1T8Q,5T91,1O1Z


Conserved Protein Domain Family
GDPD
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pfam03009: GDPD 
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Glycerophosphoryl diester phosphodiesterase family
E. coli has two sequence related isozymes of glycerophosphoryl diester phosphodiesterase (GDPD) - periplasmic and cytosolic. This family also includes agrocinopine synthase, the similarity to GDPD has been noted. This family appears to have weak but not significant matches to mammalian phospholipase C pfam00388, which suggests that this family may adopt a TIM barrel fold.
Links
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Statistics
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PSSM-Id: 397241
Aligned: 30 rows
Threshold Bit Score: 134.835
Threshold Setting Gi: 74578717
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1T8Q_C  14 HRGASGYLP-EHTLPAKAXAYAQGADYLEQDLVXTKDDNLVVLHDHYLDRVTDVADrfpdrarkdgryYAIDFTLDEIKS 92  Escherichia coli
P9WMU3  17 HRGASAARP-EHTLAAYDLALKEGADGVECDVRLTRDGHLVCVHDRRLDRTSTGAG------------LVSTMTLAQLRE 83  Mycobacterium tubercu...
P10908  12 HRGGGKLAP-ENTLASIDVGAKYGHKMIEFDAKLSKDGEIFLLHDDNLERTSNGWG------------VAGELNWQDLLR 78  Escherichia coli K-12
O02322  73 HRGSAHDNIpENSLEAFSAVKSEGGQLAEMDIQITMDGVPVICHDSNTVRVTGVDK------------EISAMNITEFRK 140 Caenorhabditis elegans
Q9UAW8  68 HRGAPKSFP-ENSMAGFAQAKADGADLIEFDVALTKDGKAVLMHDDDLDRTTDMKG------------PIRDKTRAELDR 134 Caenorhabditis elegans
O14169  37 HRGYKAKYP-ENTILAFQQAVKAGADCVETDVRLTKDEVVCILHDRNLNRVFGVDV------------DVRDLDYELDNg 103 Schizosaccharomyces p...
Q08959   7 HRAFKARYP-ENTLLAFEKAYAAGADVIETDLQMTSDGMVVVNHDSDTGRMWDKNL------------VIGESTWEEVKR 73  Saccharomyces cerevis...
1O1Z_A  18 HRGYSAKYL-ENTLEAFMKAIEAGANGVELDVRLSKDGKVVVSHDEDLKRLFGLDV------------KIRDATVSELKE 84  Thermotoga maritima
Q9RSP0  37 HQGGEALWP-SNTLTAYRGAVALGVDLLEMDLHATRDGALVLSHDATLDRLTDTQG------------RIADLTLEQVLR 103 Deinococcus radiodurans
O07244  14 HRGFTSFRLpMNSMGAFQEAAKLGFRYIETDVRATRDGVAVILHDRRLAPGVGLSG------------AVDRLDWRDVRK 81  Mycobacterium tubercu...

1T8Q_C  93 LKftegfdIeNGKKVQTYPGRFPxgks-dfrVHTFEEEIEFv--------QGLNHSTGKNIGIYPEIKAPWFHh-QEGKD 162 Escherichia coli
P9WMU3  84 LE------YgAWH-DSWRPDGSHgd----tsLLTLDALVSLvl------dWHRPVKIFVETKHPVRYGSLVE----NKLL 142 Mycobacterium tubercu...
P10908  79 VD------AgSWYSKMFKGEPL----------PLLSQVAERc--------REHGMMANIEIKPTTGTGPLTG---KMVAL 131 Escherichia coli K-12
O02322 141 LRf-----IgTNVSLPTFEEAVA---------HCVANNIMMi--------WDVKNVDENLLKQFVIQIRTYN---LYSKV 195 Caenorhabditis elegans
Q9UAW8 135 CD------IsATFKRTAPGDHCRlatvsrerVPDMEDVVKWavenntrmlFDVKDSDNELVDQIANLFQKYN---LYDKA 205 Caenorhabditis elegans
O14169 104 ----------HFRTIQEPHEPL----------PTYEQFLHEl-------tKHPGVNLLVDIKPVNDLLIIPR----MVDA 152 Schizosaccharomyces p...
Q08959  74 LR--------CKEDGSLAMMTLK---------EILTWAVCH---------PGAKLMLDIKFTNEKIIMIKTFVimLEVKN 127 Saccharomyces cerevis...
1O1Z_A  85 LT--------DG-------KIT-----------TLKEVFEN---------VSDDKIINIEIKEREAADAVLEI---SKKR 126 Thermotoga maritima
Q9RSP0 104 ADagytltPaGGSGFPFRGQGVQ--------VAQLKDVLR----------EFPNTPLIIELKQASPSIAAPFCa-ELRRA 164 Deinococcus radiodurans
O07244  82 AQ------LgAGQSIPTLEDLL----------TALPDMR-----------VNIDIKAASAIEPTVNVIERCN---AHNRV 131 Mycobacterium tubercu...

1T8Q_C 163 IAAKTLEVLKkygYTGKDDKVYLQCFDADELKRIKNELEpkxgxELNLVQLIAYTDWNETqqkqpdgsWVNYNYDWXFKP 242 Escherichia coli
P9WMU3 143 ALLHRFGIAAp-aS-ADRSRAVVMSFSAAAVWRIRRAAP-----LLPTVLLGKTPRYLTSs-----------AATAVGAT 204 Mycobacterium tubercu...
P10908 132 AARELWAG-------MTPPLLS--SFEIDALEAAQQAAP-----ELPRGLLLD--EWRDDw-------R--ELTARLGCV 186 Escherichia coli K-12
O02322 196 LVSGFNPIDTylvKMADPKILTGFTWRSWELSTTDEAAT-----TPRFTGTLHAVASVLDv-------LAFGLARSLIIP 263 Caenorhabditis elegans
Q9UAW8 206 IVCSFFPWVVyriKKGDQKILTGLTWRLKFWSYHDIENIrp-rySGPKQMLFEMIDVAHVw------lLKKVTPWYLGAD 278 Caenorhabditis elegans
O14169 153 MLRVNSDLD------FWKDKVSFCLWSHRFIPACDRYAP-----SIPLYHIGFNFAYAERh---------FVMHPRVKGV 212 Schizosaccharomyces p...
Q08959 128 DLKFWQERITwglWLLDWYDFGIETGVLKDFKVIVISLS------LDIASQFVKRSLTLNd----------PHYKLFGIS 191 Saccharomyces cerevis...
1O1Z_A 127 KNLIFSSFD---------LDLLDEKFKGTKYGYLIDEEN------YGSIENFVERVEKERp-----------YSLHVPYQ 180 Thermotoga maritima
Q9RSP0 165 GATGRVIAAS----FSDAALNEFRRLCPEVMTSMTEREL------RPLVLLSKVGLSALAp----------TPGQVAQVP 224 Deinococcus radiodurans
O07244 132 LIGSFSERR-----RRRALRLL--TKRVASSAGTGALLA-----WLTARPLGS-RAYAWRm-------M--RDIDCVQLP 189 Mycobacterium tubercu...

1T8Q_C 243 GAXKQVAEYADGIgpdyhxlieetsqpgniklTGXVQDAQQNK-LVVHPYTVRSDklpeytpdvnqLYDaLYNKAGVNGL 321 Escherichia coli
P9WMU3 205 AVGPSLPALKEY--------------------PQLVDRSAAQG-RAVYCWNVDEY-----------EDIdFCREVGVAWI 252 Mycobacterium tubercu...
P10908 187 SIHLNHKLLNKA----------------------RVMQLKDAG-LRILVYTVNKP-----------QRAaELLRWGVDCI 232 Escherichia coli K-12
O02322 264 KFLGSDVIFYHVSd-----------------iSRFLKTDAAANnIYLAGWTSNNQ-----------YEQvWLRDYLKVPF 315 Caenorhabditis elegans
Q9UAW8 279 LLLTNNLDISQA----------------------LIMDQRRRG-MRVAVWTVNDM-----------AEMhWMLKTLNIPI 324 Caenorhabditis elegans
O14169 213 SMAVALFLLPHS--------------------QDFVDLVHAQG-KQVFAWTLNTP-----------SSIyLALIRGCDGL 260 Schizosaccharomyces p...
Q08959 192 VHFVSSWTSQFR---------------------LRLLPVLMKNdIKVYLWTVNKP-----------IDFkYLCELPIHGA 239 Saccharomyces cerevis...
1O1Z_A 181 AFELEYAVEVLR-------------------------SFRKKG-IVIFVWTLNDP------------EIyRKIRREIDGV 222 Thermotoga maritima
Q9RSP0 225 VRSGGIEIVTPA----------------------FVRALHARG-VAVQVWTIDDE-----------AEMrRLVQMGVDGV 270 Deinococcus radiodurans
O07244 190 SRLGGVPVITPA----------------------RVRGFHAAG-RQVHAWTVDEP-----------DVMhTLLDMDVDGI 235 Mycobacterium tubercu...

1T8Q_C 322 FTDFPDK 328 Escherichia coli
P9WMU3 253 GTHHPGR 259 Mycobacterium tuberculosis H37Rv
P10908 233 CTDAIDV 239 Escherichia coli K-12
O02322 316 LTDNVGT 322 Caenorhabditis elegans
Q9UAW8 325 LTDYPEL 331 Caenorhabditis elegans
O14169 261 LSDDPVM 267 Schizosaccharomyces pombe 972h-
Q08959 240 ITDDPIK 246 Saccharomyces cerevisiae S288C
1O1Z_A 223 ITDEVEL 229 Thermotoga maritima
Q9RSP0 271 ITNRPDL 277 Deinococcus radiodurans
O07244 236 ITDRADL 242 Mycobacterium tuberculosis
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