3C49


Conserved Protein Domain Family
PARP_reg

?
pfam02877: PARP_reg 
Poly(ADP-ribose) polymerase, regulatory domain
Poly(ADP-ribose) polymerase catalyzes the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active.
Statistics
?
PSSM-Id: 397145
Aligned: 165 rows
Threshold Bit Score: 76.017
Threshold Setting Gi: 765552194
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3C49_A          8 CSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDgg--------------- 72  
XP_003285536  104 SKLPKEIFDVMSQFCNVEAISNQLKSLKIDTDIMPLGRLSKDAINNAVAILGKNDDTLPPINEvl--------------- 168  Dictyostelium...
EFJ30299      616 SNLHPRVVSLMKMLFDIETYKSAMLEFEINPNEMPLGKLTKAHIAKGFDVLTRIQNVLKREQQdpr-------------- 681  Selaginella m...
XP_002960621  343 CKLDPKVARFCKCLFSQAVYRHAMFEMGINSPELPLGSLSEFHFKRCEECLLEFADFLQKESDskk-------------- 408  Selaginella m...
CBI28338      466 CKLEPLVANFMKVLCSQEIYRYAMMEMGLDSPDLPMGMLSNIHLKRCEEVLLNFIETVKSIKEmdik------------- 532  wine grape
Q9FK91        450 CKLDSFVANFIKVLCGQEIYNYALMELGLDPPDLPMGMLTDIHLKRCEEVLLEFVEKVKTTKEtgqk------------- 516  thale cress
EEF38513      452 SKLEPQLAYFMKILCSQEIYRYALMEMGLDPPELPMGMLSDLHLKRCEEVLLQFVEAVKSMKGtgqk------------- 518  castor bean
XP_018687013  454 CKLEPLVAKFMKVLCSQEIYRYAMMEMGYDCPDLPMGMVTDLHLERCEEELLNFREDIKKAPDssdk------------- 520  wild Malaysia...
XP_010652358  647 SQLAPQVVELMKMLFNVETYRSAMMEFEINMSEMPLGKLSKSNIQKGFEALTEIQNLLNSNAHdpsf------------- 713  wine grape
Q54E42       2145 SQLPKELYDVMAQFCNVESISHQLKNLKIDTDIMPLGRISKDLIQKAITVLGKLSEAVEQIRLieeheankrassftnat 2224 Dictyostelium...
3C49_A         73 --------------------------------qSLEELSSHFYTVIPHnfgHSQ-P---PPINSPELLQ-AKKDMLLVLA 115 
XP_003285536  169 --------------------------------eSQLELSNKFFELIPH---SDFrTekmQVLRHQHEIA-TKIKLLQNLD 212  Dictyostelium...
EFJ30299      682 ------------------------------rqvELIDGSNQFNTLIPSt-----hP---TLIDDEDVLK-TKIQMLEALR 722  Selaginella m...
XP_002960621  409 ------------------------------heqMCLDFSNKWFSLVPS-----ThP---TVISDIAHLTeLGASVLESLK 450  Selaginella m...
CBI28338      533 ------------------------------akaTWSDFSQRWFTLLHS-----TrP---FIFRDHQEIAdHAAAALEIVR 574  wine grape
Q9FK91        517 ------------------------------aeaMWADFSSRWFSLMHS-----TrP---MRLHDVNELAdHAASAFETVR 558  thale cress
EEF38513      519 ------------------------------aeaVWSDYSQRWFTLMHS-----TrP---LILRDYDELAdNVAAAFETVR 560  castor bean
XP_018687013  521 ------------------------------anvLWLDFTNKWFTFMHS-----VrP---FIMKNFQELAdHVAAGLECIR 562  wild Malaysia...
XP_010652358  714 ------------------------------kesLIVDASNRFFTVIPSi-----hP---HVIRDEDDFK-SKVKMLEALQ 754  wine grape
Q54E42       2225 tvgsgvsgsggdststtdkpeepnfpplndvkeSLIKLSNEFYELIPH---SNFsTermVILKSAKEIT-AKTTLLQNLD 2300 Dictyostelium...
3C49_A        116 DIELAQALQAVSEQEKTVeevpHPLDRDY 144 
XP_003285536  213 EMETVSKILIAAHQNSSM----HPYDYCF 237  Dictyostelium purpureum
EFJ30299      723 DIEIASQLIKSADEDDES----DPLDVHY 747  Selaginella moellendorffii
XP_002960621  451 AISVASHIIGDMTGDTLD----DPLSDRY 475  Selaginella moellendorffii
CBI28338      575 DITVASHLVGDLTGSTLD----DPLFDRY 599  wine grape
Q9FK91        559 DINTASRLIGDMRGDTLD----DPLSDRY 583  thale cress
EEF38513      561 DINVASRLIGDMSGSTLD----DPLSDRY 585  castor bean
XP_018687013  563 DINVASRLVGDMSGATVD----DPLSDRY 587  wild Malaysian banana
XP_010652358  755 DIEIASRLVGFDVDSD------DSLDDKY 777  wine grape
Q54E42       2301 ELETVSKILIAAHQNTTM----HPYDYCF 2325 Dictyostelium discoideum AX4
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap