2IP4,2YW2,3LP8,2XCL


Conserved Protein Domain Family
GARS_N
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pfam02844: GARS_N 
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Phosphoribosylglycinamide synthetase, N domain
Phosphoribosylglycinamide synthetase catalyzes the second step in the de novo biosynthesis of purine. The reaction catalyzed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the N-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase (see pfam00289). This domain is structurally related to the PreATP-grasp domain.
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Statistics
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PSSM-Id: 397126
Aligned: 917 rows
Threshold Bit Score: 66.2204
Threshold Setting Gi: 159894012
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2IP4_A         2 KVLVVGSG-GREHALLWKAAQS-PRVKRLYAAP--GNAGXealaelv--pwngdvEA------L--AD-WALAEG-IDLT 65  Thermus thermop...
Q6L0G7         2 KIMLVGSG-GREDSIARNIALN--H--ELYSVLtnENPSIiknskkyifydkkrhDL------I--AD-FALKNN-IDIA 66  Picrophilus tor...
EQB71304       4 KILLVGGG-GREDAVARRIVES-GS--QLFSALknRNPSIislstdtlitdeldhSA------I--LE-FALRKG-VDLA 69  Thermoplasmatal...
CDE24334       6 KILLYGQGnGRDHINHIELMKS-KGIE-VISLIknENALMeq------------yeNvkkikdLkeAViFAKEYK-PDLV 70  Clostridium sp....
WP_013607818   2 RILIIGGG-GREHALAKALKRSkQAIE-LFAIG--RNAGMqalct-------maplAlsdppaL--VD-YARTKA-IDLV 66  Sphaerochaeta g...
CCB80550       4 KILIIGGG-AREYALGRKFRED-ARIGDIYFSP--GNGGTqsigenv---------alenheeV--VR-FATDKH-IDLV 66  Helicobacter bi...
Q7VIK6         4 RILIIGNG-GREYAIGRVLKEE-SRVEALFFAP--GNGAThllgtnl---------tythpqeL--LE-SIKLHH-ITLV 66  Helicobacter he...
BAM31588       4 NILIIGNG-GREYAMGLVLKDD-KRVECLYFAP--GNGGThalgvni---------patkhtdI--LE-SIQKYN-ITLV 66  Helicobacter ci...
WP_013023079   4 KLLILGHG-GREYAMGLHLLRD-KNIDSLFFAP--KNAATerlgktf---------dfashqeL--IE--KIQEFgIDFV 66  Helicobacter mu...
WP_006656822   2 EIVIVGSG-GREYSIGLALQRE-CRIDGIYFYP--GNGATsklgkni---------nfkddneF--ID-FAITQK-IGLV 64  Helicobacter ca...

2IP4_A        66 LVGPEAPLVEGIADAF--QarGLLLFGPTQKAAXIE 99  Thermus thermophilus HB8
Q6L0G7        67 FVSPDGILANGLADDLikN--KIKTASPVKSAAMIE 100 Picrophilus torridus
EQB71304      70 FIGPDPVLDTPLTDTLisR--GIRVASPTRLAARIE 103 Thermoplasmatales archaeon A-plasma
CDE24334      71 MISNRADLAEGATEVFqkA--GFKVFGISKKAAHLE 104 Clostridium sp. CAG:440
WP_013607818  67 VIGPDEPLVCGLADVFraC--HIPCFGPSKEAARLE 100 Sphaerochaeta globosa
CCB80550      67 VIGPQEPLIEGLSDALalA--EIKVFGPSQKVSILE 100 Helicobacter bizzozeronii CIII-1
Q7VIK6        67 IIGPEAPLSEGLSDYLrsH--NVRVFGPSKAAARLE 100 Helicobacter hepaticus
BAM31588      67 IIGPEAPLSEGLSDFLiaH--NVRVFGPSLAASRLE 100 Helicobacter cinaedi CCUG 18818 = ATCC BAA-847
WP_013023079  67 IIGPEAYIIDGLSNALkmA--GIKVFGPSKEAGMLE 100 Helicobacter mustelae
WP_006656822  65 IIGPEAPLVEGLADKLreN--GILTFGPSQAAARLE 98  Helicobacter canadensis
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