Conserved Protein Domain Family
TB2_DP1_HVA22

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pfam03134: TB2_DP1_HVA22 
TB2/DP1, HVA22 family
This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein, which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein, which is thought to be a regulatory protein.
Statistics
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PSSM-Id: 397309
Aligned: 317 rows
Threshold Bit Score: 44.8032
Threshold Setting Gi: 121897431
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008189637         73 PAVATISLtV-----SPpMSRkyervsaatEAlNeKFTYWMTFTAILILESLCrPVLR----LLPLYQMCRTWFFIWCFA 143 pea aphid
WGS:AFBI:EDEG_00410  60 PLKETLTC-Lk----QVkPRA---------SElRhLLIFWLLFGVLTALDAYS-SWLVg---LIPFFYTFKLVFLLWAGP 121 Edhazard...
Q8STK5               58 PLQETLVI-Lr----QVnPKK---------DEaKhMLVFWMVFGILTSLDAYS-GAIIs---FIPLWYTMKFFFLLWAGP 119 Encephal...
EEQ82753             58 PLRETLLV-Lk----QVnPNK---------EEiRhLLIFWLVFGILTSLDAYS-RFIVs---FIPMFYTLKFFLLLYIGP 119 Nosema c...
EOB14563             58 PLKETLLV-Lk----QVnPSK---------DEmKhLLIFWLVFGILTGLDSYS-SCIVr---FIPLFYTMKFVFLLYIGP 119 Nosema b...
XP_011274407         12 PLISTFKS-Lk----TNdINLi--------KS---WLIYWIVFGSLTILEFQFyNLILk---YLPFYSIIKLYLSIWLIL 72  Wickerha...
A0CDJ7               14 PLIQSFKV-L-----KNkDKE---------GQqT-LLKYWCINWMISLLDIVL-EIVLn--dLL--VDIVLVSLAIGLIY 72  Parameci...
11_pfamImport         1 PILQAFKI-Lk----KPtNKK---------LT-Q-SVHYWSVYGSFLIIDWFLtTFFIt--cFIPFYDFFVLVFTIGMAV 62 
XP_002903661        422 PAYVTIGV-L-----GE-KRT---------RRyEwWIAY---FSVAVTVDYLI-TAIGreigWIPLFYHVKLLVMMWLQF 481 Phytopht...
Q5KIV5              144 AAYLSAQV-LdssesSAnDEKv-----------KsLLSFFVVLGCIQTLESLMaGFLEk---rIPQYYTVKLLFLAYLLH 208 Cryptoco...
XP_008189637        144 PIrDNGSAYIYDAII-R---PQ 161 pea aphid
WGS:AFBI:EDEG_00410 122 LK-FNASEVLYDKLIsKipeDY 142 Edhazardia aedis USNM 41457
Q8STK5              120 LK-FRGGIIIYDNILaRipeKW 140 Encephalitozoon cuniculi GB-M1
EEQ82753            120 FR-FKGTKIIYDSLIsKvpeKW 140 Nosema ceranae BRL01
EOB14563            120 YK-FRGGRWLYDNLLcQipeEW 140 Nosema bombycis CQ1
XP_011274407         73 PN-TKGYEFIYFNYI-D---EY 89  Wickerhamomyces ciferrii
A0CDJ7               73 NN-FKFSAAIFNNSI-Q---PF 89  Paramecium tetraurelia
11_pfamImport        63 PQ-LGVAPMLYTKFL-A---PA 79 
XP_002903661        482 PY-FQGAERIFNACF-S---SV 498 Phytophthora infestans T30-4
Q5KIV5              209 PK-TQGAKKIHESVF-R---PL 225 Cryptococcus neoformans
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