4LRH,5F4Q,5JYJ,6HCE


Conserved Protein Domain Family
Folate_rec

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pfam03024: Folate_rec 
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Folate receptor family
This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.
Statistics
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PSSM-Id: 397250
Aligned: 34 rows
Threshold Bit Score: 85.5909
Threshold Setting Gi: 75165110
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4LRH_H        14 VCMNAKHHKEKPGPEDKLHEQ--------CRPWRKN-------------------------------ACCSTNTSQEAHK 54  human
XP_006117388  22 RCLEGETHKPRPSPEPDMHE---------CTLYSES-------------------------------SCCYANFTEQLAH 61  Chinese soft-sh...
Q7T3I8        28 VCLQDGKHKATPSPEPHLTE---------CSLYADN-------------------------------SCCTEEQIQDMSH 67  Nile tilapia
Q5DRQ5        27 AC---GGSHQFQARSQGHLGL--------ASNLGTNqvqlagdlqasgpqpymmiqdpdsqafplpePCCPSEMDTPETS 95  thirteen-lined ...
Q8QZY4        27 AC---GWSHPLQTRSWGHPGL--------AAKVRTGqlqpaghpqssvlpsypriqvpgsqtppvpvPCCTAEIDRPES- 94  house mouse
Q9BSG5        27 AC---GGSRPLQARSQQHHGL--------AADLGKGklh-------------------------lagPCCPSEMDTTETS 70  human
Q4TUC0        27 AC---GGSRPLPALSRRHHRL--------AADLGTG-------------------------------QLHLAEMDTPEAS 64  dog
Q0IHI5        24 KCLPGRTPNLLPEAEANLLQ---------CQQYSEK-------------------------------ACCTQEQINAHP- 62  African clawed ...
Q14DK5        28 QCL--DFRPPFRPPQPLSF----------CAQYSAF-------------------------------GCCTAEQDAALAR 64  house mouse
Q69GM1        38 RCLNGSSPRRVKKRHRKLQTLdlggagegCRGLYPRl------------------------------SCCPKTDIPGMPM 87  African clawed ...
4LRH_H        55 DVSY-LYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPW-IQQvdqsWRKERVLNVP-LCKEDCEQWWEDCRTSYTCK 131 human
XP_006117388  62 SPVIkVSHSSWDRCGELSKSCEEYMKKIECFYRCSPHAAHW-INP----NYTSGIKLVP-LCQNFCDDWYEACKSDLTCV 135 Chinese soft-sh...
Q7T3I8        68 VPSVnNQNEPWDKCGSLSPECEGFLKRVSCFYRCSPDAARW-PHP----QRRSYIQAVP-LCHSFCRDWFDACRMDLTCA 141 Nile tilapia
Q5DRQ5        96 GPGI-----FPPRCRTPSSGCESFLGHLQRALRNRFHLLLLgVRQ-----------APP-LCEELCQNWFATCEADITC- 157 thirteen-lined ...
Q8QZY4        95 ---------LLESCGAPSPECEFFLGQLQGALRDRFHPQLFgARP-----------VQP-LCPELCQIWFTTCQADFIC- 152 house mouse
Q9BSG5        71 GPGN-----HPERCGVPSPECESFLEHLQRALRSRFRLRLLgVRQ-----------AQP-LCEELCQAWFANCEDDITC- 132 human
Q4TUC0        65 GPGM-----VSEHCGKPSPGCESFLGHLQVALHNRFRLLLLgIRQ-----------AQP-LCSELCDIWFATCESDITC- 126 dog
Q0IHI5        63 -----ITSFPWGLCGPLSSSCEKYVSRVQCMYLCSPHISAF-WNQ----DSDTGIYNLP-LCSGFCNQWFEACKEDLICT 131 African clawed ...
Q14DK5        65 RFRVlETRMD----AGVWATCAGYALDLLC-QECSPYAAHL-YDAe---DPATPLRTVPgLCEDYCLDMWQTCRGLFRLL 135 house mouse
Q69GM1        88 DSKI-LS-------VANNTECAKLVEEIRCAH-CSPHAQNL-FHAsersETSERQLFLPvLCKDYCKEFYYTCRGQ---- 153 African clawed ...
4LRH_H       132 snwHKGWN----Wts-gfNKCAVGAAC---QPFHFy-fPTPTVLC--NEIWTHSYKVS--NYSRG--------------- 183 human
XP_006117388 136 hnwLTDWE----WdengeNHC--KNEC---ISYDKv-yANGTDLC--QSMWGDSFKVS-----DS--------------- 183 Chinese soft-sh...
Q7T3I8       142 r----nWA----Rdp-rgQNC--TGNC---VQYQQm-yQHGRDLC--ESLWGDAFMTV--EDEPEevgeageigvdvdgv 202 Nile tilapia
Q5DRQ5       158 ---GRTWL----Wps-gkRSC--EGRC---RTYGQt-fADGVDLC--RSVLGHILPVA----APG--------------- 202 thirteen-lined ...
Q8QZY4       153 ---GPTWL----Qss-geRGC--EPSC---RTYGQt-fANATDLC--HSVLGHVLRVA----APG--------------- 197 house mouse
Q9BSG5       133 ---GPTWL----Pls-ekRGC--EPSC---LTYGQt-fADGTDLC--RSALGHALPVA----APG--------------- 177 human
Q4TUC0       127 ---GPTWL----Pll-ekRGC--EPRC---TTYEQt-fADGADLC--RSVLGYALPVA----APG--------------- 171 dog
Q0IHI5       132 ------------LtnetiPRC--ADAC---VPYKQmfkSEGEDLC--NGIWGDSLVAS-----SE--------------- 172 African clawed ...
Q14DK5       136 spdRELWA----LesnraKLC-------------RylsLDDTDYCfpSLLVNENLNSNlgRVVAD--------------- 183 house mouse
Q69GM1       154 ---IPGLLqtsaDefcfyHGMRDSGLCfpdFPRKQm-rGPASNYL--DQMEDYDKVEEisRKHKH--------------- 212 African clawed ...
4LRH_H       184 -SGRCIQ 189 human
XP_006117388 184 -SCLCLQ 189 Chinese soft-shelled turtle
Q7T3I8       203 rPCGCLT 209 Nile tilapia
Q5DRQ5       203 -SRHCLN 208 thirteen-lined ground squirrel
Q8QZY4       198 -SSHCLN 203 house mouse
Q9BSG5       178 -ARHCFN 183 human
Q4TUC0       172 -ADHCLN 177 dog
Q0IHI5       173 -NCACVN 178 African clawed frog
Q14DK5       184 -AKGCLQ 189 house mouse
Q69GM1       213 -NCYCIQ 218 African clawed frog
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