae...
Q09226                        441 ---------------------------------prkiS----------HILTILiGfAIC-ILELYGpSnQRFPHIYQLA 476 Caenorhabditis elegans...
XP_003117425                  449 -------------------------------------L----------QIFSVStGfLIC-VLELYGpSnQRFPHIYQLA 480 Caenorhabditis remanei...
WGS:AAGF:cds.TTHERM_00500810A 596 qttqkkiLEqekDIPLIVklisltdlfyksifrkaiyI----------L------SiIAI-IAEKYVkPpTNYPYLFSLI 658 Tetrahymena thermophila SB210...
A0DD77                        407 ------iQF----------------------------Q----------VQIPVLlYvILF-FCQQLIqPpQRFPFLYELS 441 Paramecium tetraurelia...
6SNH_X                        532 NCAvgFiCFSIFWLW 546
CDS35857                      462 INA--Y-SFFHFSGF 473 Echinococcus multilocularis
CCD77290                      488 SSI--Y-SFTLFSLF 499 Schistosoma mansoni
EFX68452                      450 VSV--W-SFAHFSVF 461 common water flea
CTP81368                      459 IAV--Y-CFLHFITF 470 Brugia malayi
XP_002629983                  462 NAF--F-SCLNFLYL 473 Caenorhabditis briggsae
Q09226                        477 NAF--F-SCVHFIYF 488 Caenorhabditis elegans
XP_003117425                  481 NAF--F-SCVHLLYF 492 Caenorhabditis remanei
WGS:AAGF:cds.TTHERM_00500810A 659 YAV--L-GFGLFAYV 670 Tetrahymena thermophila SB210
A0DD77                        442 MQV--L-GFSMYTFM 453 Paramecium tetraurelia
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