Conserved Protein Domain Family
Neprosin

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pfam03080: Neprosin 
Neprosin
Pitcher plants are insectivorous and secrete a digestive fluid into the pitcher. This fluid contains a mixture of enzymes including peptidases. One of these is neprosin, characterized from the pitcher plant Nepenthes ventrata. This peptidase is of unknown catalytic type and is unaffected by standard peptidase inhibitors. Unusually, activity is directed towards prolyl bonds, but unlike most peptidase that cleave after proline, there is no restriction on sequence length or position of the proline residue. The peptidase is secreted and is presumed to possess an N-terminal activation peptide. The neprosin domain corresponds to the mature peptidase. It is not known if other proteins with this domain are peptidases.
Statistics
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PSSM-Id: 397276
Aligned: 163 rows
Threshold Bit Score: 83.0543
Threshold Setting Gi: 81710479
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
RID53770      175 INVWKPHV-QtRREFSLAQIWVM-GGt-Yp-------sRDTIEAGWQVFQRFYGDDKPRFFIYWTAdEYKktG----CYD 240 field mustard
EDR05125      231 LSLWNP-----VGDFSLSQQWYVgGSgaN---------LQTVEGGWVVYPGKFKTKNAVLFIFYTAdNYKtkK----CWN 292 Laccaria bicol...
XP_001882591  218 LNLWSP-----VGDFSLSQQWYVgGSgaS---------LQTAEGGWVVYPQHF-STQAVLFIFWTPdDYt-tG----CYN 277 Laccaria bicol...
EDR02747      220 LNLWSP-----VGDFSISQQWYVgGSgaS---------TQTVEGGWIVYPQKF-SAQAVLFIFYTPdDYs-tG----CYN 279 Laccaria bicol...
jgi:Msil_1094 220 LNLWKPAV-AaSQIFSLSQHWYV-GGngAg--------LQTAETGWQVYPKFYNTPKPVFFIYWTAdGYTntG----CYN 285 Methylocella s...
XP_007818356  143 YSIFKAFV-QrPSDFSLLQVAVI-RNd-Aahag-tppkSQTVEAGWINYPD--QVAAPHLFSFYTTnNYEsyGddvcGWN 216 Metarhizium ro...
XP_007811872  143 ISTHRPFLeR-DGDFSLLQVAV--VHerAdqpngaakqDQTVEAGWTNYPVL-HKGGPILFAFYTTnGYRgqAdyvgGYN 218 Metarhizium ac...
XP_006674769  147 ISMFEPYLqS-QQEFSLVQTAI--VRyeAktve-fgtiPQSLEAGWMYYPP--RGPKPMFFVFFNTnGYHgvGdymcGWN 220 Cordyceps mili...
EJP65112      148 ISMFEPYLaS-QSDFSLIQTAM--VRwyAktte-lgtvTQSLEAGWMYYPP--RGPKPMFFVFFNTnGYQgsSdymcGWN 221 Beauveria bass...
XP_008599615  135 LSMFKAYVaN-NDDFSLLQTAV--ARlnVps-----igTQTVEAGWINYPR--QTANPHLFTFFTTnAYQgyGdyvsGWN 204 Beauveria bass...
RID53770      241 LRCPGFVHVNRDFVIGAPMPkVSVMGg--rQASFLTTIWkdPRTGNWWLRLGY----YQiLGYWPSSLFSn-------lK 307 field mustard
EDR05125      293 LDCAAFVQTNKNWFLGRGFThYSAFGggqwGFEMQWKLV----GGNWWLYLKGpg-aYEaVGYYPTKIFGsg------qL 361 Laccaria bicol...
XP_001882591  278 LECKAFVQISNKWNLGGTFDqYSVTGdgqrGFDLQYKLF----QGNWWLFLRGssanYDaVGYYPGSIYNkg------qL 347 Laccaria bicol...
EDR02747      280 LECKGFVQINNNWQLGGTFGqYSVTGgvqkGVDLQWYFY----QGNWWLYLRGag-aYDaVGYYPGSIYNgg------qL 348 Laccaria bicol...
jgi:Msil_1094 286 LTCAAFVQTNNSWAVGGALKpWSTSPk--kQVVLELSYF--LFQGRWWLYVNGta-aANaIGYYPATLYKgg------aM 354 Methylocella s...
XP_007818356  217 RDVAGWVQYDGEIYPGVAFApLATVGg--dRYEADIGFY--YYRGNWWLHTL-----GRfVGYYPGSLFSrgvd-padtL 286 Metarhizium ro...
XP_007811872  219 FKVKGWFQQDREIYPGMPISaFSVEGgkqeEIEIRYKLF----NNCWWLYTMG----RY-IGCYPTSLFAregvnpkntL 289 Metarhizium ac...
XP_006674769  221 TEQKGWVQVDDSIYPGMSFEhMSVIGgeqhDFDVHFHLS----GGRWWLKAFG----KD-IGYYSADLFSkksk-kedtL 290 Cordyceps mili...
EJP65112      222 TEVKGWVQVDDSIFPGMSFEhMSVIGgeqhDFDVKFHLD----DGKWWLKAFG----KD-IGYYPAELFSkksn-aedtL 291 Beauveria bass...
XP_008599615  205 TEYRGWVQYDAEYYPGMELSpLSVVGgaqhDLQVQYLLE----AGNWWLAVGG----RW-AGYYPAGMFVtrgngaastL 275 Beauveria bass...
RID53770      308 NG-ASEIHWGGEITNYkedSQHTSTNMGSGRFGYEGYKKASYFMNLEi-----------Eed----gVTKPPESLTPFVT 371 field mustard
EDR05125      362 SKsAEVVEYGGEVTRDs--ADHRWPQMGSSIFPSYGFGQSAFQRTIYytardepg------------gvgvwtnLQKLVI 427 Laccaria bicol...
XP_001882591  348 TKnAELVEYGGEVTRFt--TADVWPQMGSGMFPSKGYSQAAFQNTIYynprdesd------------gvgvwsfLTKVVV 413 Laccaria bicol...
EDR02747      349 TKsAQLIEYGGEVLRFt--TAVAWPQMGSGMFPDKGFEQAAYQNAIFysppdvngsaspTvw----------sdLTKAVI 416 Laccaria bicol...
jgi:Msil_1094 355 SVgAQEIDYGGEVVg----TK-SWPPMGSGKFASLGFGKAAYQSDIYyfpp-----agaNvpanltvSQDWPWAY---TG 421 Methylocella s...
XP_007818356  287 DHhSDQINFYGEIYNSe--DEMTTTDMGSGEFPDKGFGYAAYLRKIAy-----------Ydmk--dtfQNYNGSRGVVIS 351 Metarhizium ro...
XP_007811872  290 ATsATNILLYGEVYNTg--ERLTTTDMGTGRHASEGWKYAASMRVMKw-----------Vdtn-gqeHDWS-GFVH--AD 352 Metarhizium ac...
XP_006674769  291 ASyGDRIDFYGEVYNSg--PALTTTDMGSGNFPEAGDGKVGYVKNMVy-----------Ldg-----dgKQQMYSGYTQE 352 Cordyceps mili...
EJP65112      292 AAyGDVINFFGEVYNSg--SELTNTDMGSGNFPEAGDGKVAYVKNMVy-----------Ldg----dgNEQMFTDGYIQE 354 Beauveria bass...
XP_008599615  276 ADhADSVDWYGEIYQSe--GPLTTTDMGSGHFAGEGYAKAAYIRNILi-----------Tgad-drdGDYD-GSKGVIVS 340 Beauveria bass...
RID53770      372 -NQNCYNvIRNPFHPQ--LGASFYYGGP 396 field mustard
EDR05125      428 gSNKCWDiNITQAAQGgsWGTYFFFGGP 455 Laccaria bicolor S238N-H82
XP_001882591  414 gSHSCWDiNITESAQGggWGTFFFFGGP 441 Laccaria bicolor S238N-H82
EDR02747      417 gSRSCWDiNITESAQGgdWGTFFFFGGP 444 Laccaria bicolor S238N-H82
jgi:Msil_1094 422 -SFSYLNs---------pNFSTLFFGGP 439 Methylocella silvestris BL2
XP_007818356  352 -DQSRYNlSAVWNSGSd-WGSYFFIGGP 377 Metarhizium robertsii ARSEF 23
XP_007811872  353 -DPARYSiMPRFQSGWqgWHSHMFLGGP 379 Metarhizium acridum CQMa 102
XP_006674769  353 sDASRYRiKTFFNSGTs-WDSYVYLGGP 379 Cordyceps militaris CM01
EJP65112      355 sDRTRYRiKPFWNSGTt-WKSYIYLGGP 381 Beauveria bassiana ARSEF 2860
XP_008599615  341 -DSNRYSiDTHFRSGTt-WGSYFYLGGP 366 Beauveria bassiana ARSEF 2860
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