4AV6


Conserved Protein Domain Family
H_PPase

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pfam03030: H_PPase 
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Inorganic H+ pyrophosphatase
The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists.
Statistics
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PSSM-Id: 397253
Aligned: 287 rows
Threshold Bit Score: 612.123
Threshold Setting Gi: 161161843
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4AV6_A            21 LVALGFAAANFAAVVRKPegtERMKEISSYIRSGADSFLAHETKAIFKVAIVIAILLMIft------------------t 82  Thermotoga ...
jgi:CAP2UW1_3693  77 LGGLVFGAVIYSQIQRLPv-hRSMAEVSELIYETCKTYMLTQGKFLLILEAFTAVIMIGyfyvvqe--------lpvpdv 147 Candidatus ...
Q2IHL0            50 VLGLAFGLVIASQLKALPv-hKSMREISELIYETAKTYLVTQGKFIAILWAFIAVIIVAyfgflttgpdg-grgmgaarv 127 Anaeromyxob...
Q1IQD1            78 ALGLAFGLAIYMTLKNLPv-hRSMLEISELIYETCKTYLTTQGKFILILWAFIAVVIAMyfgwlapvp----nkpiavtl 152 Candidatus ...
Q023J7            79 ALGLIFGLYIFTRLRAMPv-hDSMREVSELIYETCKTYLATQGKFLCILEALIAVIIVFyfgfllg--------fefykv 149 Candidatus ...
BAG14187          61 IFGLFFGLYHFVGIKNLPv-hKSMKSISELIYETCKTYLVTQGKFIFILEVLLAAVIVVyfgllqh--------fgvvkv 131 uncultured ...
WP_012507927      64 LFGMLFGVVQYMGIRKLPv-hNAMREISELIYETCKTYLITQGKFILVLWVLIGAIIVAyfgwlsh--------metikv 134 Pelodictyon...
Q3ARM3            66 LFGILFGFLHYQAIRKLPv-hHSLSEISELIYATCKTYLVTQGKFILVLWALIAAIIVAyfsglrh--------fepvkv 136 Chlorobium ...
jgi:Palpr_0643    58 vgTLSISLYLFKQVKSLPa-hQSMLDVASTIYKTCRTYLLQQGKFLAILFGIIAVAMVYylsmanaeatgpdalstpvvv 136 Paludibacte...
WP_012573230      60 mgTLGFSLLLFKQVKQLPs-hDSMLRVASTIYTTCRTYLFQQGKFLLMLFALVGVVLFIyflgllg--------qsfavv 130 Candidatus ...
4AV6_A            83 wQTGVAFLLGAVMSASAGIVGMKMATRANVRVAEAA-RTtkKIGPALKVAYQGGSVMGLSVGGFALLGLVLVYLIFGKwm 161 Thermotoga ...
jgi:CAP2UW1_3693 148 aMILAFSLVGIAGSFGVAWFGIRINTLANSRTAFASlAA--KPYPVYAIPIKSGISIGMLLISTELLIMLCIMLFVPA-- 223 Candidatus ...
Q2IHL0           128 aLILVMSLIGILGSAGVAWFGIRVNTYANSRSAFAAlGG--KPFPTYAIPLKAGMSIGTMLISVELLIMLAILIFIPS-- 203 Anaeromyxob...
Q1IQD1           153 pVILAFSLVGIAGSYGVAWFGIRVNTFANSRTAFAGlRG--KPYSIYEIPLRAGMSIGMMLISVELLIMLCILLFVPA-- 228 Candidatus ...
Q023J7           150 lIILAFSVVGISGSFMVAAFGMRVNTFANSRTSFAAlRG--KPFPCYAIPLQAGMSIGMLLVSVELLIMLCILLFVPG-- 225 Candidatus ...
BAG14187         132 vTIVLCSVIGILGSCTVAWFGMRINTFANSRTAFASlKG--NPFPLYAIPLRAGMSIGMLLISIELFIMLIILLFIPS-- 207 uncultured ...
WP_012507927     135 vFILVASLIGILGSYTVAWFGMRINTFANSRTAFASlGG--KPFPTYAIPLRAGMSIGMLLISIELFVMLCILLFVPA-- 210 Pelodictyon...
Q3ARM3           137 lFILLASMVGILGSYALAWFGMRINTFANSRTAFASlTG--KPFQLHEIPLRAGMSIGMLLISIELFVMLCILLFVPS-- 212 Chlorobium ...
jgi:Palpr_0643   137 iLVLLFSIVGMAGSYAVAWYGIRINTYANARTAFASlKK--RPWDVVNIPLRSGISVGLFLISLELVMMIIILLFVPR-- 212 Paludibacte...
WP_012573230     131 lQVLLFSIVGMAGSYMVAWYGIRVNTYANARTAFASlRG--RPLDVVNIPLKAGMSVGLFLISLELVLMVIILLFVPR-- 206 Candidatus ...
4AV6_A           162 gqvdnlniytnwlginfVPFAMTVSGYALGCSIIAMFDRVGGGVYTKAADMAADLVgKTELNLPEDDPRNPATIADNVGD 241 Thermotoga ...
jgi:CAP2UW1_3693 224 -----------------ALAGKCFIGFAIGESLGAAALRIAGGIFTKIADIGSDLM-KIEFGIQEDDARNPGVIADCAGD 285 Candidatus ...
Q2IHL0           204 -----------------DLAGPCFIGFAIGESLGASALRIAGGIFTKIADIGSDLM-KIVFKIKEDDARNPGVIADCTGD 265 Anaeromyxob...
Q1IQD1           229 -----------------DYAGPCFIGFAIGESLGAAALRIAGGIFTKIADIGSDLM-KIVFKIKEDDARNPGVIADCTGD 290 Candidatus ...
Q023J7           226 -----------------DLAGSCFIGFAIGESLGAAALRVAGGIFTKIADIGSDLM-KIVFKIKEDDARNPGVIADCTGD 287 Candidatus ...
BAG14187         208 -----------------DFAGACFIGFAIGESLGASVLRIAGGIFTKIADIGSDLM-KIVFNIKEDDARNPGVIADCTGD 269 uncultured ...
WP_012507927     211 -----------------DFAGPCFIGFAIGESLGASVLRIAGGIFTKIADIGSDLM-KIVFKIKEDDARNPGVIADCAGD 272 Pelodictyon...
Q3ARM3           213 -----------------DFAGACFIGFAIGESLGASVLRIAGGIFTKIADIGADLM-KIAFKIPEDDARNPGVIADCVGD 274 Chlorobium ...
jgi:Palpr_0643   213 -----------------SIVGYCFLGFAIGESLGASVLRIAGGIFTKIADIGSDLM-KIVFKVKEDDPRNPGVIADCTGD 274 Paludibacte...
WP_012573230     207 -----------------DIVGICFLGFAIGESLGASALRIAGGIFTKIADIGSDLM-KVVFKVKEDDPRNPGVIADCTGD 268 Candidatus ...
4AV6_A           242 NVGDVAGLGADLLESFVGAIVSSIILasymfpiyvqkigenlvhqvpketIQALISYPIFFALVGLGCSMLGIL--YV-- 317 Thermotoga ...
jgi:CAP2UW1_3693 286 NAGDSVGPTADGFETYGVTGVALISFimlav--------------peaavQVQLLVWLFVMRVMMIVASGISYLgnQMva 351 Candidatus ...
Q2IHL0           266 NAGDSVGPSADGFETYGVTGVALITFillav--------------tdpshQVQLLIWIFAMRIMMIVASVVSYWinEAva 331 Anaeromyxob...
Q1IQD1           291 NAGDSVGPSADGFETYGVTGVALITFillgv--------------hdpkvQVQLLVWIFVMRIMMLVSSAGAYFlnTVia 356 Candidatus ...
Q023J7           288 NAGDSVGPSADGFETYGVTGVALITFillav--------------asptvQVQLLVWIFTMRIMMVISSGVGYFinDAia 353 Candidatus ...
BAG14187         270 NAGDSVGPTADGFETYGVTGVALVTFivlav--------------kepvlQVKLLVWIFVMRLIMLISSALSYGisSAia 335 uncultured ...
WP_012507927     273 NAGDSVGPTADGFETYGVTGVALISFillai--------------kapevQVMLLVWIFAMRLVMILASAVSYWvnAAia 338 Pelodictyon...
Q3ARM3           275 NAGDSVGPTADGFETYGVTGVALISFillai--------------tdpivQVQLLVWIFVMRLVMILASAFSYWlnHGva 340 Chlorobium ...
jgi:Palpr_0643   275 NAGDSVGPTADAFETYGVTGVALISFitlaip------------adqvdlQAKLIVWIFGMRFLMDIFSGISYFvnNAis 342 Paludibacte...
WP_012573230     269 NAGDSVGPTADGFETYGVTGVSLITFialav--------------revdiQAKLIVWIFGMRFLMDFLSGCSFFinQWis 334 Candidatus ...
4AV6_A           318 ---IVkkpsdnpqRELNISLWTSALLTvvLTafLTYfylkdLqgldvlgfrFGAISPWFSAIIGIFSGILIGFWAEYYTS 394 Thermotoga ...
jgi:CAP2UW1_3693 352 rrrYGnkqrfnfeAPLTSLVWITSVVSvvITfiVSYllmgsFaldg-kpysNLWWQLSLIITLGTLAGAIIPEVVKVFTS 430 Candidatus ...
Q2IHL0           332 kakYGdaahmnfeAPLTSLVWLTSAVSvvATfvVSRlliaeLgd------gTLWWKLSAIITCGTLAGAIIPEVIKVFTS 405 Anaeromyxob...
Q1IQD1           357 kgrFGnademnfeTPLTSLVWITSIVSiiLTyiVSKmmipdLsg-----dtTLWWKLATIISCGTLAGAVIPEFVKVFTS 431 Candidatus ...
Q023J7           354 kakYLnadkfdfeAPLTTLVWLTSILSivLTyvLSNmmipdLag-----dtTLWWKLATIISCGTLAGALIPEFVKVFTS 428 Candidatus ...
BAG14187         336 karYAtadkmnfeTPLTFLVWITSIVSitLTfaVSNiiigdLgd------gTLWWKLSLIISCGTIAGAMIPEIVKIFTS 409 uncultured ...
WP_012507927     339 rmrFSnademnfeTPLITLVWLTSVVSivLTyiASWylisnLgd------gTMWWKLASIITCGTIAGALIPELVNRFTS 412 Pelodictyon...
Q3ARM3           341 rlrYGnadvmnfeQPLQSLVVLTSAVSivLTyaASWllissLgd------gSLWWKLASIITCGTLAGALIPELVERFTS 414 Chlorobium ...
jgi:Palpr_0643   343 ekqYGksldfdfeKPLTRLIWIAAISCiaISfgMSYvligdItvgg-kllpHLWWHLATIISFGTLAAVLIPEFTKKFTS 421 Paludibacte...
WP_012573230     335 kklYEnredfdfeSPLMRLIVTSSILCisASffMSHlllgdMkd------tTLWWKLAIIISCGTLAALLIPEFTKLFTS 408 Candidatus ...
4AV6_A           395 YryKPTQFLGK-SSIEGTGMVISNGLSLGMKSVFPPTLTLVLGILFADYF---AG------------------------- 445 Thermotoga ...
jgi:CAP2UW1_3693 431 TnsRHVREVVTaSEAGGASLNILSGIVAGYFSAFWIGVIIVGLMSGAYVVsq-fDltavinpdd-------------aka 496 Candidatus ...
Q2IHL0           406 TssGHVREVVTaSKEGGASLNVLSGLTAGNFSAFWMGLVIIALMGAGYFIst-lGgldvvng----------------gi 468 Anaeromyxob...
Q1IQD1           432 VdsKHVQEVVTsSKEGGASLNILSGLVAGNFSAYWLGLTMVVLMGVGYYVsa-wGaaeghglg---------------al 495 Candidatus ...
Q023J7           429 TnsRHVREIVTsSREGGASLNILSGFVAGNFSAYWLGMAMLALMSIGFFVst-mFpvtlm-------------------- 487 Candidatus ...
BAG14187         410 VksAFVQNVVTsSKHGGASLNVLAGLTAGNFSAYWLGIAVIVLMGIAYAIsl-yGldlim-------------------- 468 uncultured ...
WP_012507927     413 TecAHVRNVVQcTKEGGAALNILAGLVAGNFSAYWMGLAIVGLMGAAYGLst-lGittlgltpeliasqglltvgidkvi 491 Pelodictyon...
Q3ARM3           415 TesSHVRNVVQcSKEGGAPLTILAGLVAGNFSAYWMGLAIVALMGAAYGLse-lGlaslm-------------------- 473 Chlorobium ...
jgi:Palpr_0643   422 SksDHVHEIVTaSREGGPSLTILSGIVSGNYAAYWMGLLMVGLMAGGYFIsqnLGignam-------------------- 481 Paludibacte...
WP_012573230     409 SksTHVKEIVSaSREGGASLNILSGIVAGYFSAFWTGLLIVVLMAAAYFTtl-tGlsetl-------------------- 467 Candidatus ...
4AV6_A           446 -----LYGVAIAALGMLSFVATSVSVDSYGPIADNAGGISEMCELDP-------------------EVRKITDHLDAVGN 501 Thermotoga ...
jgi:CAP2UW1_3693 497 ammaaVFSFGLVAFGFLGMGPVTIAVDSYGPVTDNAQSVYELSMIEQvpgiqaevkrdfgfdldfrSAKFLLEENDGAGN 576 Candidatus ...
Q2IHL0           469 mmapaVFAFGLIAFGFLGMGPVTIAVDSYGPVTDNAQSVYELSLIENvpnvkaevkkdfgfdldfeKAKGYLEENDGAGN 548 Anaeromyxob...
Q1IQD1           496 mlapaVFAFGLVAFGFLGMGPVTIAVDSYGPVTDNAQSVYELSLIENvpnieaelkkdfninvnfeRAKHLLEANDGAGN 575 Candidatus ...
Q023J7           488 -lapaVFAFGLVAFGFLGMGPVTIAVDSYGPVTDNAQSVYELSTIETipniealiqkqygfkpefeKAKENLEENDGAGN 566 Candidatus ...
BAG14187         469 -iapaVFAFGLVAFGFLGMGPVTIAVDSYGPVTDNAQSVYELSLIESipnigkeiekdfgfkpsfsKSKILLEENDGAGN 547 uncultured ...
WP_012507927     492 mlapsVFAFGLVAFGFLSMGPVTIAVDSYGPVTDNAQSVYELSLIENvsakeiese--fgfkpdftNAKRYLEANDGAGN 569 Pelodictyon...
Q3ARM3           474 -lapsVFAFGLVAFGFLSMGPVTIAVDSYGPVTDNAQSVYELSLIEStpnitsdietnygfspdfqHAKHSLEANDGAGN 552 Chlorobium ...
jgi:Palpr_0643   482 sgyesIFAFGLVAFGFLCMGPVTIAVDSYGPVTDNAQSVFELSQIEQipnisaeiekyfgftpdfeRGKHYLEANDSAGN 561 Paludibacte...
WP_012573230     468 gphatIFAFGLVAFGSLCMGPVTIAVDSYGPVTDNAQSIFELSQIEQipnieksiekdygfkpdfkKGKYYLESNDSAGN 547 Candidatus ...
4AV6_A           502 TTAAIGKGFAIGSAIFAALSLFASYMFSqispsdigkppslvlLLNMLDARVIAGALLGAAITYYFSGYLISAVTKAAMK 581 Thermotoga ...
jgi:CAP2UW1_3693 577 TFKATAKPVLIGTAVVGATTMVFSIVMLltagl-----tdnldKLSLLHPPFLLGLIAGGATIFWFSGASTQAVSTGAYR 651 Candidatus ...
Q2IHL0           549 TFKATAKPVLIGTAVVGATTMIFSIIVVltqglk----pelisKLSILNPLFLLGLIMGGAVIYWFSGASTQAVSTGAYR 624 Anaeromyxob...
Q1IQD1           576 TFKATAKPVLIGTAVVGATTMIFSIIMAltngl-----ttdvgKLSLLHAPFVLGLITGGAMIFWFAGASIQAVSTGAYR 650 Candidatus ...
Q023J7           567 TFKATSKPVLIGTAVVGATTMIFSTIVAlthgl-----kdnmdKLSMMHAPFLLGLIAGGAVIYWFTGASAQAVTTGAYQ 641 Candidatus ...
BAG14187         548 TFKATAKPVLIGTAVVGATTMIFSTIVMltdsl-----ttgldKLSLLHAPFLLGLIAGGAVTYWFTGSSNHAVTSGAYK 622 uncultured ...
WP_012507927     570 TFKATAKPVLIGTAVVGSTTMIFSIIMIltngla---dvsaiaKLSILSPPFLLGLMMGGAVIYWFTGASMNAVTTGAYF 646 Pelodictyon...
Q3ARM3           553 TFKATAKPVLIGTAVVGATTMIFSIIMIltnglt---dtaaieKLSILSPPFLLGMLLGGAVIYWFTGASINAVTTGAYY 629 Chlorobium ...
jgi:Palpr_0643   562 TFKATAKPVLIGTAVAGATTMIFSIILLlkgv--------gmlSLELTQAPILLGLITGGAMVFWFSGASIQAVTTGAYR 633 Paludibacte...
WP_012573230     548 TFKATAKPVLIGTAVIGATTMIFSIILLlekv--------gllNLSLTDAPVVLGLICGGAVVFWFSGASMQAVTTGAYR 619 Candidatus ...
4AV6_A           582 MVDEIRRQAREIpglleGk--A--KPDYNRCIEITSDNALKQMGYPAFIAILTPLVTGFLlGAEFVGGVLIGTVLSGAML 657 Thermotoga ...
jgi:CAP2UW1_3693 652 AVEFISTHIRLD-----Ev-vKasQKDSKKVVEICTIYAQKGMFNIFMAVFFGTLACAFI-EPFFFIGYLISLAIIGLYQ 724 Candidatus ...
Q2IHL0           625 AVEFIKQNIRLE-----Gv-eKasVEDSKKVVEICTQYAQKGMFNIFLVVFFATLAFAFA-DEFFFIGYLVSIAIFGLFQ 697 Anaeromyxob...
Q1IQD1           651 AVEFIKANIKLE-----Gi-eKasVADSKKVVAICTQYAQKGMFNIFLAVFFGTLAFAFF-EPFFFIGYLISIAIFGLYE 723 Candidatus ...
Q023J7           642 AVEFIKKNIKLE-----Tt-eKasVADSKKVVEICTKYAQKGMFNIFLVVFFSTLAFAFL-EPFFFIGYLVSIALFGLFQ 714 Candidatus ...
BAG14187         623 AVEFIKNNIKLD-----GssdRasTEDSKKVVEICTKYAQKGMVNLFLVIFFTTLAFAFI-EPYFFIGYLISIALFGLFQ 696 uncultured ...
WP_012507927     647 AVEFIKKNIKLD-----AsveKasIEDSKKVVEICTKFAQKGMINIFLTIFFTTLAFACL-DSFFFIGYLISIALFGLYQ 720 Pelodictyon...
Q3ARM3           630 AVDYIKQHLHLD-----GsaqKasMEESKKVVAICTSYAQKGMVNLFLTIFFSTLAFACL-DAYLFIGYLISIALFGLYQ 703 Chlorobium ...
jgi:Palpr_0643   634 AVEYIKRHMKLDk-------tQadEKDSIEVVRICTQYAQNGMWNIFITLMTATLAFALF-DPNFFVAYLISIAIFGLFQ 705 Paludibacte...
WP_012573230     620 AVMFIKETFNMDk-------kEanIEDSKSVVKICTQYAQKGMWNIFIALMSLTLAFAFI-DANFFVSYLISIAIIGLFQ 691 Candidatus ...
4AV6_A           658 AILTANSGGAWDNAKKYLEagnlegygKGSEPHKALVIGDTVGDPLKDTVGPSLDILIKIMSVVSVIA 725 Thermotoga maritima
jgi:CAP2UW1_3693 725 AVFMANAGGAWDNAKKIVEtem---haKGTDLHNASVVGDTVGDPFKDTASVAMNPIIKFTTLFGLLA 789 Candidatus Accumulibact...
Q2IHL0           698 AIFMANAGGAWDNAKKVVEvel---kaKGTPLHDATVVGDTVGDPFKDTSSVAMNPIIKFTTLFGLLA 762 Anaeromyxobacter dehalo...
Q1IQD1           724 AIFMANAGGAWDNAKKVVEvel---kaKGTPLHDATVVGDTVGDPFKDTSSVAMNPVIKFTTLFGLLA 788 Candidatus Koribacter v...
Q023J7           715 AIFMANAGGAWDNAKKVVEtel---raKGTPLHDACVVGDTVGDPFKDTSSVALNPIIKFTTLFGLLA 779 Candidatus Solibacter u...
BAG14187         697 AIFMANAGGAWDNAKKYVEvdl---reKGTELHKATVVGDTVGDPFKDTSSVAMNPIIKFTTLFGLLA 761 uncultured Termite grou...
WP_012507927     721 AIFMANAGGAWDNAKKLVEtel---naKGTELHDASIVGDTVGDPFKDTSSVALNPIIKFTTLFGLLA 785 Pelodictyon phaeoclathr...
Q3ARM3           704 AIFMANAGGAWDNAKKVIEtem---daKGTPLHDASVVGDTVGDPFKDTASVALNPIIKFTTLFGLLA 768 Chlorobium chlorochroma...
jgi:Palpr_0643   706 ALYMANAGGAWDNAKKLVEvdl---qeKNTPLHDASVIGDTVGDPFKDTTSVALNPIIKFSTLFGLLA 770 Paludibacter propionici...
WP_012573230     692 AIYMANAGGSWDNAKKIVEvel---keKNTPLHEAVVVGDTVGDPFKDTSSVSLNPIIKFSTLFGLLA 756 Candidatus Azobacteroid...
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