5YFP


Conserved Protein Domain Family
Exo70

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pfam03081: Exo70 
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Exo70 exocyst complex subunit
The Exo70 protein forms one subunit of the exocyst complex. First discovered in S. cerevisiae, Exo70 and other exocyst proteins have been observed in several other eukaryotes, including humans. In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localized at the tip of the bud, the major site of exocytosis in yeast. Exo70 interacts with the Rho3 GTPase. This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud). In humans, the functions of Exo70 and the exocyst complex are less well characterized: Exo70 is expressed in several tissues and is thought to also be involved in exocytosis.
Statistics
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PSSM-Id: 397277
Aligned: 254 rows
Threshold Bit Score: 133.169
Threshold Setting Gi: 268566853
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YFP_G       239 MNSYTEALLGFIANEKSLVDDLYsqy--teSKPHVLSQILSPLIsayAKLFGaNLKIVRsNL----ENFGFFSFELVESI 312 Saccharomyces c...
XP_002046604 323 YLVMLLGLQRLLNWERAIMRDIIpp----sKHNEVFARLAYNAIelvVKDAEaITQRILrCIsrkeWTSALGIFSALKRV 398 Drosophila virilis
EFX86313     319 fltefTALLRLLQSELRLMLGIVpl----pHQKAVLSIILRDALemiCHDAEsLSGRARrSVsrqeFGPVLLLFPALRHL 394 common water flea
EEB13335     324 ylvTVMALQKLIQNERNLMVGIIpl----qHQSKIFEIIIKSSMdmiVQDGEnIASRAKkCInkhdFAAVLIIFPILKQL 399 human body louse
XP_019698767 353 yllLTAGLHKLMQAERTLVARILpt----sLQAQVLEATVRDAMdlvAHDGDsIATRAKrCIsrrdFSAVLVVFPILKHL 428 Jerdon's jumpin...
EFA08190     326 ylVCVIALHKLMQIEQALIKGIIap----rHQPRVFELIVREAMdtiVQDGEnIVSRAKkCIsrhdFGTVLVVFPILKQL 401 red flour beetle
XP_002406018 287 ylTALTALCKLMQSERTLLQQVLgsadgkePAALPLERVVLPALeatTAEGEaLANRVKrCVarhdFVTVLCLFPVLQHV 366 black-legged tick
XP_015784305 307 yltsVTALYRLMKAELELMEGLMegvipikCQKVIFSRLVQPALdfvVNEGEsIAGRVKkCTakhdFTSALNLFPILRHQ 386 two-spotted spi...
EKC30356     235 yitelSALLKLIQSEAQLMSGIIad----kHHRSVFDNIIQEGLdsvIKNGElLAVNAKkSIakhdFINVLSVFPVLKHL 310 Pacific oyster
XP_557360    318 YLVLLLGLQKLLVWERQLLNDIVpp----sRHNEVFSRLSQPSIemvVKDAEqITSKVMrSIgrkeWSAALGIFSALKHV 393 Anopheles gambi...
5YFP_G       313 NDVKKSLR-GKELq--------nYNLLQDCTQEVRQVTQSLFRDAIDRIIKK---------------ANs---iSTIpSN 365 Saccharomyces c...
XP_002046604 399 ILLQPDIErTYDAa--------qREQLTKVLNKLQQTGAKALEHFLDVVKGEs--------------STnivgqSNVpKD 456 Drosophila virilis
EFX86313     395 VCFKGDCDkLLEGcds-----svRTRFYAMVNNLHTTCGKALEDFAESVRSEs--------------------aAPLpRD 449 common water flea
EEB13335     400 LNMQPEFDkTVQGcdp-----nvQRKYLTILNTLHSTGAKALEDFIESVRNDt--------------------nSQLpKD 454 human body louse
XP_019698767 429 GELKPDLErTVEGcdy-----alRSKFASVLDTLNATGAKALEDFAESVRNEs--------------------gAALpKD 483 Jerdon's jumpin...
EFA08190     402 RSLKPEFErTVEEcdl-----nvKSKFDAILGMLHSTGAKALEDFIESLRSDs--------------------vTQLpSD 456 red flour beetle
XP_002406018 367 RALRRDYDaLLAGptgqp-gtaaAARLPGLAVTLQTTLNKALEELVDSVKSDp--------------------eGKMpRD 425 black-legged tick
XP_015784305 387 ASMRHNFDlLFDGctsdgcstdvQTKFQGLVVTLQTTLNKALEEFIEYIRNDv--------------------dTKVpRD 446 two-spotted spi...
EKC30356     311 RSIKPEFDlTLEGcat-----ptRAKLTSLLSTLGSTAAKALEEFALSIKTD----------------Pe---kASMpKD 366 Pacific oyster
XP_557360    394 QILQPDIDrICDSt--------qKQQLSGVLNRLQQTASKALEQFIESVRNDaggggmvsmtsstisYGg---gSSVpRD 462 Anopheles gambi...
5YFP_G       366 NGVTEATVDTMSRLRKFSEYKNGCLGAMDNITRENWLPSnykekEYTLQNEALNWEDHNVLLSCFISDCIDTLAVNLERK 445 Saccharomyces c...
XP_002046604 457 ATVHELTSNTIWFIEHLYEHFDVIGSILAQDVLYSTQLD-----TILMKKALPGEERNKALLAIYIKKALAELNLSIMNK 531 Drosophila virilis
EFX86313     450 GTVYEMTSNVVLFLGQLTDLSDTVGPLLAQDQSYSNAL--------VHTQPWPKPQRNKALLGLYIKKVLVQLNLTLVTK 521 common water flea
EEB13335     455 GTVHELTSNVLVFLEQLTEYIDTIAGVLLKDPFYSA-----------PLSRINCTNKDKAVIGIYIKKVLAQLNSTLMSK 523 human body louse
XP_019698767 484 GTVAEGTSNVLVFLEQLAEYADTAGAVLRRNTDIDQA----------ISSGKNAGNGYRMILGVYVKKVLAQLNLALVSK 553 Jerdon's jumpin...
EFA08190     457 GTVHELTSNVIMFLEQLLDYTDTIGMVLAQDVSYSR-----------QLDRLKAADTNKALLGLYIKKVLVQLNHTLISK 525 red flour beetle
XP_002406018 426 GTVHELTSNVMVVLEQLLGFVEAAGAVLAVWDLA---------------SFSQSRDPNRAALAQYVTRVLSALNLTLHNK 490 black-legged tick
XP_015784305 447 GTVHELTSNVMIFLVQLSNYLDILSRVITVTDMQ---------------SYERSSDKNKLAFAQFISRVLQTLALNLQLK 511 two-spotted spi...
EKC30356     367 GTVHELTNRTIIFLEPLQDYADTAGAMLLLHGEQAA------------PSEAVDPKKSKMRLADYITKTLSALGLNLTIK 434 Pacific oyster
XP_557360    463 ATVYELTSNTIWFLEQLQEHCDTIGGLLQTEAIYTNDLD-----RIASQKALTMEQKNKALLGIYVRKVLAELNYTIATK 537 Anopheles gambi...
5YFP_G       446 AQIalmpnqepdvanpnssknKHKQRIGFFILMNLTLVEQIVEKS-ELNLML---AGEGHSRLERLKKRYISYM-VSDWR 520 Saccharomyces c...
XP_002046604 532 CEQy-----------------NDQATKHLFRLNNIHYILKSLQRS-NLIDLVtlaEPECEHSYLEMIRELKTSY-QKTWS 592 Drosophila virilis
EFX86313     522 SDAy-----------------SDSSLRYIFRLNNSHYLLSALQRSgLLDLLKv-vEPECEPIYREMINEQKRLY-SQSWN 582 common water flea
EEB13335     524 SDVy-----------------ADVYLRSIFKLNNNHHILKSLQRSeLLDLLKc-sEPECEKNYFDMIQDNKKKY-MQSWG 584 human body louse
XP_019698767 554 SDAs----------------ySDLALRALFRLNNHNYVVNALRRSsLMELLLl-aEPSAEQTYHDLLFKDKNNYvATTFA 616 Jerdon's jumpin...
EFA08190     526 SEQy-----------------SDPALKAIFRLNNNNYVLKSLQRSsLLELYLi-sEPKCEEYYYNSIQEHKKAY-SQSWG 586 red flour beetle
XP_002406018 491 SAKy-----------------EDTALQAVFRLNNLHYVLRALTRSgLLEVVEg-yESSLGQQYLDQIRDQKRLY-SQSWS 551 black-legged tick
XP_015784305 512 SDCy-----------------ADQYLKAIFKLNNIHYILKTLRKSsLSKILEl-yNKEIEKVYEKQIIENKRIY-SQSWS 572 two-spotted spi...
EKC30356     435 AETy-----------------SDPTLRPVFMLNNYHYILKSLKRSgLLDLIHt-wNKDVGQFYEDRINEQKKLY-SESWS 495 Pacific oyster
XP_557360    538 SEQy-----------------SDTATKQLFKLNNTHYILKSLQRSsLIEIVAl-tEHDCERRYQKMIQDLKKAY-LGSWS 598 Anopheles gambi...
5YFP_G       521 DLTANLMDSVFid---------ssGKK----SKDKEQIKEKFRKFNEGFEDLVSKTKQYKLSDPSLKVTLKSEIISLVMP 587 Saccharomyces c...
XP_002046604 593 KMLSGIYSLEElp----------kPVAgkvkDKDRSVLKERFSNFNKDFEEACKIQRGISIPDVILREGIKRDNVEHILP 662 Drosophila virilis
EFX86313     583 KVLAPIWNSEDvpasv----llsgRLR----EKDKALIKEKFSTLNKEFEELSREQRGYSVPDVELRESLKRDNKEYILP 654 common water flea
EEB13335     585 KVLSYIWNSEEvsqt------qygKFK----DKDRHVIKEKFAGFNKEIEEISKIQHGYSIPDVELRESLKRDNKELILP 654 human body louse
XP_019698767 617 KARSYLEQSTDe-----------aDLA-------AKTLKEKFLGFTRELEEVAKCQRSYSVPDRRLREELRKELHEAIVP 678 Jerdon's jumpin...
EFA08190     587 KLLNYIWCDDSpvnl-----lhgdKLR----DKDRAVIKEKFAGFNKEIEDIAKVQRGYSIPDVELRESIKRDNKELIIP 657 red flour beetle
XP_002406018 552 RVLHYVLEVDRpls-------psaKLK----DKDRQTIKDKFTGFNRELDELFRVQKAYAVPDVELRESLKRDNKEFVLP 620 black-legged tick
XP_015784305 573 RVLHFIIEIDNkapspesiemanmKLK----EKDRQMIKDKFSGFNKEIEELRRIQKAYAIPDAELRESLKEDNANFIVP 648 two-spotted spi...
EKC30356     496 RVMHYITEVHEpisqqriqamensKLK----DKEKQNIKDKFSGFNKELEDILKIQKGYAIPDPELREQMKKDNKDFIIP 571 Pacific oyster
XP_557360    599 KMLSFIHPLDDmprp------ingKVK----DKERATIKDRFFNFNKELDEAVKIQRAISVPDVLLREGIKRDNTEHIVP 668 Anopheles gambi...
5YFP_G       588 MYERFYSRYK--DSFKNPRKHIKYTPDELTTVLNQ 620 Saccharomyces cerevisiae S288C
XP_002046604 663 NYNRFFEMYAavQFSKNPDKYVKYRPHEINAMLSK 697 Drosophila virilis
EFX86313     655 KYQAFYDKYSnaQFSKHSEKYIKYSPAQISSVIDT 689 common water flea
EEB13335     655 KYNAFYERYSnvNFSKNPEKYIKYTPAQVSALIDR 689 human body louse
XP_019698767 679 LYIAFHTKYRgvSFSKNPGKYIKYTPDQISALINT 713 Jerdon's jumping ant
EFA08190     658 KYNSFYNMYAgvQFTKNPEKYIKHKPDEVSAVIDR 692 red flour beetle
XP_002406018 621 KYKLFYDKYTavPFTKNPDKYLKYSPLDVSNLIDR 655 black-legged tick
XP_015784305 649 RYAQFFNKYSnlSFSKNIEKYVKFTPNEVYNIIQS 683 two-spotted spider mite
EKC30356     572 AFRMFLDKFKrlNFTKNPEKYIKYSVQDVAEVVDK 606 Pacific oyster
XP_557360    669 KYNAFFEGYSdvQFSKNIDKYVKYRPSDVTTMLNS 703 Anopheles gambiae str. PEST
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