2YUJ,1ZC1


Conserved Protein Domain Family
UFD1

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pfam03152: UFD1 
Ubiquitin fusion degradation protein UFD1
Post-translational ubiquitin-protein conjugates are recognized for degradation by the ubiquitin fusion degradation (UFD) pathway. Several proteins involved in this pathway have been identified. This family includes UFD1, a 40kD protein that is essential for vegetative cell viability. The human UFD1 gene is expressed at high levels during embryogenesis, especially in the eyes and in the inner ear primordia and is thought to be important in the determination of ectoderm-derived structures, including neural crest cells. In addition, this gene is deleted in the CATCH-22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate and hypocalcaemia with deletions on chromosome 22) syndrome. This clinical syndrome is associated with a variety of developmental defects, all characterized by microdeletions on 22q11.2. Two such developmental defects are the DiGeorge syndrome OMIM:188400, and the velo-cardio- facial syndrome OMIM:145410. Several of the abnormalities associated with these conditions are thought to be due to defective neural crest cell differentiation.
Statistics
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PSSM-Id: 397321
Aligned: 104 rows
Threshold Bit Score: 147.233
Threshold Setting Gi: 238029490
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2YUJ_A                    16 FSTQYRCFSVSMla-----gPNDRSDVEKGGKIIMPPSALDQLS------RL-NI--TYPMLFKLTNK-NSDR---MTHC 77 
Q22Y58                    98 YSDHLEVYPAYM---------LERHDLEKGNKILLPPSVLNTLS------AS-NL--PYPMIFCVQNTyLNKQ----TYV 155 Tet...
A0CHG3                    12 yvEHLTVHSASS---------YGRPQINNGNKILLPASALQQLI------FI-KQ--NGPMIFKIQST-QSQK---FTYV 69  Par...
A0DT94                     8 yQNMLEVYSAST---------FQKKNLNQGNKILLPASALQQVL------HL-KQ--QGPMIFRLQSTlDDKK---YTYV 66  Par...
WGS:AAFB:cds.EHI_055960A  11 rpieVTCYPFMYmqtpqppqP--------TDKVVFPAYVLDELT------KQ-NPdfQAPILFEVSNKsQTFKk--RIVC 73  Ent...
WGS:AFBI:EDEG_00463       12 pplqwklkPLKF---------PKKDLRNYGGKCILPQIILAELF------EM-EI--PTPYTFEIS----HCGgvfKTNC 69  Edh...
EED44425                  11 fsqewcLKPIKY---------FKDSPNNFSSKISLPMSILNDLT------IQ-NL--PLPYIFEIS----HENgilKTKC 68  Ent...
CAY67413                   1 ---mseeysiyehlepellkDADGNVVKYSDRVALPPSILESLVnqqqrlSIaSL--PHPLIFRLQa--EKSNsavNSFV 73  Kom...
Q8I3L7                    62 ICQKFLTLPLNK---------KSDKLKDHSDKIILPVSILKTLEkg---nYKnEV--EFPYTFSIKNV-QNNY---ITHA 123 Pla...
EDL43983                  61 ICQKFLTLPLSA---------KPDRLNSHSDKVILPVSILKTLEkg---fYRsEV--EFPYTFSLKNV-QNNY---ITHV 122 mal...
2YUJ_A                    78 GVLEFVADEGICYLPHWMMQNLLL---EEGGL--VQVE-SVNLQVATYSKFQPQSPDFL-DITNPKAVLENALR-NFACL 149
Q22Y58                   156 GVLEFIAPEGTCYIPFWMFQMLQC---FDGQQ--IQVTlVTDVKKGKFVKIQPHETAFI-DLPDPRAILEKELR-NYTVL 228 Tet...
A0CHG3                    70 GVLEFVAEEGSCIIPDWLFENMNF---FNRCW--VIVSlEQSLPLGKLIKIQPHETAFI-DLPDPRAILENQLR-NYICL 142 Par...
A0DT94                    67 GVLEFTAEEGTCVVPDWMLESMGF---FDGCN--IIIShEKKLDQGKLIRIQPHETAFI-DLPDPRAILENHLR-NFICL 139 Par...
WGS:AAFB:cds.EHI_055960A  74 GVESF-SSPDFTYFPQWILDYLHI---QPGDV--ATIF-KVLIPKGKSVTFKPLQSTFY-NIEDPKKTLESILR-NYMTL 144 Ent...
WGS:AFBI:EDEG_00463       70 GVLDFTAEDLTITVPEWMYQQLDL---AGTDK--ITLK-IVVLPKGRYVKLLPHSHEFL-DIENPKRELEKTLR-NYQVL 141 Edh...
EED44425                  69 TVGNFTDYEGQVMLPAWMWEHLDL---QTSSF--VQIS-YIRLPLGKKVKLLPHSTDFL-KIDNPRVELETALR-NYGVL 140 Ent...
CAY67413                  74 GVKEFTSQEGTILLPEFIYDKLVS---PDNNDstINITlASDIPKGTSIALKPL--ELYpEIKDWKYFLEAKLIkSYTTL 148 Kom...
Q8I3L7                   124 CVLEFSSNEGIIFVSDNIKENLGLnkpQNSSIarVLIT-YCILSKCDFIKLDSLNNNIN-DIKYMKNLLENELSlNYSTL 201 Pla...
EDL43983                 123 CVLEFSSNEGIIHVSENVKENLGIk--QSSGIvrLLVT-YANIPKCDFIKFESLNENTS-NIKFMKNLLQNELSlNYSTL 198 mal...
2YUJ_A                   150 TTGDVIAINY----NEKI---------YELRVMETKP-DK---AVSIIECDMNVDFDA 190
Q22Y58                   229 HQGDTIHIEF----MKQH---------FQIDILEVKP-ANdynAICVVDAEIEVDFAK 272 Tetrahymena thermophila S...
A0CHG3                   143 TQGETITITF----NKIK---------YMIDIVSVTP-KTdklAVCINEADVEIDFLQ 186 Paramecium tetraurelia
A0DT94                   140 TEGETISINF----HNTN---------YLIDIVKVEP-TNnlkAVCINEADVEIDFMK 183 Paramecium tetraurelia
WGS:AAFB:cds.EHI_055960A 145 TLNTTITFQM-----NTIidgmniatdVSVLISDVQP-FS---SIYIRETELVVEFEE 193 Entamoeba histolytica HM-...
WGS:AFBI:EDEG_00463      142 TQGDEILCNF----EEGN---------MRFTVAEVKPaGL---GVYIVDTDLEVEFLP 183 Edhazardia aedis USNM 41457
EED44425                 141 TIGDEIRLNFihfkN------------MIFSVIEVDP-SYd-nSIYIVDTDLNVEFEE 184 Enterocytozoon bieneusi H348
CAY67413                 149 STNDTVCISE----KDKV---------YKLLVEQAEP-TS---AICLIDTDIDLSIvp 189 Komagataella phaffii GS115
Q8I3L7                   202 TLGDYIHINH-----------------LNFYISELEP-DN---AVSLINTDINVDICE 238 Plasmodium falciparum 3D7
EDL43983                 199 TLGDYVHINN-----------------LSFYISELEP-DN---AVSLINTDITVDICE 235 malaria parasite P. vivax
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