3LP8,3MJF,1GSO,2YW2,2YS6,2XCL,2IP4,1VKZ


Conserved Protein Domain Family
GARS_C

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pfam02843: GARS_C 
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Phosphoribosylglycinamide synthetase, C domain
Phosphoribosylglycinamide synthetase catalyzes the second step in the de novo biosynthesis of purine. The reaction catalyzed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the C-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase (see pfam02787).
Statistics
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PSSM-Id: 397125
Aligned: 1023 rows
Threshold Bit Score: 42.846
Threshold Setting Gi: 524723301
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3LP8_A        349 ALCVVVASRGYPGEYK-K-NSIIngIENieklPNVQ----LLHAGtrregnnW--------VSDSGRVINVVAQGENLAS 414 Ehrlichia chaf...
CCC82578      348 TVVKAIAPLGYPVDRAmArGRRF--TIDw--dIVQRegcyVFFGS-------Aveds-agyVTLGSRAVEVLAAGRTPSE 415 Thermoproteus ...
Q8ZZK4        344 TVVKAVAPVGYPLDKKtAaGRRF--DVDw--vLVERegchVFFGS-------AapserggyETLGSRALEILAPGSTPEE 412 Pyrobaculum ae...
WP_012185723  351 TVAKAIAPLGYPHRRDlAaGRRI--SIDf--nGIKKlgcgLYFGS-------Veyvn-geyRTLGSRAVEILATGSSYSE 418 Caldivirga maq...
jgi:Vdis_0579 352 AISKAVAPLGYPHNRDlArGRSI--TIDm--gEIGRlgceVYFGS-------Vteeg-gtyRTLGSRAVEVLAVGNTYEE 419 Vulcanisaeta d...
BAK54604      347 SVVRAIAPLGYPLNKTmAsNHII--NIDv--qKIRElgckIYFGS-------Vsleg-mqlVTKGSRALELVVIND-FKE 413 Sulfurisphaera...
AAK40943      353 sIVRAVATLGYPISKQmAsGHKI--VVDl--eKMKErgcvVFFGS-------Valeg-mqlITKGSRALEIVAIGD-FEE 419 Saccharolobus ...
WP_012021910  347 TVVRAIAPLGYPLRREmAtGKEI--FLDv--nSMREkgclVYFGS-------Vsyeg-gklITRGSRALELVAFGD-FEE 413 Metallosphaera...
WP_013775912  346 SVVRAIAPYGYPLNKSlAkGQKF--HIDl--qKIKEkgciLYFGS-------Ialeg-nelIAQGSRALELVAFGD-FDE 412 Acidianus hosp...
Q4J8F4        348 SIVKAVAPLGYPLDKNmAtGHTI--WLDl--pRMREigcnVYFGS-------Isqeg-gklITKGSRALEITVVDD-YDK 414 Sulfolobus aci...
3LP8_A        415 AKHQAYAALD--L-LDWpDGIYRYDIGSC 440 Ehrlichia chaffeensis str. Arkansas
CCC82578      416 AYERAERCATavRgDG---LFYRRDIGSA 441 Thermoproteus tenax Kra 1
Q8ZZK4        413 AYQKAERCAAavKgDG---LYHRKDIGSP 438 Pyrobaculum aerophilum
WP_012185723  419 AHAKAEECISlvKsSDW-KLIHRVDVGEP 446 Caldivirga maquilingensis
jgi:Vdis_0579 420 THERVENCIAniKsPDW-QLIHRRDIGSR 447 Vulcanisaeta distributa DSM 14429
BAK54604      414 ASDKLDKCINyiSsDT--KLIFRHDIGRt 440 Sulfurisphaera tokodaii str. 7
AAK40943      420 AAENLDRCMQyiSsDT--KLIYRTDIGRT 446 Saccharolobus solfataricus P2
WP_012021910  414 ASRKLDTCTKmiSaNT--ELVYRTDIGRt 440 Metallosphaera sedula
WP_013775912  413 ASKKLDECMAyiSsDR--KIIYRSDIGRT 439 Acidianus hospitalis
Q4J8F4        415 AVEKLDRCFSliSsDT--KLIFRHDIGRT 441 Sulfolobus acidocaldarius
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