Conserved Protein Domain Family
DDHD

?
pfam02862: DDHD 
DDHD domain
The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family.
Statistics
?
PSSM-Id: 397132
Aligned: 151 rows
Threshold Bit Score: 85.196
Threshold Setting Gi: 384485021
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q8IAY0        225 KIHYLFMLGSPL-------------SALLSLYkpeyindGLKlnnGL--------------------------------- 258  Plasmodium fa...
Q6C3H4        680 NTSNLFLVGSPV-------------GFFMLLH-------NANfkaRSeengpqy-----------------------gcl 716  Yarrowia lipo...
XP_003329167  617 DTSKVFLVGSPV-------------AFFFHLH-------RAQliaREgvssstrldsknsaewrkanrvstdevgqygcl 676  Puccinia gram...
XP_007411848  624 GTETVFLVGSPLvigwlmslklqqvAFFFHLH-------RAQliaRLpsnkasdpssewkrkk----riatdevgrygcl 692  Melampsora la...
GAC94672      786 NTHSFFAVGAPV-------------ALFFVLH-------RAQliaRSglvrssrfvrdepgv-------tldaegrfgcl 838  Pseudozyma hu...
KIS66873      779 NTHSFFAVGAPV-------------ALFFVLH-------RAQliaRSgvvrssrfvrdepgi-------tlngegrfgcl 831  Ustilago mayd...
CBQ69580      798 NTHSFFAVGAPV-------------ALFFVLH-------RAQliaRSglvrssrfvkdepgv-------tlasegkygcl 850  Sporisorium r...
XP_011388591  667 NVKNLFLIGSPV-------------AFFFHLN-------GGQliaRSgtqrhpnndsdav----------dgdtgrygcl 716  Ustilago mayd...
XP_016290775  538 NVKNLFFIGSPV-------------AFFFHLD-------GGQliaRSgtdrhpdnhgdal----------dgekgrygcl 587  Kalmanozyma b...
KDE07713      486 DTRLFILVGSPL-------------AFFLHLG-------QGQliaRRgrartqnvgrdia----------ldragrygcm 535  Microbotryum ...
Q8IAY0        259 ---KFYNIFHGFDPVAFRIEPLIYPGI-KNIp-----------EPVLINYWRNnGARYw--------------------- 302  Plasmodium fa...
Q6C3H4        717 avkNLYNVINFSDPIAYLLNPTVDTDLaENI------------ETANVPTEKNfPLEGedeswik----------fpvkf 774  Yarrowia lipo...
XP_003329167  677 aaeTIYSVYISTDPVAYSMNACVDCGHsKRI------------KPIDAHSFTKkF------------------------- 719  Puccinia gram...
XP_007411848  693 aaeNVYNVYISTDPVSYCMNACVDSKFvNKFctmstmiyakqiRPIDVTSMTQnILT----------------------- 749  Melampsora la...
GAC94672      839 avtSFYNIWNQYDPVATRASPCVDVQYaKMV------------KPVPLNKAIRsILRAdpeadnhdiaedggsqsfgsgn 906  Pseudozyma hu...
KIS66873      832 avtSFYNIWNQYDPVATRASPCVDVQYaKQL------------KPVPLNKAIRsILRAdpeaenhdiaedggtwsfgsgn 899  Ustilago mayd...
CBQ69580      851 aitNFYNIWNQYDPVATRASPCVDVQYaKLL------------KPVPLNKVIRsILRAdpdaenldiaedggsqsfgshn 918  Sporisorium r...
XP_011388591  717 aaeNVYNIFNPNDPVAFKLAPTVDSAYaKLI------------KPVAIESAAEaVLRTl--------------------- 763  Ustilago mayd...
XP_016290775  588 ateNVYNIFNPNDPVAFQLAPTVDSAYaKLI------------KPISIESATEvILRSl--------------------- 634  Kalmanozyma b...
KDE07713      536 aidAVYNVYHETDPVAFALNATVDREYaKLI------------KPIAIPSTNStLFENl--------------------- 582  Microbotryum ...
Q8IAY0        303 -FEWDKNMQNAKLAIVQNLNDFTSAITNGf-----------------------------------------yKFlgknen 340  Plasmodium fa...
Q6C3H4        775 pFWSPSGTPSVEEKESDKGVKAVKDL------------------------------------------------------ 800  Yarrowia lipo...
XP_003329167  720 ----------LETMRRKRPIAEPEST------------------------------------------------------ 735  Puccinia gram...
XP_007411848  750 ---LFESRASINEKRGIKHIGSLASISSIilkrsswfrsp---------------------kpdckpdtpaiEEl----- 800  Melampsora la...
GAC94672      907 aFDSNSGTAKRRAA--KRTKGFFGSWSRRagaaaavrkpqaadk--------------gdgeqtgdesacrsSMe----- 965  Pseudozyma hu...
KIS66873      900 aADPDARVAKRKAAAVKRTKGFFGTWSRRteaataprktqavee-------------ddgekigdddsalrsSMd----- 961  Ustilago mayd...
CBQ69580      919 aPDSDAGTAKRKAAAAKRNKGFFGSWSRKageatraarpktkaag------------egdgeqtgdegvprsSMd----- 981  Sporisorium r...
XP_011388591  764 -SLPRMSVTQVFEKYKDHPFQGVGKIIRQarilekddtalpcdlspdeqrhvsrrekgkciveasdyiqtvrKWq----- 837  Ustilago mayd...
XP_016290775  635 -SLPRISVSRVFEKYKDRPFQGVGKIVRQarilenkqdalpsdlseleekhlkqrklgkrivdasdyiqtvrKWh----- 708  Kalmanozyma b...
KDE07713      583 -SDTYSRISNVLDISRFWSSP----------------------------------------------------------- 602  Microbotryum ...
Q8IAY0        341 ndedqstlnknicynkceskdinifllkVKENQRKIALQKKKIHRYNKKNNITykenvaekknahyNSIHNINDNNicdn 420  Plasmodium fa...
Q6C3H4        801 ----------------------------SEGSKDATDTKDLEEFSASEVKGSLkprprsdstksdkSMSSRLSGIFssrp 852  Yarrowia lipo...
XP_003329167  736 ----------------------------LTRNVSLSSLSSLVASSWMGSTKKRepddlintnngnpQATLIGDVIRpscs 787  Puccinia gram...
XP_007411848  801 ----------------------------LIETNGAEDAESTQEQQADRKRPISrtsnkqnssvsetINVK---------- 842  Melampsora la...
GAC94672      966 ----------------------------VSEADEAKDARPDVQGLRSKLAEKAreeekrkeerermADEERK-------- 1009 Pseudozyma hu...
KIS66873      962 ----------------------------VSETEEAREARTEAESLRSKFAAKAreeedrkeerkriADEERK-------- 1005 Ustilago mayd...
CBQ69580      982 ----------------------------VSETDEVREAREDAEGLRSKLAAKArqeekrkeereriADEERK-------- 1025 Sporisorium r...
XP_011388591  838 ----------------------------HLRDASATACDLGAAGS-AREMETErasrltrrtrsttLIWDRSSA------ 882  Ustilago mayd...
XP_016290775  709 ----------------------------KLQNADPGSADAGAATPEKRELETEegrrkkmlqpetaLRTSSIPGEE---- 756  Kalmanozyma b...
KDE07713      603 ----------------------------EKNEALEGSKNEGPPGSNSGTEAYSaekvgrgqsssnlAAKPKMPARRpt-- 652  Microbotryum ...
Q8IAY0        421 icdnicenicdnicdnirdnirdnmrdnirdnicdhhlndisyndedsqdtYFGHEKYKRKYDhndeqkkegtyyskeen 500  Plasmodium fa...
Q6C3H4        853 ksplspnarktehkks---------------pmatsgpfspqevspkdevpIFTPTPVKPMNAsveiggsligegn---- 913  Yarrowia lipo...
XP_003329167  788 plppsdpp--------------------------------prpprptsminIGWSDLVRKRTRvftassste-------- 827  Puccinia gram...
XP_007411848  843 ---------------------------------------------------KRRDDV----------------------- 848  Melampsora la...
GAC94672     1010 ---------------------------------------------------KGMSDKR---------------------- 1016 Pseudozyma hu...
KIS66873     1006 ---------------------------------------------------KGISAKR---------------------- 1012 Ustilago mayd...
CBQ69580     1026 ---------------------------------------------------KGMSAKR---------------------- 1032 Sporisorium r...
XP_011388591  883 ---------------------------------------------------RN--------------------------- 884  Ustilago mayd...
XP_016290775  757 ---------------------------------------------------ADDKHDFDL-------------------- 765  Kalmanozyma b...
KDE07713      653 -------------------------------------------------nkRMPSEMPMGKR------------------ 665  Microbotryum ...
Q8IAY0        501 ssyidstksicasqdsnseysffdhelsdnsnnlyeenrrnYDDHNKKRESICNSNNINDALniRYDYQLQ-EFIMEHy- 578  Plasmodium fa...
Q6C3H4        914 -----------------------------ltssppksiplqKRDFAREHQAEQQMQGLNDNG--QIDWIVPlTGALEN-- 960  Yarrowia lipo...
XP_003329167  828 ---------------------------------nirdehlkKSKHGEDTLGRMRFLGLNPTG--SVDFVIPsLGl----- 867  Puccinia gram...
XP_007411848  849 ------------------------------------------------SDAQLRFEALNPTG--CVDFVIPsLGm----- 873  Melampsora la...
GAC94672     1017 -----------------------------------------------KARAEARLRALNPLH--RIDFCMPvEG-YSLls 1046 Pseudozyma hu...
KIS66873     1013 -----------------------------------------------QARAEARLRALNPLH--RIDFYMPvEG-YSLls 1042 Ustilago mayd...
CBQ69580     1033 -----------------------------------------------KARAEARLRALNPLH--RIDYYMPvEG-YSLls 1062 Sporisorium r...
XP_011388591  885 ---------------------------------------------------VVS-APLNPHG--CIDYHLSeSISl---- 906  Ustilago mayd...
XP_016290775  766 ---------------------------------------------DSLERAERRFRALNPHG--CIDYHLSaSISl---- 794  Kalmanozyma b...
KDE07713      666 -------------------------------------------EFESVSRAEQRFKALNPQG--CIDFYMPaEGi----- 695  Microbotryum ...
Q8IAY0        579 --iYPLAVAKSHFNYFIIKDISFFILKELI 606  Plasmodium falciparum 3D7
Q6C3H4        961 ---QYVSMITAHSNYWDNKDLARMCAIESC 987  Yarrowia lipolytica
XP_003329167  868 --nQYVDMVTAHAAYWTDNRFARLVLIglf 895  Puccinia graminis f. sp. tritici CRL 75-36-700-3
XP_007411848  874 --nQYLDMVTAHAAYWSEPRFAKFVLTQLL 901  Melampsora larici-populina 98AG31
GAC94672     1047 tinQYTELMTAHMSYWAKVDFADFLITQLM 1076 Pseudozyma hubeiensis SY62
KIS66873     1043 sinQYAELMTAHMSYWTKVDFADFLITQLM 1072 Ustilago maydis 521
CBQ69580     1063 tinQYAELMTAHMSYWTKVDFADFVITQLM 1092 Sporisorium reilianum SRZ2
XP_011388591  907 --sAYLDALGAHLCYWTHRDFAVFVLTQLF 934  Ustilago maydis 521
XP_016290775  795 --sGYLDMFGAHLSYWGHRDFAVFILTQLF 822  Kalmanozyma brasiliensis GHG001
KDE07713      696 --nQYIDALSSHASYWSSDSVATFVLTQLF 723  Microbotryum lychnidis-dioicae p1A1 Lamole
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap