6CC4


Conserved Protein Domain Family
MVIN

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pfam03023: MVIN 
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MviN-like protein
Deletion of the mviN virulence gene in Salmonella enterica serovar. Typhimurium greatly reduces virulence in a mouse model of typhoid-like disease. Open reading frames encoding homologs of MviN have since been identified in a variety of bacteria, including pathogens and non-pathogens and plant-symbionts. In the nitrogen-fixing symbiont Rhizobium tropici, mviN is required for motility. The MviM protein is predicted to be membrane-associated.
Statistics
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PSSM-Id: 397249
Aligned: 13 rows
Threshold Bit Score: 333.488
Threshold Setting Gi: 7387909
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6CC4_A  131 VARIFGAGMATDAFFVAFKLPNLLRRIFA--EGAFSQAFVPILAEYKsKq------GEDATRVFVSYVSGLLTLALAVVT 202  Escherichia coli
O83529   32 KSTLMGTSATADAFTVAFMIPNLFRRLFA--ENAISVAFIPVFTQHYsMpssaqvpCSSKTKEFLSAIFTLMSSVTASIS 109  Treponema pallidum ...
Q46378   34 MATYFGADPLVASFWLAFRTIFFLRKLLG--GPILGLAFIPHFEFLR-Aq------NISRATFFFRSFSRFFCYSAILFT 104  Chlamydia trachomat...
Q9WXU1   28 LAKTFGASSTLDAYYVSIVFPFFLRRTFA--EGAMSSAFMAIYKKLK---------NKEEKAQFTSAVLTSLGLVTLLIV 96   Thermotoga maritima...
Q55179   36 IAAAFGVGTVVTAYAYAYVIPGFLFILLGgiNGPFHSALVSVLSKRD----------REEAAPLVETVTTLVSGVLLGVT 105  Synechocystis sp. P...
P9WJK3   48 LAAILGAALASS-FSVANQLPNLVAALVL--EATFTAIFVPVLARAE-Qd------DPDGGAAFVRRLVTLATTLLLGAT 117  Mycobacterium tuber...
Q9RX17   83 IN--LFDTTLTDAFNVAIKVPNLMRELLA--EGALVNSFIPVYKTLD----------AAERRKLAQSFSGFLIAINLLLM 148  Deinococcus radiodu...
O51750   29 FSYYFGANLDADIFNYVFNIPNNLRKILS--EGAMTSAFLPEFTHEK-Nk------SHEKAVSFFRTVITFNIISIGLIV 99   Borreliella burgdor...
Q9ZCW4   28 IASLFGSTPMGDSMNIAFKLPNLFRRIFA--EGALSSVFIPIYNEKM-Li------SKKAANNFSGKVFTLLSLTLIVII 98   Rickettsia prowazek...
Q9X8T0  300 IVSALGVGLLGDTFQVAYQLPTMIYILTV--GGGLNSVFVPQLVRAMkD-------DEDGGEAFANRLLTLVMVALGALT 370  Streptomyces coelic...
P44958   16 IAHLIGAGAAADVFLFANRIPNFLRRLFA--EGAFSQAFVPVLAEYQqSg------DMNKTREFIGKVSGTLGGLVSIVT 87   Haemophilus influen...
O67658   29 VAYYFGASAVSDAFFIAFRIPNAFRRIFG--EGGFNAVFIPFYGEAV---------KQNREEEFLRKTFGLLITFSLSVV 97   Aquifex aeolicus VF5
O25551    2 MANILGAGVYSDIFFVAFKLPNLFRRIFA--EGSFSQSFLPSFIRSSi--------KGSFASLVGLIFCIVLFMWCLLVA 71   Helicobacter pylori...
6CC4_A  203 VAGMLAAPWVIMVTAPGFadta-------dkfALTSQLLKITFPYILLISLASLVGAILNTWNRFSIPAFAPTLLNISMI 275  Escherichia coli
O83529  110 LIGILGAPYIVRLFDTDQ--------------SLTVSLTRLMFPYLWMISLAAFFQGMLHSIKVFVPSGCTPIFFNVSVI 175  Treponema pallidum ...
Q46378  105 LI-IELGLCVWCSCVTGSlfd---------tlLLT----IILLPSGIFLMMYTVNSTLLHCEKKFFSVGLAPSVVNVSWI 170  Chlamydia trachomat...
Q9WXU1   97 FLSEVFPYFMASIFATGAdee---------vkSLAADLIRLTAPFITIVFVWAVFYSVHNASHRYFLPALTPMFSNVGVI 167  Thermotoga maritima...
Q55179  106 IILVLGAGIFIDLLAPGLepe---------trRMAVQQLQIMAPMALLSGLIGIGFGTLNAADQYLLPSISPLLSSITVI 176  Synechocystis sp. P...
P9WJK3  118 TLSVLAAPLLVRLMLGTNpqv---------nePLTTAFAYLLLPQVLVYGLSSVFMAILNTRNVFGPPAWAPVVNNVVAI 188  Mycobacterium tuber...
Q9RX17  149 ALGIFAAPWVVGLLTSTHani---------drAIAIYMTQLVMPFLTLISLSAVAMGLLNADEHFRESSFAPVAFNIASI 219  Deinococcus radiodu...
O51750  100 LVMIIFAKPIMYFISYYRge----------nlIFASSVFGYLVLYILLISLSSIFVSVLNSYKIFFIPSFSPIMLSFGII 169  Borreliella burgdor...
Q9ZCW4   99 ALMQIFMPQLILCIAPGFyakk-------ekfELTVFLCRITIPYLIFVSLTALLGGILNSVKKFAAFAFSPIILSVCVI 171  Rickettsia prowazek...
Q9X8T0  371 VITVFAAPLLIRLLSNPVasdp-------aanEVGITFVRYFLPSIFFMGLHVVMGQVLNARGRFGAMMWTPVLNNIVII 443  Streptomyces coelic...
P44958   88 ILAMVGSPHVAALFGMGWftdwmndgpdahkfEQASLLLKITFPYLWFVTFVAFSGAVLNTIGKFGVMSFSPVLLNIAMI 167  Haemophilus influen...
O67658   98 IIGLLFPEEIISVISPGIkek--------etfSYAVEFLKFTILYLPLVSFYAYSMAILLVQGKFFVPSVSQTLFNLGFI 169  Aquifex aeolicus VF5
O25551   72 LN----PLWLAKLLAYGFdee---------tlKLCAPIVAINFWYLLLVFITTFLGALLQYKHSFFASAYSASLLNVCMI 138  Helicobacter pylori...
6CC4_A  276 GFALFAAPYFN-PPVL----------Al---AWAVTVGGVLQLVYQLPHLKKIGML-----------------VLPRINF 324  Escherichia coli
O83529  176 FSMYFLNVSHMnVAIA----------A----AIGVLIGGCAQALFQLIFVYMHGFRft--------------lQSPLKAM 227  Treponema pallidum ...
Q46378  171 GTVFLARNYDPrNRIF----------Gl---AVVLVIGFILEWAVTLPGVMKFLGQ-----------------SKEVPQE 220  Chlamydia trachomat...
Q9WXU1  168 VGCLFGDVRWA---------------A-----AGFTIGGLAALLVLLPFGKFRYRP------------------------ 203  Thermotoga maritima...
Q55179  177 LGLGVAVWQLGqQLNTepy----wllGslllAGGTTAGAVLQWLAQIVPQAKAGMGk----------------LRLRFNF 236  Synechocystis sp. P...
P9WJK3  189 ATLAVYLAVPGeLSVDpvrmgnakllVl---GIGTTAGVFAQTAVLLVAIRREHIS-----------------LRPLWG- 247  Mycobacterium tuber...
Q9RX17  220 IALLLLPNNATw------------------lAFGWLIGGVAQLLVQLPALRRFGLLp-----------------EPRLGG 264  Deinococcus radiodu...
O51750  170 LSIFLFYGRFG---IY----------Sa---VIGVIFGGFLQFLIPFANCLMIGFA-----------------WKPTFYF 216  Borreliella burgdor...
Q9ZCW4  172 IFTLIFGNYIE--STI----------Si---SVSLIIAGILQVVFMFICVKKADLH-----------------FPIIFHT 219  Rickettsia prowazek...
Q9X8T0  444 VTLGLFIWVYGtAETSgmkvtsippeGerllGIGVLLGLIVQSLAMIPYLRETGFR-----------------LRLRFDW 506  Streptomyces coelic...
P44958  168 ATALFLAPQMD-NPDL----------Al---AIGIFLGGLLQFLFQIPFMKQAGLL-----------------VKPKWAW 216  Haemophilus influen...
O67658  170 LSLVILFHTLG---HY----------Sl---ALAVLIGGLFQIIPNTFLLFKEKLL-----------------KIP-KFS 215  Aquifex aeolicus VF5
O25551  139 LALLISKEKTHlEALY----------Yl---SYGVLLGGVAQILLHFYPLVKLGLLnllwkgflsfktknaakKKYRSKR 205  Helicobacter pylori...
6CC4_A  325 HDAGAMRVVKQMGPAILGVSVSQISLIINTIFASF------LASGSVSWMYYADRLMEFPSGVLGVALGTILLPSLSKSF 398  Escherichia coli
O83529  228 HDEGVRRIIALLLPTTVGIATYLLNDLVCTALATS------VEIGVAASVQYSLRIQELLLGIFIVSLSSVVLPDLSFHV 301  Treponema pallidum ...
Q46378  221 RDS-IRALIAPLSLGLLSMGIFQLNLLCDMWLARY------INEVGPLYLMYSVRIQQLPVHLFGLGVFTVLLPAISRCV 293  Chlamydia trachomat...
Q9WXU1  204 TFKGLGEFYRLFFGTFMTMAVSQVTTLIDVNVASF------LDPGSLSLIQLSSRLYQLPLGIFGVAVSTVALSTLSESE 277  Thermotoga maritima...
Q55179  237 ALPGVKEVLQVMIPATLSSGMLYINFATNLFFAS-------FIPNAAAAMRYGNFVALTPLGIISNMILVPFLPVFSRLA 309  Synechocystis sp. P...
P9WJK3  248 IDQRLKRFGAMAAAMVLYVLISQLGLVVGNRIAST------AAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA 321  Mycobacterium tuber...
Q9RX17  265 HPALGRVLKQMAPFTLTAGARQFLNLYVTRLLTDAs----qFKPGTQTGYANAEALFTMANGLFVVSPALAVFPRFSQHA 340  Deinococcus radiodu...
O51750  217 REKVFLNFLTRWLRMIFGFSISIITQQISFALAST------LEIGSVSILSNAVVYYQLPVGIFYISIATVIFPKMAEHA 290  Borreliella burgdor...
Q9ZCW4  220 NDPDVKKLLINMGPATISSGVQQLNLFISQSISS-------FIEGAISILAYADRIYQFPLSIIGTSFSTILLPEMSKVY 292  Rickettsia prowazek...
Q9X8T0  507 RGHGLGKAITLAKWTVLFVLANQAGAMIVIQLSTAagkaspVDGTGFAAYANAQLIWGLPQAIITVSLMAALLPRISRSA 586  Streptomyces coelic...
P44958  217 RDEGVTKIRKLMIPALFGVSVSQINLLLDTVIASF------LMTGSISWLYYSDRLLEFPLGLFGIAISTVILPTLARHH 290  Haemophilus influen...
O67658  216 LDREIKTFLKKFLFTLGGFSANQLSLFVDTFLASF------LKVGSISYVYYAARIYLLPISLFSISLSNTLLALVS-TK 288  Aquifex aeolicus VF5
O25551  206 IKRDLKGFFKQFLPSVLGNSSAQIASFLDTTIASF------LASGSVSYLYYANRVFQLPLALFAIAISTALFPSIAIAL 279  Helicobacter pylori...
6CC4_A  399 ASGNHD------EYNRLMDWGLRLCFLLALPSAVALGILSGPLTVSLFqyGKFTAFDALMTQRALIAYSVGLIGLIVVKV 472  Escherichia coli
O83529  302 MRKDWQ------SFEDLLITAIKIVMLITIPATFFVLFSSDRIITLVYknAIFNELSVRMTATIFRWHSVGMLAIALNRV 375  Treponema pallidum ...
Q46378  294 QDQEHQ------QGYDLLRFSLKLTVAVMVVMTMGLLLFALPGVRVLYehGVFPKTAVHAIVEVLRGYSGSIIPMALAPL 367  Chlamydia trachomat...
Q9WXU1  278 GDFHEN-----------LKDFISKSLFLTLPSSIGLMALSERIISLLFgyGAFTHEDVKKSAQILFMYAIGLCFVSLFNL 346  Thermotoga maritima...
Q55179  310 DPQDWP------ELKLRIRQGIMLSALTMFPLTAILVGLAIPIVQVIYerGAFDAEAAAEVAPVLAAYGLGMFFYLGRDV 383  Synechocystis sp. P...
P9WJK3  322 AADDTP------AVLADLSLATRLTMITLIPTVAFMTVGGPAIGSALFayGNFGDVDAGYLGAAIALSAFTLIPYALVLL 395  Mycobacterium tuber...
Q9RX17  341 AEGNWN------EFRSLTAQTIRTSTFLAAPVSALLLVLAPYAVSVYNlkSGFDPNRFEAGSGILAGWALALIPWALVTI 414  Deinococcus radiodu...
O51750  291 VLGNNI------KLNALLVDGIKILLLIFIPVSFLMFIWSDYILNLFLmgGKFSIYDTQKTASVLKCFLLGLLFYSMFGF 364  Borreliella burgdor...
Q9ZCW4  293 KSNDIV------SAQKIQNNAIRIGLLLSLPATFGIIILSHPITNIIYerGVFTPQDTTNTAEAISAFALGLPAFILAKI 366  Rickettsia prowazek...
Q9X8T0  587 SEEDGG------AVRDDISQGLRTTAVAIVPVSFGFVALGIPMCTLMF--GSSGTSEATNMGYMLMAFGLGLIPYSVQYV 658  Streptomyces coelic...
P44958  291 VNREGDsaksavDFRNTMDWGVRMIFLLGVPAAIGIAVLAQPMLLTLFmrGNFMLNDVYAASYSLRAFNAGLLSFMLIKI 370  Haemophilus influen...
O67658  289 KDKEKD-----------TDTALKLTLMLSIPSSFGLFFLSREIVSVLYkrGNFSEEDLFYTSGLLSLYAFSVPFYSLQHI 357  Aquifex aeolicus VF5
O25551  280 KNNQQD------LILQRLQKAWFFLVGVLLLCSIGGIMLSKEITELLFerGQFSPKDTLITSQVFSLYLLGLLPFGLTKL 353  Helicobacter pylori...
6CC4_A  473 LAPGFYSRQDIKTPVKIAIVTLILTQLMN-----LAFIGPLKHAGLSLSIGLAACLNASLLYWQLRKQKI--------FT 539  Escherichia coli
O83529  376 LISAFYAQHNSFAPMIAGTISFVTNIILA-----TLLFIPLGGKGIAFSLSAASMVQTVFLWMFLKRSWQ--------IT 442  Treponema pallidum ...
Q46378  368 VSALFYARRNYKVPMLVGIIAAVVNMVLNv----IGCLVCKQVAVLAYATSLVSWGQLAMLWYCAGKSLP--------TY 435  Chlamydia trachomat...
Q9WXU1  347 LSRAYHASKEVKTPFFATLLVSAVNISLD-----VILGFTMGASGIALATSVSYIAGFVFLTLRMKPS-----------F 410  Thermotoga maritima...
Q55179  384 LVRVFYALGDGNSPFKVSLFNIFLNGLLD-----YLFYKPFGTVGIVMATVGVNLFSMTIFIWMLNRRLA--------GL 450  Synechocystis sp. P...
P9WJK3  396 QLRVFYAREQPWTPITIIVVITGVKILGSllaphITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRpdggqligVG 475  Mycobacterium tuber...
Q9RX17  415 LLRTFYARERTREAVTVSAIGFVLEVGLY-----RLLVPAFGLFGFGLSTTLSG-ILMAFALMLMYQRAL--------GF 480  Deinococcus radiodu...
O51750  365 FQKYYFSIRDAKTPFYLSVLFSILDIAIS-----VFGINYYGLNALALAQSISFMICVIVFYFIILKRGV--------KI 431  Borreliella burgdor...
Q9ZCW4  367 LTPIFYANGDTKTPLKITLFSIIINTNMN-----LLLMDSLKHIGIAVGTSIAAWYNLGLLYSYSTKQHK--------LH 433  Rickettsia prowazek...
Q9X8T0  659 VLRAFYAYEDTRTPFYNTVIVAVVNAAASgl-cyLLLPSRWAVVGMAASYGLAYVIGVGIAWRRLRKRLGg------dLD 731  Streptomyces coelic...
P44958  371 LANGYYARQDTKTPVKIGIIAMVSNMGFN------LLAIPFSYVGLAIASAMSATLNAYLLYRGLAKADV--------YH 436  Haemophilus influen...
O67658  358 LKTVYYSKKNVEIPTKSAFLSVFLEALFGs---vFIFLLNFGVYSFPLAALISSSSVLVYLYQKLPQKVS--------IP 426  Aquifex aeolicus VF5
O25551  354 FSLWLYAKLEQKKAAKISLISLFLGLAAS-----LSLMPLLGVLGLALANSLSG----LFLFVLTIKAFG--------FQ 416  Helicobacter pylori...
6CC4_A  540 PQPGWMAFLLR--LVVAVLVMSGVLLGMLHIMP-EWSLGTMPWR-LL 582  Escherichia coli
O83529  443 IPSLYKTSLYYgvKITLFSVIALVPTWASSFFTaYFFPGSHKIIsHG 489  Treponema pallidum subsp. pallidum str. Nichols
Q46378  436 KGLMWRTFKESgkTVITTILAAVITIGVNIVTHtTYVVFIEPLTvPT 482  Chlamydia trachomatis D/UW-3/CX
Q9WXU1  411 DKKIFKISLAS-------AVMGTVILLLRGSFKgNLGTIFLVLIgVF 450  Thermotoga maritima MSB8
Q55179  451 SLGGWAMDLGK--LVGVTAIASVAGWQGSVLWQrLWGVNSLVENiLE 495  Synechocystis sp. PCC 6803 substr. Kazusa
P9WJK3  476 EARTVLVTVAAslLAGLLAHVADRLLGLSELTAhAGSVGSLLRLsVl 522  Mycobacterium tuberculosis H37Rv
Q9RX17  481 PWQAVGDHLAR---VVPLALLSGIVAWLISRVMp--APGFFLPGlFG 522  Deinococcus radiodurans
O51750  432 DLIEILFVLLK---SIITLFPLYAIYFFFEKFQ--WDVGFSFKNlYF 473  Borreliella burgdorferi B31
Q9ZCW4  434 IEAGIKLFCAK--ILLCCTLMSIIIALIKHYYL-EYLYSEYLLIkVS 477  Rickettsia prowazekii str. Madrid E
Q9X8T0  732 GARVLRTYARLciASVPAALIGGAACYAISRSLgQGVVGSLAALlAG 778  Streptomyces coelicolor
P44958  437 FSRKSAVFFVKv-LLAAIAMGAAVWYYVPEINQ--WAKMDFFMR-VY 479  Haemophilus influenzae Rd KW20
O67658  427 FGNLIKYLIAS-------SFMGGLVYLTESLTQnPFILVSFIPIyAL 466  Aquifex aeolicus VF5
O25551  417 LFLGIIKNLKS--WLVILFLACVEILLLLAFKS--WVTHLYLFYyFq 459  Helicobacter pylori 26695
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