1JC7


Conserved Protein Domain Family
NtA

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pfam03146: NtA 
Agrin NtA domain
Agrin is a multidomain heparan sulphate proteoglycan, that is a key organizer for the induction of postsynaptic specialisations at the neuromuscular junction. Binding of agrin to basement membranes requires the amino terminal (NtA) domain. This region mediates high affinity interaction with the coiled-coil domain of laminins. The binding of agrin to laminins via the NtA domain is subject to tissue-specific regulation. The NtA domain-containing form of agrin is expressed in non-neuronal cells or in neurons that project to non-neuronal cell such as motor neurons. The structure of this domain is an OB-fold.
Statistics
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PSSM-Id: 397317
Aligned: 7 rows
Threshold Bit Score: 135.216
Threshold Setting Gi: 1494808598
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1JC7_A          1 CPERELQRREEEANVVLTGTVEEIMNVDPVHhtYSCKVRVWRYLKGKDIvthe-------illdGGNKV-VIG------- 65  
XP_026691468   62 CLDRTTTEKNSTSTVILTGTVQYCDVIRAGS--YKCNIKIWRVMKGNSL---------------AMNLI-TIQkqgilts 123  vase tunicate
EKC34958        1 -----mEIREEMADVVVTGTVKSVSALQRGSklYSAVVEIKRVMKGEDLlges-------svsnAGQEV-LVQ------- 60   Pacific oyster
XP_015785065   42 CRDKVPRKLTDLSNVVLTGFIEQTYPSLDNGeiYSGSVLVKRVFRGPSKf--------------QGNRV-TID------- 99   two-spotted s...
ESN94520       36 CFDLTIEEKVNNAEFIFSGTVREV-RYNVDKkaQKASVEIKRIFKGQHKltqlflseikgrflpIVHKVcTVE------- 107  Helobdella ro...
EEN70054       36 CHEDNLMKRVRRATAIVTGTVEQKMNGYPDGk-YKAKVRVWRVMKGTNEiptanrvqplrdpsrGVAEV-MVD------- 106  Florida lancelet
XP_030843081   38 CQEYPVEKREEIANVVISGYIHRIMR-KPRTimYDCDIEVVRVFKGSEAlysnv------vppmDGNTI-QIG------- 102  purple sea ur...
1JC7_A         66 ----------GFGDPLICDNQVSTGDTRIFFVNPAPqymwpahrNELMLNSSLMRITLRNL 116 
XP_026691468  124 mykkkyvdvyGLGNSAFCKSNVERADTRIFFLNKLN--------NRLVVSASLDRITLKNL 176  vase tunicate
EKC34958       61 ----------GFGDPRFCENTVRVFDTRILMLSLDDg-------GILRLNSSVVRISLRNL 104  Pacific oyster
XP_015785065  100 ----------GLGDASYCQSKGQRGESWIFQLSQISd-------GYFRLNGTLLKLNLDNL 143  two-spotted spider mite
ESN94520      108 ----------GLGLDGLCSSHTRVFDTWLFFTNPVD--------DKLQLNSSLVRLSVMsi 150  Helobdella robusta
EEN70054      107 ----------GFGDPHICDNEVDQGDTRIFLLDKKPag----ppDEFELTSSLIRVTLDNL 153  Florida lancelet
XP_030843081  103 ----------GFGDPAICDNAVTPGETRIFMMNKNGn-------GHLMLNSSVIRITLNNL 146  purple sea urchin
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