2MGY


Conserved Protein Domain Family
TspO_MBR

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pfam03073: TspO_MBR 
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TspO/MBR family
Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates. In, the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.
Statistics
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PSSM-Id: 397274
Aligned: 452 rows
Threshold Bit Score: 35.6227
Threshold Setting Gi: 502628887
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2MGY_A             11 LTLVPSL-GGFMGAY-FVR--GEGlr------wYAGLQKPSWH-PPRWTLAPIWGTLYSAMGYGSYIVWKElggfted-a 78  house mouse
jgi:Glo7428_4030    8 IGGITLL-IALASLf-FRP--RDTq-------wAKNLNRPKWL-VFEPLIPVIWTIVFTGGALSAATVWENapgsfs--t 73  Gloeocapsa...
jgi:Cyan7425_3225   8 IAAITFL-VALGGLl-VRP--RDVy-------wAKRLDRPQWL-FFEPAIPLIWTVVFICGALSAILVWRQapgsfs--t 73  Cyanothece...
WP_015146384        8 IATITLI-VSLGANLfTSP--SDRr-------wFMELRRPRWL-TFEVLIPVIWTLILICGGISAYLIWEEelgsir--g 74  Synechococ...
jgi:Glo7428_0051   28 ILAVSVA-IFFGGNl-LTS--LRDp-------wFQNLTRPGWL-TFESLIPLIWAVVWICGTISAILVWEKsrrqrrdrp 95  Gloeocapsa...
jgi:Nos7107_1020    7 ITAASAA-LFFGGSl-FTS--LRDp-------wFQNLQRPSWL-TFEFLIPVIWTFIWVCITISAIIVWEKsckkgsr-p 73  Nostoc sp....
jgi:Cri9333_0834    7 iTATSAA-IFFGGSf-RTS--LGDp-------wFQNLARPNWL-TFEFLIPFIWIFIWVCVTISAILVWEKssrenk--p 72  Crinalium ...
Q5FTL5             10 AAGTVFG-VQYAARE------ISPaddkatrrwYEHLNKPHFN-PRGPAYAVIWTMLDGLLAWSGYRLLRAekscar--- 78  Gluconobac...
EDV26898            6 LIVLPHL-SGIIAQYlTRNqkKEI---------YACVKRPKWN-PSFWIATLTWAALYTCIGIASYLTWIDgqglqga-a 73  Trichoplax...
EFC50683           48 alvLSLAaVAVAAGIfWFArnKGIks-----kwYKDLEKGKYYfSESLIFN-IWIALYIPLAIGSWLSYVHggqtw---- 117 Naegleria ...
2MGY_A             79 mvplgLYTGQLALNWAWPPIFFGARQMGWALADLLL---VSGVATATTLAWHRVSPPAARLLYPYLAWLAFATVLNYYVW 155 house mouse
jgi:Glo7428_4030   74 wlimgLYLLLEIVTVAYIPATLRSRNLKIGTTLGGSgvvLGVILTFIV---WNISGLAALLLLPYLLWSPVGTYTTWEMM 150 Gloeocapsa...
jgi:Cyan7425_3225  74 wslmgLYLLVEIVTVAYIPATLWLRSLEVGTVLGGLgflLAFVLCLLV---RYLSPEAALLLLPYLLWSPIGTLTTRRMi 150 Cyanothece...
WP_015146384       75 wvimaFYLLLEIMIIAYIPITQRSRNLKLGTWVGLIgfgMGVVLALEV---WQISNWGAILLLPYLTWSPIGSYATWAIA 151 Synechococ...
jgi:Glo7428_0051   96 wffmgLYIAIALLTTLYSPVVVELRSLVGGLIFGGLatiLAYVVAISV---RKISTTASWLLLPYMLWGPIGTYLTWVLI 172 Gloeocapsa...
jgi:Nos7107_1020   74 wglliVYGAIALLTSLYSPVVVELRSLTGGIIVGGLatvLVYILAFVV---KPISPTAAWLFLPYALWGPFGTYLTWLLL 150 Nostoc sp....
jgi:Cri9333_0834   73 wllmiLYAVLGILTAIYSPVVVALKSLMGGLVVGAMatlLVYILAILV---RPILPKASLLLIPYMLWGPIGTYLTWVLI 149 Crinalium ...
Q5FTL5             79 ttaltLWALCVAGVAGFPFFVFRKRQLGTGLAICLG---LIMMSGASIRTAHKVDCKAAAMQVPFFVWLIFATCIHEQIW 155 Gluconobac...
EDV26898           74 kfplcIYALIVLLNLSWQLCYYNIQSLTMAALNLIV---LTGVSGYCAILFLPINEMAFYLVLPYVVWIAFMSLLHITIW 150 Trichoplax...
EFC50683          118 nraltVYALHLVVNVLFSVSLWWVQDLSLALLNLIT---LIGVSMFTTSQFNSILKFAGYINTPYMLWLLIFTAQYAYFW 194 Naegleria ...
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