4C12,2WTZ,2GCA,1GQY,2Y68,1GG4,1E8C


Conserved Protein Domain Family
Mur_ligase_C

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pfam02875: Mur_ligase_C 
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Mur ligase family, glutamate ligase domain
This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl, and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Statistics
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PSSM-Id: 397143
Aligned: 49 rows
Threshold Bit Score: 41.5598
Threshold Setting Gi: 74578960
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4C12_A 332 VEGRLEVLDPsLPIDLIID-YAHTADGMNKLIDAVqpfvkQKLIFLVGmagERDLTKTPEMGRVACR-ADY-VIFtpdnp 408 Staphylococcus aureus
P57995 318 GRHRAEVVAVaDGIRYVDDsKATNPHAALVSVLAY-----PRVVWVAGg-lLKGASVDAEVARMAPQlVGA-VLI----- 385 Mycobacterium leprae TN
P73668 310 VPHRLEPICTiNGVQFINDsKATNYDAAEVGLSSMk----GPTILIAGg-eAKEGDDQAWLAQIRQKaVAV-LLI----- 378 Synechocystis sp. PCC...
O67852 273 LPHRLEFLGNfNGVEVYNDsKSTTPHALMHALKTFp---dNSVILIVGg-kDKGADFYSLRHIVQKKvKIA-LAI----- 342 Aquifex aeolicus VF5
2Y68_A 300 LPHRFEVVLEhNGVRWINDsKATNVGSTEAALNGLhv--dGTLHLLLGg-dGKSADFSPLARYLNGD-NVRlYCF----- 370 Escherichia coli K-12
O07108 312 VPHRTQFVGEvQQRRFYNDsKATNILATEMALSGFd---nQKLLLLAGg-lDRGNSFDELVPALLGl-KAI-VLF----- 380 Enterococcus faecalis...
O07669 317 VPHRTQYVGEfQGRKFYNDsKATNILATKMALSGFq---lDQLVLIAGg-lDRGNSFDELIPALKGi-KAL-ITF----- 385 Enterococcus hirae
P0C0D7 310 VKHRLQRVGQiKDITFYNDsKSTNILATQKALSGFd---nSRLILIAGg-lDRGNEFDDLVPDLLGl-KQM-IIL----- 378 Streptococcus pyogenes
Q2FZ92 308 IEHRLQYVGTnRTNKYYNDsKATNTLATQFALNSFn----QPIIWLCGg-lDRGNEFDELIPYMENv-RAM-VVF----- 375 Staphylococcus aureus...
Q03522 312 VKHRLQYVTTvNGRKFYNDsKATNILATSKALSAFd----KPVILLAGg-lDRGNGFDDLKPYMKHv-KAV-LTF----- 379 Bacillus subtilis sub...
4C12_A 409 anDDPKMLT 417 Staphylococcus aureus
P57995 386 --GRDRAMV 392 Mycobacterium leprae TN
P73668 379 --GDAAPNF 385 Synechocystis sp. PCC 6803 substr. Kazusa
O67852 343 --GETKEKI 349 Aquifex aeolicus VF5
2Y68_A 371 --GRDGAQL 377 Escherichia coli K-12
O07108 381 --GETKEKL 387 Enterococcus faecalis V583
O07669 386 --GETQNRL 392 Enterococcus hirae
P0C0D7 379 --GESAERM 385 Streptococcus pyogenes
Q2FZ92 376 --GQTKAKF 382 Staphylococcus aureus subsp. aureus NCTC 8325
Q03522 380 --GQTAPKL 386 Bacillus subtilis subsp. subtilis str. 168
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