Conserved Protein Domain Family
Replicase

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pfam03090: Replicase 
Replicase family
This is a family of bacterial plasmid DNA replication initiator proteins. pfam01051 is a similar family. These RepA proteins exist as monomers and dimers in equilibrium: monomers bind directly to repeated DNA sequences and thus activate replication; dimers repress repA transcription by binding an inversely repeated DNA operator. Dimer dissociation can occur spontaneously or be mediated by Hsp70 chaperones.
Statistics
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PSSM-Id: 397281
Aligned: 13 rows
Threshold Bit Score: 160.587
Threshold Setting Gi: 81478678
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8FLI2                  70 MYRVDSEALGkCEYVQLTNKQYASVLVVDIDLPgDAGGHPVNLpeQVKqkfsqliahylGPAWVGI----NPVNGK--CQ 143 Coryn...
WP_013124642            26 LIRSRARALQ-FPYIQVNPPKLRFWLPFDLDKP-GGAVAWEDA--LLP-----------PPAVAIG----NPHNGH--AH 84  Thiom...
BAN50136                26 KINKKEKAAL-ARHIQPNGPTHKLWLVYDVDRR-DAGLHWEQV--GAP-----------PPNLIAR----NPANGH--AH 84  Pseud...
WP_014293673            29 FIAGAVRAAQ-ARYVQPNGPTHRYWLVFDVDRP-GALLDWDDR--GAP-----------APNIAVI----NHDNHH--GH 87  Ocean...
WP_024100495            32 YRMPRHDALE-RRYLEANPQALSNLLVVDVDHP-DAALRTLSAagNHP-----------LPNAIVE----NPRNGH--AH 92  Rhodo...
Q93MK3                 103 LYRVETDAMRrCQYVVLTHKQRASVVVIDIDRRgHSGGRVEDIdsKVYdklsllaagniSPAWIGV----NPINGK--CQ 176 Coryn...
Q145D4                  28 KVRKKQDAIS-YNYVGLNKP-LTKYIALDLDKGvESTYMFEKK--NLP-----------VPTLIVI----NRETGN--CH 86  Parab...
jgi:Rpic_0441           27 KFRKREKVDQ-FAYCGLNPM-YRSYLSFDLDMP-GSAFRFEDA--HLP-----------PPTIITI----NPENAH--CH 84  Ralst...
jgi:Mmol_0237           27 KFRKREKVQQ-FAYCGLNPM-YRQYLSFDLDEQ-GSAFKFEDV--NLP-----------PPTIITI----NPVNKH--CH 84  Methy...
chanu:ambt_05245        43 TYRYRFSALQkYLHIQVNPINTKCWLIFDLDGT-DPF-IWEDK--LLP-----------PPNIIVSgqgpKAKLQQisAH 107 Alter...
PRJNA52553:THIAE_05965  26 RVLPREYAIK-QPYMQVNQPGLASWLVFDLDHT-NSW-IWEDE--GLP-----------EPNLIVS----NPKNGS--SH 83  Thiom...
Q88BW7                  61 RVRPREYALR-YPYMQVNRPGMVSWLVFDLDHA-NAL-AWDDA--GLP-----------APNLMVR----NRKSGH--SQ 118 Pseud...
WP_013124619            45 RVRPREYAIR-YPYMQVNRPGFVSWLIFDLDHA-KAM-IWEDA--GLP-----------APNLIVR----NRQSGH--SH 102 Thiom...
Q8FLI2                 144 AIWLI-DPVYADASGQSRAMTLLAAATHDLGQWL---GHDSHF-SHRFSRSPFYtgdspTAYRWYRQHHRVYRLADL 215 Coryneba...
WP_013124642            85 LLWGLeAPVATGDAARAAPLRYLAAIEGAMLAKMlphGADPGF-AGLIVKNPAH-----EKWRTHWGPPHLYGLGEL 155 Thiomona...
BAN50136                85 LLYGLhTPIRTAIDGKTAPLRYAGAIDNAMRDLL---NADIGY-SGLICKNPLN-----PHWIVKQWEPELYTLDGL 152 Pseudomo...
WP_014293673            88 LIYGLdVPVRTAPDGKVAPLRYAAAVEAALREKL---DADPGY-GGLICKNPLS-----GHWQVQVWEPRPYDLAWL 155 Oceanimo...
WP_024100495            93 AVWALtEPFTRTEYARRKPLAYAAAVTEGLRRAV---DGDAAY-SGLMTKNPTH-----SAWATHWIHPAPRSLAEL 160 Rhodococ...
Q93MK3                 177 LIWLI-DPVYADSRADSANIRLMKLVTTMLGDHL---GGDAAF-AHRLSRSPFYngddpTAYRWHVQHHRIDRLSHL 248 Coryneba...
Q145D4                  87 YLYGLkKPVSFYKNSRLRPQSYLKQTTLALTHEL---EADIAY-AHTIVKNPNS-----KYWKILENDVY-YDLEDF 153 Paraburk...
jgi:Rpic_0441           85 MLYRLvTPVAFTKNARSGPQDYFGAIQREMERRL---GADTAY-NHTITKNPLN-----PRWKVITHPAAKYHLGDF 152 Ralstoni...
jgi:Mmol_0237           85 YLYHLnTPVAYHESSRSKPQQYFEAVQDAMTHRL---AADTAY-SHTITKNPLH-----TRWQVITNNAS-YDLGDF 151 Methylot...
chanu:ambt_05245       108 LFYAI-QNVPTSRNSRRKPINFLNDIKRKMTSEL---MADNAY-TGPLCKNPLH-----PFWKTSFLHDHEYNLNEL 174 Alteromo...
PRJNA52553:THIAE_05965  84 IFYAI-KPVCTSDNAHLKPIRYMKAVYKAMAKAL---NADPAY-SGPVAKTPFH-----AWWRTAELHTYEYELGDL 150 Thiomicr...
Q88BW7                 119 LFYAV-PSVCTTENARTKPIQYMKAIYAAFAARL---DADVDYhGGPVAKTPGH-----PWWETTEFHSHVYELGEL 186 Pseudomo...
WP_013124619           103 LYYAI-PPVCTTEAARSKPIAYMKAVYEAFAARL---DADTDFhSGPVAKTPGH-----PWWLTHELHAHVYELGEL 170 Thiomona...
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