6DG8,1OED,1OED


Conserved Protein Domain Family
Neur_chan_memb

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pfam02932: Neur_chan_memb 
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Neurotransmitter-gated ion-channel transmembrane region
This family includes the four transmembrane helices that form the ion channel.
Statistics
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PSSM-Id: 397193
Aligned: 50 rows
Threshold Bit Score: 147.8
Threshold Setting Gi: 926698573
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6DG8_A       220 LLLPSIFLMVVDIVGFCLPPDS-GERVSFKITLLLGYSVFLIIVSDTLP-ATaIGTPLIGvYFVVCMALLVISLAETIFI 297 house mouse
P28476       268 TYFPATLMVMLSWVSFWIDRRAvPARVSLGITTVLTMTTIITGVNASMPrVS-YVKAVDI-YLWVSFVFVFLSVLEYAAV 345 human
P24046       288 TYFPATLMVMLSWVSFWIDRRAvPARVPLGITTVLTMSTIITGVNASMPrVS-YIKAVDI-YLWVSFVFVFLSVLEYAAV 365 human
P26714       256 TYLPSILIVMLSWVSFWINHEAtSARVALGITTVLTMTTISNGVRSSLPrIS-YVKAIDI-YLVMCFVFVFAALLEYAAV 333 great pond snail
P19019       250 TYMPSILITILSWVSFWINYDAsAARVALGITTVLTMTTINTHLRETLPkIP-YVKAIDM-YLMGCFVFVFLALLEYAFV 327 chicken
P24045       249 TYMPSILITILSWVSFWINYDAsAARVALGVTTVLTMTTINTHLRETLPkIP-YVKAIDV-YLMGCFVFVFLALLEYAFV 326 chicken
P08220       250 TYMPSTLITILSWVSFWINYDAsAARVALGITTVLTMTTISTHLRETLPkIP-YVKAIDI-YLMGCFVFVFLALLEYAFV 327 cattle
XP_004042905 255 MYIPSLLIVILSWISFWINMDAaPARVGLGITTVLTMTTQSSGSRASLPkVS-YVKAIDI-WMAVCLLFVFSALLEYAAV 332 western lowland...
P25123       274 IYIPSGLIVIISWVSFWLNRNAtPARVALGVTTVLTMTTLMSSTNAALPkIS-YVKSIDV-YLGTCFVMVFASLLEYATV 351 fruit fly
P22933       254 SYMPSVLLVAMSWVSFWISQAAvPARVSLGITTVLTMTTLMVSARSSLPrAS-AIKALDV-YFWICYVFVFAALVEYAFA 331 house mouse
6DG8_A       298 VRLVH--KQDLQRPVPDWLRHLVLDRIAWILCLGEQPMAHRPPA------------------------------------ 339 house mouse
P28476       346 NYL---------TTVQERKERKLREKFPCMCGM----------------------------------------------- 369 human
P24046       366 NYL---------TTVQERKEQKLREKLPCTSGLPPP-------------------------------------------- 392 human
P26714       334 NYTYWgaRAKRKAKRLRERATSVRKRVDDGDQMNNTNMDTVELKevhmvp------------------------------ 383 great pond snail
P19019       328 NYIFFg-KGPQRQKKLAEKSAKANNDRSRFEGSRVDTH------------------------------------------ 364 chicken
P24045       327 NYIFFg-RGPRQQKKQSERISKANNERHRYEEKRVReq------------------------------------------ 363 chicken
P08220       328 NYIFFg-KGP--QKKGAGKQDQSANEKNKLEMNKVQVDAH---------------------------------------- 364 cattle
XP_004042905 333 NFVSR-----QHKELLRFRRKRRHHKSPMLNLFQEDea------------------------------------------ 365 western lowland...
P25123       352 GYMAK--RIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPNAnvggpggvgvgpggpggpgggvnvgvgmgmgpehgh 429 fruit fly
P22933       332 HFNADy-RKKRKAKVKVTKPRAEMDVRNAIVLFSLsa------------------------------------------- 367 house mouse
6DG8_A       340 --------------------------TF-----------------QANKTDDCSGSDlLPAMGNHCSHVGGPQDLEKTPR 376 house mouse
P28476       370 ---------------------------------------------LHSKTMMLDGS--YSESEANSLAGYPRSHILTEEE 402 human
P24046       393 ---------------------------------------------RTAMLDGNYSDGeVNDLDNYMPENGEKPDRMMVQL 427 human
P26714       384 --------------------tsvgvtNS-----------------QSFNLDLDDGSGd--DTGFRVVPPIPRSFTHSHAT 424 great pond snail
P19019       365 ---------------------------------------------GNILLTSLEIHNeVASNEVTTSVTDARNSTISFDN 399 chicken
P24045       364 ------------------------vdPY-----------------GNILLSTLDMNNeLLATDMMSSVGDSRNSVMSFEG 402 chicken
P08220       365 ---------------------------------------------GNILLSTLEIRNeTSGSEVLTGVGDPKTTMYSYDS 399 cattle
XP_004042905 366 ------------------------geGR-----------------FNFSAYGMGPAClQAKDGISVKGANNSNTTNPPPA 404 western lowland...
P25123       430 ghghhahshghphapkqtvsnrpigfSNiqqnvgtrgcsivgplfQEVRFKVHDPKAhSKGGTLENTVNGGRGGPQSHGP 509 fruit fly
P22933       368 ------------------------agVS-----------------QELAISRRQGR--VPGNLMGSYRSVEVEAKKEGGS 404 house mouse
6DG8_A       377 --GRGSPLPp-----pREASLAVRGLLQELSSIR------HFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSI 443 house mouse
P28476       403 rqDKIVVH--------LGLSGEANAARK------------KGLLKGQTGFRIFQN----THAIDKYSRLIFPASYIFFNL 458 human
P24046       428 tlAS------------ERSSP-------------------QRKSQRSSYVSMRID----THAIDKYSRIIFPAAYILFNL 472 human
P26714       425 thGYIPTNVvrr-rssSHVPPRRRRLL-------------SHFRQKAKSIKVKIPRVQDVNTIDKYARLMFPLLFIIFNT 490 great pond snail
P19019       400 sgIQYRKQSs-----hRESLGRRSSDRTGSHSKR------GHLRRRSSQLKIKIPDLTDVNAIDRWSRMVFPFTFSLFNL 468 chicken
P24045       403 sgIQFRKPLasr--dgFGHHPTLDRHVPLTHHAAarnranCRLRRRSSKLKLKIPDLTDVSTIDKWSRIIFPITFGFFNL 480 chicken
P08220       400 asIQYRKPMss----rEGYGRALDRHGAHSK---------GRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNV 466 cattle
XP_004042905 405 ----------------PSKSP----------------------------EEMRKLFIQRAKKIDKISRIGFPMAFLIFNM 440 western lowland...
P25123       510 gpGQGGGPPgggggggGGGGPPEGGGDPEAAVPA------HLLHPGKVKKDINKLLGITPSDIDKYSRIVFPVCFVCFNL 583 fruit fly
P22933       405 ----------------RPGGP-------------------GGIRSRLKPIDADT--------IDIYARAVFPAAFAAVNI 441 house mouse
6DG8_A       444 TLV 446 house mouse
P28476       459 IYW 461 human
P24046       473 IYW 475 human
P26714       491 SYW 493 great pond snail
P19019       469 IYW 471 chicken
P24045       481 VYW 483 chicken
P08220       467 VYW 469 cattle
XP_004042905 441 FYW 443 western lowland gorilla
P25123       584 MYW 586 fruit fly
P22933       442 IYW 444 house mouse
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