4L3H,3O5C,1IQC,6FU3,3HQ8,4AAO,2VHD


Conserved Protein Domain Family
CCP_MauG

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pfam03150: CCP_MauG 
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Di-haem cytochrome c peroxidase
This is a family of distinct cytochrome c peroxidases (CCPs) that contain two haem groups. Similar to other cytochrome c peroxidases, they reduce hydrogen peroxide to water using c-type haem as an oxidisable substrate. However, since they possess two, instead of one, haem prosthetic groups, bacterial CCPs reduce hydrogen peroxide without the need to generate semi-stable free radicals. The two haem groups have significantly different redox potentials. The high potential (+320 mV) haem feeds electrons from electron shuttle proteins to the low potential (-330 mV) haem, where peroxide is reduced (indeed, the low potential site is known as the peroxidatic site). The CCP protein itself is structured into two domains, each containing one c-type haem group, with a calcium-binding site at the domain interface. This family also includes MauG proteins, whose similarity to di-haem CCP was previously recognized.
Statistics
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PSSM-Id: 397320
Aligned: 491 rows
Threshold Bit Score: 66.7704
Threshold Setting Gi: 81399805
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4L3H_A                  8 DALAALGAQLFVDPALSRNATQSCATCHdpaR---AFTDpregkagLaVSVGDdgqSHGDRNTPTLGYAAL--------V 76  Paraco...
Q1CW97                 59 arAEALGDVLFHDSGLSRCGTVSCASCH---GgegLTVPt-----aK--AKGCd-gHLSERNPPTLLNVAYn-------R 120 Myxoco...
MPITM:COCOR_00177      57 aDAAVLGQRLFEDPGLSRCGTVSCKSCH---AgesYTVEt-----aT--AEGCg-gHQSERNPPSLLNVGYs-------R 118 Corall...
WP_012830123           73 PRAVALGQKLFFDLRVGGDGETGCVTCH---DpetGFQDa-----rDrKSKGa--gGFSRRHALTVLNAAYgdgsyeatP 142 Halian...
Q2SJ93                 59 EEAAELGRKLFFDRSLSGNGQISCAQCH---NpqlYFTDg-----lP-QSQAI---GTTRRSAPSIPGAIYg-------P 119 Hahell...
WP_012286672           57 AAAADLGRALFSDSRLSANGQVSCASCH---QpdhAFTDa-----lP-TGHGV---GTGNRRTMPIAPAVYs-------P 117 Caulob...
jgi:Pnap_4868          65 AEAAALGRALFNDTRLSKNGQVACASCH---AadkQFEDg-----rQ-FGQGI---ATGKRRTMPVMGAAHa-------P 125 Polaro...
ACR29404               87 aDAARLGKRLFADPRLSRNGAVACASCH---LpgdQFQDg-----rP-LALGI---ATGARRTMPVVGATDa-------P 147 Burkho...
WP_014432361           69 pgAIALGERLFFDARFSANGAVSCASCH---MperYFTDg-----rP-FGVGV---GVIPLNTMTLIGAAYs-------P 129 Caldil...
PRJNA194094:J421_5930  65 PRAATLGRALFFDARLSGNGTVSCATCH---VpatDFQDg-----tP-LGHGM---GTTARRTMPVAGTAHg-------A 125 Gemmat...
4L3H_A                 77 pafhrdangkykgGQFWDGRADDLKQQAGQPMLNPVQMAmPDRAAVAARLRdDPAYRTGFEALFGkgvld---------- 146 Paraco...
Q1CW97                121 -------------WFMWDGRADRLWNQAILPLLNPVEMN-ADAQVVRARLTsVESYTTEYQALFGkapad---------- 176 Myxoco...
MPITM:COCOR_00177     119 -------------WFMWDGRADRLWSQAVLPLTNPIEMD-SDATVVRARLAgEPTYTAAYTQLFGkapade--------- 175 Corall...
WP_012830123          143 -------------WQFWDGKADSLWSQALGPPEDAIEMN-SSRTRVALLVY--DEYAAEYQDIFGpfpvalrdaagdpva 206 Halian...
Q2SJ93                120 -------------WQFWDGRSDSLWAQALSPVEDQNEHG-LDRTSAAKIMA--TEYREEYVKLFGdandldavsgltlpa 183 Hahell...
WP_012286672          118 -------------WQFWDGRADSLWSQALGPMENPVEHG-FTRTEVARVLA--AHYRDPYEQLFGsmpdmadhdrfpira 181 Caulob...
jgi:Pnap_4868         126 -------------FLFWDGRKDSAWSQALGPLEDAAEHG-GNRVRLVRLVL--AQYKDPYGKVFGavpevgelpgdaspn 189 Polaro...
ACR29404              148 -------------WLFWDGRKDSLWSQAVGPIENPSEHG-ATRLRAVHVLA--EHYRADYARLFGalpdvsrlprdagpl 211 Burkho...
WP_014432361          130 -------------WFTWDGKADSQWAQALLPLENAVEHG-GNRTLYAHLIA--EHYAAEYEALFGtlpdlshlprnagpv 193 Caldil...
PRJNA194094:J421_5930 126 -------------WFFWDGRADSQWAQALGPLESAVEHG-GSRAQYAHVVA--DHYRREYEAVFGplprlddvpahagpv 189 Gemmat...
4L3H_A                147 ---------------------dperAFDAAAEALAAYQA---TGEfspfdSKYDRVMRGE 182 Paracoccus denitrificans P...
Q1CW97                177 --------------------etdsaLLANVGKVMAAYQRtlvRID-----APFDTDvrrf 211 Myxococcus xanthus DK 1622
MPITM:COCOR_00177     176 --------------------sdpnrLMANVGKVLAAYQRtlnRTD-----APFDADVrrf 210 Corallococcus coralloides ...
WP_012830123          207 pldar-pgtpswqalapatqdaiteVFVGFGKVVAAYERrivSTG-----SRFDEYYRel 260 Haliangium ochraceum
Q2SJ93                184 spkvagvaeknwsqlsaaqqeavnrVFANMGKAIMAYERkleLPP-----ARFDQFIAll 238 Hahella chejuensis KCTC 2396
WP_012286672          182 apggdpaaraawatmtdadrilinrVYANFSKAVAAYERtlkVRP-----SRFDDYLAGv 236 Caulobacter sp. K31
jgi:Pnap_4868         190 gtqa---eraawaalapatrnsvnrVFANMGKAIAAYERlvsYGE-----SRFDRYAQAt 241 Polaromonas naphthalenivor...
ACR29404              212 gtgt---eqaawraldeptragvsrAFANLGKAIAAYEAtlqYAP-----SRFDSYLDGV 263 Burkholderia glumae BGR1
WP_014432361          194 ddpv---aaaaweamtpeeqdainrIFANIGKALAAFQRtllPQP-----ARFDRYVAsl 245 Caldilinea aerophila
PRJNA194094:J421_5930 190 adta---wraawdrlaptrqddvsrVYANVGKAIAAFERrveLPP-----TRFDRYVDDE 241 Gemmatirosa kalamazoonesis
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