Conserved Protein Domain Family
PFEMP
?
pfam03011: PFEMP 
PFEMP1 DBL domain
PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
Links
?
Statistics
?
PSSM-Id: 281064
Aligned: 11 rows
Threshold Bit Score: 134.547
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
O96296  659 FFYFWIGRFLNDSMYWR-GKVNSCINNPKR-KKc-RNE--CKDDCGCFKEWIGKKKEEWENIKKHFKTQEAFKNkREnsg 733  Plasmodium falcipar...
O96108  594 FFYGSIIDMLNESIEWR-ERLKSCINDAKLgKC--RKG--CKNPCECYKRWVEKKKDEWDKIKEFFRKQKDLLK-DIa-- 665  Plasmodium falcipar...
Q9U0G6  661 FFYYWVAHMLKDSIYWRtKKLDKCLQNGNk-KCg-KKI--CNGDCECFQRWVEKKKTEWTNIKDHFVKQKGIPEgCYft- 735  Plasmodium falcipar...
Q9U0G5  675 FFNFWVAHMLKDSIHWRtKKIKGCLKNGKAiKCt-DK---CKGDCKCFERWVEQKREEWTNIKEHFGKQTDIPTgLT--- 747  Plasmodium falcipar...
O97312  590 FFWSWVSRMLNDSIKWR-NQHSKCINNKKEt----KCIegCKKTCECFEKWVGQKKTEWRKIKHHFDQQENLKG-RDr-- 661  Plasmodium falcipar...
O97324  586 LFWRWVTEMLKDSIDWR-KEYKNCINNGDk-STc-KNV--CKKPCDCFQKWGVRKTKEWQQVKAHYEKEDFGKG-LTp-- 657  Plasmodium falcipar...
O97324 1459 LFKRWLEYFFEDYNRIQ-KKLKPCIENGKGkEQ--KCFkgCKENCDCVKKWVEEKEKEWPKIRKRYLEQYKNAGg----- 1530 Plasmodium falcipar...
O96296 1525 LLKRWLEYFLEDYNKIK-HKISHCTKNGKG-SKc-IKG--C------VDKWVQQKKEEWKQIKERFNEQYKSKT------ 1587 Plasmodium falcipar...
Q9U0G5 1554 LVTHWVQNFLEDYKKIK-HKISHCTKTDQGs----TCQnkCQNKCKCVGEWIKLKQQEWEEIKKRFLNQYKMDS------ 1622 Plasmodium falcipar...
Q9U0G6 1479 LVTHWVQNFLDDYKKIK-HKISHCTKTDQGs----TCQnkCQNKCKCVGEWIPKKREEWQQIKDRFLKQYKNDK------ 1547 Plasmodium falcipar...
O97312 1471 LIKRWLEYFLEDYNKIK-KKLKSCTEKGEG--SpcIKE--C------VDTWITEKRKEWKTIKERYVDKYTKE------- 1532 Plasmodium falcipar...

O96296  734 idmfsGLMDSADVVLELALeLEQLfqDIKDGYGDVKELKGIKELLDEekkkkq-aeeavVvvv--adNQKKTTIDKLLQH 810  Plasmodium falcipar...
O96108  666 -----GMDAGELLEFYLEN-IFLE--DMKNANGDPKVIEKFKEILGKe-----------Neev-qdpLKTKKTIDDFLEK 725  Plasmodium falcipar...
Q9U0G6  736 ---tlEGVLQIEFLNe----GSAQdkQNSLDAKEIQHLKQIKKILDEekqknqeetaggCgpgvasdNKKETIMDKLIDY 808  Plasmodium falcipar...
Q9U0G5  748 -----PDALLEGVLe-----KGVLltSIKEAYGDAKETEHIKQLLDEtavagg----------vvvgaKDNTTIDKLLEQ 807  Plasmodium falcipar...
O97312  662 -----NITLKYYLDILFKE-------KIKEAYGDERESKELEEKLNNi----------eGsqqagdtEHSEFAVDVLLKH 719  Plasmodium falcipar...
O97324  658 -----YKTLEWVLDLSYFP-------IIKEAHPKEKPVQKMEEIIKK------------NqenisrvTKQNNSITKFLQQ 713  Plasmodium falcipar...
O97324 1531 --------SDDYK-VKSFLeDPQFynEVNKAVKPCDDLNAFERSIHCngpns---sqkkD-------VERRDVVVCLLDK 1591 Plasmodium falcipar...
O96296 1588 --------SDEYFNVKSFLeTWIPkiAVVNDQDN---VIKLSKFGNScgcsa--saistN-------GNEEDAIDCMIKK 1647 Plasmodium falcipar...
Q9U0G5 1623 --------DEYYP-VRSVLeTFLVqiGAANANNDVKKLIKLSEFYKScgcsa--ktnseN-------NKNEDAIDCMLDK 1684 Plasmodium falcipar...
Q9U0G6 1548 --------LDEDFNLRSCLeTFLVqiGAAYGEDKFKKVIKLSVFDQScgcsaiassqkkN-------GEYKDAIECMLKK 1612 Plasmodium falcipar...
O97312 1533 --------NDGSNDLTTFLqQGPFysLVEEAKKVVKCKDEQEKLWGCtgnttg-haqdkC--------ENGDFITNLISK 1595 Plasmodium falcipar...

O96296  811 EGDDANNCLKTHKEKC 826  Plasmodium falciparum 3D7
O96108  726 ELNEAKNCVEKNPDNE 741  Plasmodium falciparum 3D7
Q9U0G6  809 EKKIATECIEKHKCPD 824  Plasmodium falciparum 3D7
Q9U0G5  808 ELKDANRCKNCEQRKP 823  Plasmodium falciparum 3D7
O97312  720 EEEIAENCIKYNPEDT 735  Plasmodium falciparum 3D7
O97324  714 ELQEANNCLQKRKQDC 729  Plasmodium falciparum 3D7
O97324 1592 LEKEAKKCEQKHQNSG 1607 Plasmodium falciparum 3D7
O96296 1648 LEKKIDECKRKPGENS 1663 Plasmodium falciparum 3D7
Q9U0G5 1685 LGKKAEKCHDQHSDNP 1700 Plasmodium falciparum 3D7
Q9U0G6 1613 LEEKANKCKEDHSSGE 1628 Plasmodium falciparum 3D7
O97312 1596 LQEKISECTSQSSGSD 1611 Plasmodium falciparum 3D7
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap