3MNM,5CN1,2DWX


Conserved Protein Domain Family
Alpha_adaptinC2

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pfam02883: Alpha_adaptinC2 
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Adaptin C-terminal domain
Alpha adaptin is a heterotetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This ig-fold domain is found in alpha, beta and gamma adaptins.
Statistics
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PSSM-Id: 397151
Aligned: 97 rows
Threshold Bit Score: 44.2371
Threshold Setting Gi: 124447723
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3MNM_A     9 ARTLVNQSPNLKIEFEISReSNSVIRIXSFFTNLS-SSPISNLVFLLAVPKSMSLXLQPQSSNFMI-GnaKDGISQEGTI 86   baker's yeast
EDW28585 713 NNGVLFENEMLQIGVKSEF-RQNLGRLGLFYGNKT-QVPLSNFNPVLQWSAEETLKLNVQMKAVEPtLeaGAQIQQLLTA 790  Drosophila persimilis
P17426   751 NSGVLFENQLLQIGVKSEF-RQNLGRMYLFYGNKT-SVQFQNFLPTVVHPGDLQTQLAVQTKRVAAqVdgGAQVQQVLNI 828  house mouse
Q0IHS1   730 NNGVLFENQLLQIGVKSEF-RQNLGRMYLFYGNKT-SVQFQSFTPTVNYPGELQSQVNIQTKPVDPvVegGAQVQQVLNI 807  tropical clawed frog
Q4SW01   730 NNGVIFENQLLQIGLKSEY-RQNLGRIYIFYGNKT-STQFLSFSSNVNIL-NYSSQLIVHAKTVDPiIegGAQVQQILNI 806  spotted green puff...
Q5BJ37   713 NNGVLFENQLLQIGVKSEF-RQNLGRMFIFFGNKM-SSQFQNFTSTVICSDELSASLNVQSKPAEDtVdgGAQVQQVVNV 790  African clawed frog
Q5F3T4   712 NNGVLFENQLLQIGLKSEF-RQNLGRMFIFYGNKT-STQFLNFTPTVICSDDLQPSLNLQTKPVDPtVdgGAQVQQVVNI 789  chicken
CAP34239 694 SNAILWEDDYIQVGCKLET-RNNLGRLGMFYGNKT-SQPFNKFTPIITCPGALAVQLQAQAKPVEPlVaaGTQVQQLINF 771  Caenorhabditis bri...
Q1EQ20   664 NEGIIFQDQNIQIGYRSKV-IDNVVGIQLFYGNIS-PFPIT-VNIHIIVPDGLTSSLQQDNLTIES----HQQINHIIQF 736  Entamoeba histolytica
Q22E31   711 SIGQVYESNELTVQFKSDY-QQHMGKIAMQFESKIgRMENVSFVIANSDQNGLDFNISPIKYDEHP-----QIMMQVMST 784  Tetrahymena thermo...
3MNM_A    87 enapaNPSKALXVKWKVNYS-VNSTQAEETA--VFTLP 121  baker's yeast
EDW28585 791 e---cIEDYADAPTIEISFR-YNG--TQQKF--SIKLP 820  Drosophila persimilis
P17426   829 e---cLRDFLTPPLLSVRFR-YGG--TAQSL--TLKLP 858  house mouse
Q0IHS1   808 e---cLSDFDEAPLINIKFR-YGGTLQNI----TLKLP 837  tropical clawed frog
Q4SW01   807 e---cVSDFMEAPVLNIQFR-YGGALQNI----AVKLP 836  spotted green pufferfish
Q5BJ37   791 e---cVQEFTDHPLLNIQFR-YGGAFQNVSV----KLP 820  African clawed frog
Q5F3T4   790 e---cVSDFMEAPILNIQFR-YGGTFQNLSV----KLP 819  chicken
CAP34239 772 vcvqeF-QKMPIMNIKFTFTdRAGAIQNFDK--NFYLP 806  Caenorhabditis briggsae
Q1EQ20   737 k---lNATFLEPPQLQLDYH-----FNSTSAsvSLPLP 766  Entamoeba histolytica
Q22E31   785 ---------DPRQQMPIGLLaYDVNGQNKRI--EIPLP 811  Tetrahymena thermophila SB210
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