6ALE,5WBX,6CNM


Conserved Protein Domain Family
CaMBD

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pfam02888: CaMBD 
Calmodulin binding domain
Small-conductance Ca2+-activated K+ channels (SK channels) are independent of voltage and gated solely by intracellular Ca2+. These membrane channels are heteromeric complexes that comprise pore-forming alpha-subunits and the Ca2+-binding protein calmodulin (CaM). CaM binds to the SK channel through this the CaM-binding domain (CaMBD), which is located in an intracellular region of the alpha-subunit immediately carboxy-terminal to the pore. Channel opening is triggered when Ca2+ binds the EF hands in the N-lobe of CaM. The structure of this domain complexed with CaM is known. This domain forms an elongated dimer with a CaM molecule bound at each end; each CaM wraps around three alpha-helices, two from one CaMBD subunit and one from the other.
Statistics
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PSSM-Id: 397156
Aligned: 26 rows
Threshold Bit Score: 60.7576
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6ALE_B        19 DTQLTKRVKNAAANVLRETW-LIYKNTKL---VKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDqantlvDLAK 91 
XP_011418649 337 DVNLDKRLKNEAANVMKSGW-FIYKFRKL-----KANSSMALSYQTKLLEAIYNIRQIKAAQRRLVDasitmtEVNK 407 Pacific oyster
EKC41352     377 qIKLDKLHRHAAADVVKQAM-MVWKLRRT---GLSFHCPRVLKHRRKLLDAIRRMKKSQFSKSQMRDsvigvvEISK 449 Pacific oyster
XP_008111977 239 DIQCAKEMKCSAANVLQEAW-LLYKHT------KRKDGRRARKHHRRLLAAIHMFRHVRMKHRKIRDrvntmvDISK 308 green anole
XP_016791575 304 DIQYTKEMKESAARVLQEAW-MFYKHT------RRKESHAARRHQRKLLAAINAFRQVRLKHRKLREqvnsmvDISK 373 chimpanzee
XP_007654812 252 DIQCAKEMKESAARVLQEAW-HFFKHG------RRKEQGASRTHQRRLLAAIHEFRQVRLKHRKLRDqvnslvDISK 321 platypus
4_pfamImport   1 -TKLSKRVRHAAANVVRECW-LLHRTT------PKGNPAEHRRHQRCLLDAIAVFHHLRFKEKMLSDyisemaDLSK 69 
Q11122       559 DSKLAREHKEAAARVLQHTW-HIHKCLQ----GSDGGNRRLRTYQRKFLKAIHKFRSVKSEMREFSEnn--sqNNPQ 628 Caenorhabditis ele...
NP_001256595 308 ENNITNEHKNAAACVLQNTWrTVLRARDYqksSSRRNQQRLAKMQRMLLCSVITFRKTRWKLRMQMEdeddffTARR 384 Caenorhabditis ele...
6CNM_A       304 DIQYTKEMKESAARVLQEAW-MFYKHTR------RKESHAARRHQRKLLAAINAFRQVRLKHRKLREqvnsmvDISK 373
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